scholarly journals Immunotherapy with CAR-Modified T Cells: Toxicities and Overcoming Strategies

2018 ◽  
Vol 2018 ◽  
pp. 1-10 ◽  
Author(s):  
Shangjun Sun ◽  
He Hao ◽  
Ge Yang ◽  
Yi Zhang ◽  
Yang Fu
Keyword(s):  
T Cells ◽  
Potential Treatment ◽  
Antigen Receptors ◽  
Chimeric Antigen Receptors ◽  
Suicide Genes ◽  
Innovative Strategies ◽  
B Cell Malignancy ◽  
Promising Treatment ◽  
New Form ◽  
Cell Malignancy

T cells modified via chimeric antigen receptors (CARs) have emerged as a promising treatment modality. Unparalleled clinical efficacy recently demonstrated in refractory B-cell malignancy has brought this new form of adoptive immunotherapy to the center stage. Nonetheless, its current success has also highlighted its potential treatment-related toxicities. The adverse events observed in the clinical trials are described in this review, after which, some innovative strategies developed to overcome these unwanted toxicities are outlined, including suicide genes, targeted activation, and other novel strategies.

scholarly journals Tolerance and efficacy of autologous or donor-derived T cells expressing CD19 chimeric antigen receptors in adult B-ALL with extramedullary leukemia

2015 ◽  
Vol 4 (11) ◽  
pp. e1027469 ◽  
Author(s):  
Hanren Dai ◽  
Wenying Zhang ◽  
Xiaolei Li ◽  
Qingwang Han ◽  
Yelei Guo ◽  
...  
Keyword(s):  
T Cells ◽  
Antigen Receptors ◽  
Chimeric Antigen Receptors

Genetic engineering of T cells with chimeric antigen receptors for hematological malignancy immunotherapy

2018 ◽  
Vol 61 (11) ◽  
pp. 1320-1332 ◽  
Author(s):  
Dongdong Ti ◽  
Yunfei Niu ◽  
Zhiqiang Wu ◽  
Xiaobing Fu ◽  
Weidong Han
Keyword(s):  
T Cells ◽  
Genetic Engineering ◽  
Hematological Malignancy ◽  
Antigen Receptors ◽  
Chimeric Antigen Receptors

scholarly journals T cells expressing CD123-specific chimeric antigen receptors exhibit specific cytolytic effector functions and antitumor effects against human acute myeloid leukemia

Blood ◽  
2013 ◽  
Vol 122 (18) ◽  
pp. 3138-3148 ◽  
Author(s):  
Armen Mardiros ◽  
Cedric Dos Santos ◽  
Tinisha McDonald ◽  
Christine E. Brown ◽  
Xiuli Wang ◽  
...  
Keyword(s):  
T Cells ◽  
Myeloid Leukemia ◽  
Autologous Tumor ◽  
Antigen Receptors ◽  
Chimeric Antigen Receptors ◽  
Antitumor Effects ◽  
Effector Functions ◽  
Key Points ◽  
Car T ◽  
Human Acute Myeloid Leukemia

Key Points CD123 CAR T cells specifically target CD123+ AML cells. AML patient-derived T cells can be genetically modified to lyse autologous tumor cells.

scholarly journals Redirecting Specificity of T cells Using the Sleeping Beauty System to Express Chimeric Antigen Receptors by Mix-and-Matching of VL and VH Domains Targeting CD123+ Tumors

PLoS ONE ◽  
2016 ◽  
Vol 11 (8) ◽  
pp. e0159477 ◽  
Author(s):  
Radhika Thokala ◽  
Simon Olivares ◽  
Tiejuan Mi ◽  
Sourindra Maiti ◽  
Drew Deniger ◽  
...  
Keyword(s):  
T Cells ◽  
Sleeping Beauty ◽  
Antigen Receptors ◽  
Chimeric Antigen Receptors

Engineered regulatory T cells expressing myelin-specific chimeric antigen receptors suppress EAE progression

2020 ◽  
Vol 358 ◽  
pp. 104222
Author(s):  
Alessandra De Paula Pohl ◽  
Anja Schmidt ◽  
Ai-Hong Zhang ◽  
Tania Maldonado ◽  
Christoph Königs ◽  
...  
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Antigen Receptors ◽  
Chimeric Antigen Receptors

scholarly journals ICOS-based chimeric antigen receptors program bipolar TH17/TH1 cells

Blood ◽  
2014 ◽  
Vol 124 (7) ◽  
pp. 1070-1080 ◽  
Author(s):  
Sonia Guedan ◽  
Xi Chen ◽  
Aviv Madar ◽  
Carmine Carpenito ◽  
Shannon E. McGettigan ◽  
...  
Keyword(s):  
T Cells ◽  
Effector Function ◽  
Th1 Cells ◽  
Antigen Receptors ◽  
Chimeric Antigen Receptors ◽  
Effector Functions ◽  
Key Points

Key Points ICOS-based CARs program bipolar TH17/TH1 cells with augmented effector function and in vivo persistence. The expression of selected CAR endodomains can program T cells for their subsequent differentiation fates and effector functions.

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