scholarly journals Graft Survival after Penetrating Keratoplasty in Cases of Trabeculectomy versus Ahmed Valve Implant

2018 ◽  
Vol 2018 ◽  
pp. 1-6 ◽  
Author(s):  
Abdelhamid Elhofi ◽  
Hany Ahmed Helaly
Keyword(s):  
Mitomycin C ◽  
Graft Survival ◽  
Graft Failure ◽  
Penetrating Keratoplasty ◽  
Anterior Segment ◽  
Group Versus ◽  
Corneal Graft ◽  
Ahmed Glaucoma Valve ◽  
Significant Difference ◽  
Corneal Graft Failure

Purpose. To compare the corneal graft survival rates after penetrating keratoplasty (PKP) in cases of post-PKP glaucoma managed by either trabeculectomy with mitomycin C or Ahmed glaucoma valve (AGV). Methods. This study was a retrospective interventional comparative study that included 40 eyes of 40 patients. The included patients had undergone previous PKP for anterior segment reconstruction after microbial or fungal keratitis, chemical burns, trauma, or perforated corneal ulcer. Post-PKP glaucoma was managed surgically by either trabeculectomy with mitomycin C (group 1) or Ahmed glaucoma valve (group 2). Results. The first group n=20 had undergone trabeculectomy with MMC, and the second group n=20 had undergone AGV implantation. Regarding BCVA, there was no statistically significant difference between the 2 groups. Mean IOP was significantly lower in the AGV group at 6 months, 12 months, and 24 months p=0.001. Mean IOP at 24 months dropped significantly from preglaucoma surgery levels in both groups p=0.001. Rejection episodes occurred in 2 eyes (10%) of the trabeculectomy group versus 8 eyes (40%) in the AGV group p=0.028. In the trabeculectomy group, corneal graft failure occurred in 1 (5%), 3 (15%), and 6 (30%) eyes at 6 months, 12 months, and 24 months, respectively. In the AGV group, corneal graft failure occurred in 2 (10%), 5 (25%), and 10 (50%) eyes at 6 months, 12 months, and 24 months, respectively. The mean time to failure in the trabeculectomy group was 12.33 ± 5.60 months versus 11.90 ± 5.70 months in the AGV group p=0.027. Conclusion. Managing postpenetrating keratoplasty glaucoma could be bothersome especially in complex cases. Ahmed glaucoma valve implant controls the intraocular pressure more effectively than trabeculectomy with mitomycin C. However, Ahmed glaucoma valve can result in higher rates of corneal graft failure in a shorter duration of time. This trial is registered with PACTR201712002861391 on 21 Dec 2017.

scholarly journals Risk factors for corneal graft failure and rejection in penetrating keratoplasty

2001 ◽  
Vol 79 (3) ◽  
pp. 251-255 ◽  
Author(s):  
Kenji Inoue ◽  
Shiro Amano ◽  
Tetsuro Oshika ◽  
Tadahiko Tsuru
Keyword(s):  
Risk Factors ◽  
Graft Failure ◽  
Penetrating Keratoplasty ◽  
Corneal Graft ◽  
Corneal Graft Failure

scholarly journals Keratoprosthesis, Dohlman Type I device for a patient with repeated corneal graft failure

1970 ◽  
Vol 4 (1) ◽  
pp. 165-169 ◽  
Author(s):  
L Bajracharya ◽  
R Gurung ◽  
G Tabin
Keyword(s):  
Graft Survival ◽  
Poor Prognosis ◽  
Graft Failure ◽  
Penetrating Keratoplasty ◽  
Type I ◽  
First Case ◽  
Corneal Blindness ◽  
Type Of Surgery ◽  
Patients With Poor Prognosis ◽  
Corneal Graft Failure

Background: Keratoprosthesis (Kpro) surgery is performed in patients in whom traditional penetrating keratoplasty (PK) surgery has no hope for graft survival. The burden of corneal blindness is high in a developing country like Nepal. Case: A thirty-year-old man, with multiple graft failure in his only eye, underwent Kpro surgery. He had ambulatory vision and a stable Kpro 29 months after the surgery. Conclusion: Kpro surgery has been introduced in the country with this as the first case. Patients with poor prognosis for PK can benefit from this type of surgery. DOI: http://dx.doi.org/10.3126/nepjoph.v4i1.5869 NEPJOPH 2012; 4(1): 165-169

Outcomes of Pars Plana Vitrectomy in Combination With Penetrating Keratoplasty

2017 ◽  
Vol 1 (2) ◽  
pp. 116-121 ◽  
Author(s):  
Randee Miller Watson ◽  
Sherif Dawood ◽  
Dingcai Cao ◽  
William F. Mieler ◽  
Yannek I. Leiderman
Keyword(s):  
Pars Plana Vitrectomy ◽  
Graft Failure ◽  
Penetrating Keratoplasty ◽  
Silicone Oil ◽  
Corneal Transplantation ◽  
Corneal Graft ◽  
Minimum Angle ◽  
Pars Plana ◽  
Corneal Decompensation ◽  
Corneal Graft Failure

