scholarly journals Strategies for Preventing Endoscopic Recurrence of Crohn’s Disease 1 Year after Surgery: A Network Meta-Analysis

2017 ◽  
Vol 2017 ◽  
pp. 1-8 ◽  
Author(s):  
Jin-shan Feng ◽  
Jin-yu Li ◽  
Xiu-yan Chen ◽  
Zheng Yang ◽  
Shang-hai Li
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Meta Analysis ◽  
Credible Interval ◽  
Ileal Resection ◽  
Randomized Controlled ◽  
Endoscopic Recurrence ◽  
Central Database ◽  
Lactobacillus Gg

Objective. To assess the benefits of different treatments that aim to prevent the endoscopic recurrence of Crohn’s disease (CD) after ileal resection. Methods. Randomized controlled trials (RCTs) were searched from MEDLINE, Embase, and the Cochrane Central Database. All the included RCTs with an endoscopic recurrence outcome which was defined as Rutgeerts’ score ≥ i2 have a duration of more than 1 year. The quality of the included RCTs was assessed by the Cochrane Risk of Bias Tool. Pairwise treatment effects were estimated through a Bayesian random effects network meta-analysis by using the OpenBUGS 1.4 software and reported as odds ratios (ORs) with a 95% credible interval (CI). Results. Fourteen RCTs (877 participants) were included. Two strategies were superior to placebo for preventing endoscopic recurrence of CD at 1 year after surgery: infliximab (d, −5.475; 95% CI, −10.47 to –1.632) and adalimumab (d, −7.273; 95% CI, −13.84 to −2.585). Nine strategies were not effective: budesnoid, mesalazine (in both high and low dose), azathioprine, Tripterygium wilfordii, mesalazine + infliximab, ornidazole, untreated intervention, and Lactobacillus GG. Conclusions. Except for infliximab and adalimumab, other strategies included in our analysis were not effective for preventing endoscopic recurrence of CD at 1 year after ileal resection.

scholarly journals P389 Low-dose metronidazole is associated with a decreased rate of endoscopic recurrence of Crohn's disease after ileal resection

2017 ◽  
Vol 11 (suppl_1) ◽  
pp. S275-S275
Author(s):  
L. Glick ◽  
P.H. Sossenheimer ◽  
A. Hirsch ◽  
R.D. Hurst ◽  
R.D. Cohen ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Low Dose ◽  
Ileal Resection ◽  
Endoscopic Recurrence

M1207 A Randomized Controlled Trial of VSL#3 for the Prevention of Endoscopic Recurrence Following Surgery for Crohn's Disease

2008 ◽  
Vol 134 (4) ◽  
pp. A-361 ◽  
Author(s):  
Karen Madsen ◽  
Jody L. Backer ◽  
Des Leddin ◽  
Levinus A. Dieleman ◽  
Alain Bitton ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Controlled Trial ◽  
Randomized Controlled ◽  
Endoscopic Recurrence

Phenotypic Predictors of Endoscopic Recurrence after Ileal Resection for Crohn'S Disease: An Niddk IBD Genetics Consortium Prospective Study

2017 ◽  
Vol 152 (5) ◽  
pp. S366 ◽  
Author(s):  
Karen Boland ◽  
Dermot McGovern ◽  
Talin Haritunians ◽  
Steven R. Brant ◽  
Yashoda Sharma ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Prospective Study ◽  
Ileal Resection ◽  
Endoscopic Recurrence

Low-Dose Metronidazole is Associated with a Decreased Rate of Endoscopic Recurrence of Crohn's Disease after Ileal Resection

2017 ◽  
Vol 152 (5) ◽  
pp. S774-S775
Author(s):  
Laura Glick ◽  
Philip H. Sossenheimer ◽  
Ayal Hirsch ◽  
Roger Hurst ◽  
Russell D. Cohen ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Low Dose ◽  
Ileal Resection ◽  
Endoscopic Recurrence

The relationship between endoscopic and clinical recurrence in postoperative Crohn’s disease: a systematic review and meta-analysis

2021 ◽  
Author(s):  
Alessandro Ble ◽  
Cecilia Renzulli ◽  
Fabio Cenci ◽  
Maria Grimaldi ◽  
Michelangelo Barone ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Cohort Studies ◽  
Meta Analysis ◽  
Mixed Effects ◽  
Spearman Correlation ◽  
Clinical Recurrence ◽  
Endoscopic Recurrence ◽  
Meta Regression ◽  
The Relationship

Abstract Background and Aims We aimed to quantify the magnitude of the association between endoscopic recurrence and clinical recurrence [symptom relapse] in patients with postoperative Crohn’s disease. Methods Databases were searched to October 2, 2020 for randomised controlled trials [RCTs] and cohort studies of adult patients with Crohn’s disease with ileocolonic resection and anastomosis. Summary effect estimates for the association between clinical recurrence and endoscopic recurrence were quantified by risk ratios [RR] and 95% confidence intervals [95% CI]. Mixed-effects meta-regression evaluated the role of confounders. Spearman correlation coefficients were calculated to assess the relationship between these outcomes as endpoints in RCTs. An exploratory mixed-effects meta-regression model with the logit of the rate of clinical recurrence as the outcome and the rate of endoscopic recurrence as a predictor was also evaluated. Results Thirty-seven studies [N=4053] were included. For 8 RCTs with available data, the RR for clinical recurrence for patients who experienced endoscopic recurrence was 10.77 [95% CI 4.08-28.40; GRADE moderate certainty evidence]; the corresponding estimate from 11 cohort studies was 21.33 [95% CI 9.55-47.66; GRADE low certainty evidence]. A single cohort study showed a linear relationship between Rutgeerts score and clinical recurrence risk. There was a strong correlation between endoscopic recurrence and clinical recurrence treatment effect estimates as trial outcomes [weighted Spearman correlation coefficient 0.51]. Conclusions The associations between endoscopic recurrence and subsequent clinical recurrence lend support to the choice of endoscopic recurrence to monitor postoperative disease activity and as a primary endpoint in clinical trials of postoperative Crohn’s disease.

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