scholarly journals Retrospective Analysis of Endocrine Dysfunctions in a Population of Adult Polytransfused Patients: Correlation of GH-IGF1 Axis Alteration with Cardiac Performance

2018 ◽  
Vol 2018 ◽  
pp. 1-7
Author(s):  
Michela Rosaria Campo ◽  
Anna Farese ◽  
Michele Correale ◽  
Giuseppe Berti ◽  
Michela Massa ◽  
...  
Keyword(s):  
Intervention Study ◽  
Adult Population ◽  
Cardiac Performance ◽  
Arginine Test ◽  
Hormonal Evaluation ◽  
The Impact ◽  
Ghrh Plus Arginine Test ◽  
Gh Deficit ◽  
Endocrine Complications

Endocrine complications of haemochromatosis and heart failure mostly affect morbidity and mortality in polytransfused patients. This study analyzes endocrine dysfunctions and the impact of GH-IGF-1 axis alteration on cardiac performance in a population of 31 patients. A retrospective study on 31 Caucasian polytransfused outpatients, 27 adults and 4 pediatric, residing in Apulia, Italy, followed from 2005 to 2016, was conducted. Patients underwent basal and dynamic hormonal evaluation. GHRH plus arginine test was performed in 21 patients (19 adults and 2 children). Among them, 9 patients were affected by left ventricle diastolic dysfunction and/or atrial or ventricular dilatation (HD group) and 12 patients did not have cardiovascular disease (non-HD group). Twenty-nine out of 31 patients (94%) had at least one endocrinopathy. We found severe or mild GH deficit (GHD) in all HD patients versus 3 patients in the non-HD group (p=0.001). Mean IGF-1 levels were significantly lower in the HD group than in non-HD subjects (53±30 versus 122±91 μg/L, p=0.04). Our study confirms the need to perform a dynamic evaluation of the GH-IGF1 axis in polytransfused patients, especially when heart dysfunction emerges. An intervention study with GH replacement therapy in a larger randomized adult population will clarify the role of GH/IGF axis on cardiovascular outcomes in this patient population.

Promoting morphological awareness in Hebrew-speaking grade-schoolers: An intervention study using linguistic humor

2009 ◽  
Vol 29 (1) ◽  
pp. 81-112 ◽  
Author(s):  
Dorit Ravid ◽  
Vital Geiger
Keyword(s):  
Intervention Program ◽  
Intervention Study ◽  
Intervention Group ◽  
Morphological Awareness ◽  
Literacy Acquisition ◽  
Intervention Programs ◽  
Intervention Period ◽  
Semitic Language ◽  
The Impact

Research indicates that morphological awareness contributes to success in literacy acquisition and consolidation, since morphology links together phonological and semantic facets of language. The role of morphology is especially important in Hebrew, a highly synthetic Semitic language. The current study aimed to investigate the impact of an intervention program on knowledge and awareness of morphology in Hebrew-speaking grade-schoolers. Two three-month intervention programs were conducted in two groups of 4th-grade children: a metalinguistic morphological intervention program using linguistic humor, and a parallel intervention program using nonverbal humor. A morphological awareness test was administered to the two groups prior to and following the intervention period. The results demonstrate consistent advantages to the morphological intervention group, including tasks related both directly and indirectly to content taught.

Life-Threatening Injuries in Older Adults

2011 ◽  
Vol 22 (2) ◽  
pp. 128-139
Author(s):  
Linda J. Scheetz
Keyword(s):  
Older Adults ◽  
Motor Vehicle ◽  
Metabolic Response ◽  
Adult Population ◽  
Goal Directed Therapy ◽  
The Us ◽  
Life Threatening ◽  
Older Adult Population ◽  
The Impact

Unintentional injuries are among the leading causes of death and disability in older adults. Although older adults account for approximately 12% of the US population, in 2008, they accounted for 15% of all traffic fatalities, 14% of all vehicle occupant fatalities, and 18% of all pedestrian fatalities. Severely injured older adults have far worse outcomes than younger adults. Despite this difference, many survive with aggressive resuscitation and goal-directed therapy. This article describes the impact of life-threatening injuries in the older adult population, specifically injuries sustained in motor vehicle collisions, and how these injuries relate to anatomic and physiologic changes of aging, the metabolic response to injury, the role of preexisting diseases and medications taken to treat these diseases, and complications.

Intergroup Threat and Outgroup Attitudes

2013 ◽  
Vol 44 (5) ◽  
pp. 311-319 ◽  
Author(s):  
Marco Brambilla ◽  
David A. Butz
Keyword(s):  
Gay Men ◽  
Social Group ◽  
Welfare Recipients ◽  
Intergroup Attitudes ◽  
Social Policies ◽  
Intergroup Threat ◽  
Economic Threat ◽  
The Impact ◽  
General Climate

Two studies examined the impact of macrolevel symbolic threat on intergroup attitudes. In Study 1 (N = 71), participants exposed to a macrosymbolic threat (vs. nonsymbolic threat and neutral topic) reported less support toward social policies concerning gay men, an outgroup whose stereotypes implies a threat to values, but not toward welfare recipients, a social group whose stereotypes do not imply a threat to values. Study 2 (N = 78) showed that, whereas macrolevel symbolic threat led to less favorable attitudes toward gay men, macroeconomic threat led to less favorable attitudes toward Asians, an outgroup whose stereotypes imply an economic threat. These findings are discussed in terms of their implications for understanding the role of a general climate of threat in shaping intergroup attitudes.

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