Purpose: To report indications and outcomes of combined pars plana vitrectomy and penetrating keratoplasty (PPV-PKP). Methods: A review of all patients who underwent PPV-PKP at the Illinois Eye and Ear Infirmary from January 1, 2001 to May 31, 2013, was performed. Ninety eyes of 90 patients were identified. Survival analysis was utilized to assess differences in retinal detachment (RD) and corneal graft failure rates among groups based on clinical and surgical variables. Results: Seventy-nine eyes met the inclusion criteria. Most common indications for vitrectomy and corneal transplantation were RD (65%) and corneal decompensation (43%), respectively. The preoperative and final visual acuity (VA) logarithm of the minimum angle of resolution values were 2.7 (0.31) and 2.5 (0.67) (hand motions; mean [SD]; P = .02); 15% of eyes were ≥20/400 and 15% gained ≥2 lines of vision following surgery. Corneal graft failure occurred in 51% (40 eyes), recurrent RD in 28% (22 eyes), and hypotony in 25% (20 eyes). Silicone oil endotamponade was associated with postoperative RD ( P = .045), and previous ocular trauma was associated with postoperative corneal graft failure ( P = .023). Conclusion: Combined PPV-PKP surgery was likely to achieve stabilization of VA, with a minority of eyes achieving modest gains in VA.

Effectiveness of Histocompatibility Matching in High-Risk Corneal Transplantation

2020 ◽  
pp. 1-8
Author(s):  
Alan D. Penman ◽  
Kimberly W. Crowder ◽  
William M. Watkins
Keyword(s):  
High Risk ◽  
Graft Failure ◽  
Corneal Transplantation ◽  
Corneal Graft ◽  
Hla Dr ◽  
Risk Patients ◽  
Graft Success ◽  
Group Matching ◽  
Corneal Graft Failure

The Collaborative Cornea Transplant Studies (CCTS) comprised two randomized, double-masked, clinical trials, the Antigen Matching Study (AMS) and the Crossmatch Study (CS), designed to determine whether matching HLA-A, -B, and/or HLA-DR antigens, donor-recipient crossmatching, or ABO compatibility reduced the risk of corneal allograft rejection and failure in high-risk patients. The studies showed that for patients needing a corneal graft with uncompromised immune systems and at high risk for corneal graft rejection: (1) neither HLA-A, -B, nor HLA-DR antigen matching substantially reduces the likelihood of corneal graft failure; (2) a positive donor-recipient crossmatch does not dramatically increase the risk of corneal graft failure; and (3) ABO blood group matching may be effective in reducing the risk of graft failure. Intensive steroid therapy after transplantation, frequent follow-up, medication and follow-up compliance, and patient education appear to play a significant role in corneal graft success.

scholarly journals Clinical Outcomes of Penetrating Keratoplasty and Descemet Stripping Automated Endothelial Keratoplasty in Asian Population with American Corneas

2019 ◽  
Vol 16 (22) ◽  
pp. 4547 ◽  
Author(s):  
Hsiao ◽  
Chen ◽  
Meir ◽  
Tan ◽  
Hsiao ◽  
...  
Keyword(s):  
Survival Rate ◽  
Graft Survival ◽  
Penetrating Keratoplasty ◽  
Survival Rates ◽  
Asian Population ◽  
Chang Gung Memorial Hospital ◽  
Endothelial Keratoplasty ◽  
Significant Difference ◽  
Donor Corneas

To determine the comparative efficacy and safety of penetrating keratoplasty (PK) and Descemet stripping automated endothelial keratoplasty (DSAEK) in the Asian population receiving imported donor corneas, our single-center retrospective study provides analysis supporting the transition from PK to DSAEK in the Asian population using imported American donor corneas. We analyzed 259 patients with 241 and 57 cases of PK and DSAEK respectively during 2008 to 2017 using imported corneas at Chang Gung Memorial Hospital, Linkou, Taiwan. In terms of long-term graft survival analysis, there was no difference between PK and DSAEK (log-rank p = 0.386, HR = 0.920, 95% CI: [0.641–1.380]). However, Cox proportional regression analysis revealed that corneal survival rate of DSAEK group in the first 100 days after transplantation was inferior than that of PK group (log-rank p < 0.001, HR = 2.733, 95% CI: [1.501–4.977])]. Despite the inferior survival rate, there were significantly less neovascularization and Descemet membrane folds in the DSAEK group. Importantly, the non-complication rate of DSAEK was much higher than that of PK with significant difference (PK, 25.7% vs DSAEK 42.0%, p = 0.022). Collectively, DSAEK is suggested as an alternative surgical modality in Asian patients using imported American donor corneas because of less complication, and no difference in long-term corneal graft survival rates between PK and DSAEK.

Primary Corneal Graft Failure

1995 ◽  
Vol 113 (12) ◽  
pp. 1554 ◽  
Author(s):  
Frederick S. Brightbill
Keyword(s):  
Graft Failure ◽  
Corneal Graft ◽  
Corneal Graft Failure
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