scholarly journals Oral Lichenoid Reaction: An Uncommon Side Effect of Rituximab

2019 ◽  
Vol 2019 ◽  
pp. 1-3 ◽  
Author(s):  
Amerigo Giudice ◽  
Francesco Liborio ◽  
Fiorella Averta ◽  
Selene Barone ◽  
Leonzio Fortunato
Keyword(s):  
Side Effect ◽  
Oral Lichen Planus ◽  
Drug Exposure ◽  
B Cell Lymphoma ◽  
Systemic Drug Exposure ◽  
Lichenoid Reactions ◽  
The Right ◽  
Oral Lichen ◽  
Histopathological Result ◽  
Systemic Drug

Oral lichenoid reactions (OLR) can be caused by systemic drug exposure. To the best of our knowledge, this is the second report describing a case of OLR induced by rituximab administration in a patient with a diagnosis of non-Hodgkin B-cell lymphoma. After 5 doses of rituximab, a typical pattern of OLP was identified with bilateral and symmetrical lesions on the buccal mucosa and on the right lingual margin. This temporal relationship suggested a probable association between oral lesions and drug therapy. The clinical diagnosis of a rituximab-induced OLR was confirmed by an incisional biopsy reporting a histopathological result of lichenoid mucositis consistent with oral lichen planus. Because of the increasing use of rituximab, it is necessary to know and recognize this uncommon side effect.

scholarly journals Intrathecal Riluzole for the Treatment of Patients With Amyotrophic Lateral Sclerosis

Neurosurgery ◽  
2019 ◽  
Vol 66 (Supplement_1) ◽  
Author(s):  
Nicholas M Boulis
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Side Effects ◽  
Oral Administration ◽  
Oral Therapy ◽  
Drug Exposure ◽  
Oral Treatment ◽  
Oral Drug ◽  
Systemic Drug Exposure ◽  
Lateral Sclerosis ◽  
Systemic Drug

Abstract INTRODUCTION Oral riluzole is the only approved treatment known to improve survival in patients with amyotrophic lateral sclerosis (ALS), with modest efficacy and dosing limited by hepatic toxicity and asthenia. We postulated that a continuous intrathecal (IT) delivery of low daily doses of riluzole could elevate spinal cord (SC) concentrations well above those achievable with oral treatment alone, without increasing side-effects. METHODS A 6-wk and a 24-wk GLP study were conducted to evaluate the safety of IT riluzole in purpose-bred hound dogs. Oral riluzole, equivalent to 50 mg BID in humans, was administered in combination with one of 3 IT doses given through continuous infusion. Plasma, SC, and brain concentrations of riluzole were measured, along with assessments of safety and tolerability. RESULTS In the 6-wk study, when combining the oral and IT routes, IT infusion significantly increased SC concentrations well above those achieved with oral drug administration alone, without increasing brain concentrations. All IT doses in combination with oral administration were well tolerated by the animals. In the 6-mo study, the lowest dose used in the 6-wk study was dropped and a higher dose was added. This highest dose of IT riluzole was not tolerated by the dogs and yielded SC and brain concentrations significantly higher than achieved in any of our previous studies. CONCLUSION Continuous IT administration of riluzole when combined with oral administration can increase the SC concentration of riluzole above those achievable with oral therapy, without increasing the risk for adverse events associated with systemic drug exposure or off-target side-effects in the brain. Therefore, IT riluzole infusion when used in conjunction with oral therapy may safely enhance lower motor neuron neuroprotection and improve the survival benefit of the drug through enhanced SC delivery, and, with a careful selection of IT doses, it could be implemented in patients with ALS.

Phase I trial of concurrent intraperitoneal and continuous intravenous infusion of fluorouracil in patients with refractory cancer.

1988 ◽  
Vol 6 (1) ◽  
pp. 158-162 ◽  
Author(s):  
B Reichman ◽  
M Markman ◽  
T Hakes ◽  
N Kemeny ◽  
D Kelsen ◽  
...  
Keyword(s):  
Phase I ◽  
Intravenous Infusion ◽  
Phase I Study ◽  
Clinical Utility ◽  
Phase I Trial ◽  
Drug Exposure ◽  
Continuous Intravenous Infusion ◽  
Future Studies ◽  
Systemic Drug Exposure ◽  
Systemic Drug

In an effort to maximize both local-regional and systemic drug exposure to tumor in the peritoneal cavity, a phase I study was conducted that examined the simultaneous daily intraperitoneal (IP) and continuous intravenous infusion (CVI) of fluorouracil (5-FU) to 32 patients with refractory cancer. IP 5-FU administered at 1,000 mg/d with concurrent 5-FU by CVI at 1,000 mg/m2/d for four consecutive days was well tolerated. One patient with a primary gastrointestinal (GI) malignancy with minimal volume disease experienced a surgically defined complete remission. In theory, this regimen may demonstrate clinical utility as an adjuvant treatment of certain GI malignancies. Future studies are planned in this clinical setting.

Increased doxorubicin levels in hepatic tumors with reduced systemic drug exposure achieved with complete hepatic venous isolation and extracorporeal chemofiltration

1993 ◽  
Vol 33 (3) ◽  
pp. 251-257 ◽  
Author(s):  
Steven A. Curley ◽  
Diana L. Stone ◽  
George M. Fuhrman ◽  
David C. Hohn ◽  
Zahid H. Siddik ◽  
...  
Keyword(s):  
Drug Exposure ◽  
Hepatic Tumors ◽  
Systemic Drug Exposure ◽  
Systemic Drug

Patch testing in lichenoid reactions of the mouth and oral lichen planus

1990 ◽  
Vol 23 (4) ◽  
pp. 300-300 ◽  
Author(s):  
P. Todd ◽  
J. Garioch ◽  
P. J. Lamey ◽  
M. Lewis ◽  
A. Forsyth ◽  
...  
Keyword(s):  
Lichen Planus ◽  
Patch Testing ◽  
Oral Lichen Planus ◽  
Lichenoid Reactions ◽  
Oral Lichen

scholarly journals Degranulated mast cells and TNF-α in oral lichen planus and oral lichenoid reactions diseases

2012 ◽  
Vol 1 (1) ◽  
pp. 52 ◽  
Author(s):  
Zahra Saberi ◽  
Parichehr Ghalayani ◽  
Gholamreza Jahanshahi
Keyword(s):  
Mast Cells ◽  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Tnf Α ◽  
Lichenoid Reactions ◽  
Oral Lichen

scholarly journals Oral lichen planus and oral lichenoid reactions: a retrospective evaluation of patch test results with dental series

Mucosa ◽  
2021 ◽  
pp. 17-22
Author(s):  
Burcu AYDEMİR ◽  
Leyla BAYKAL SELÇUK ◽  
Deniz AKSU ARICA ◽  
Ali Osman METİNTAŞ
Keyword(s):  
Patch Test ◽  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Test Results ◽  
Retrospective Evaluation ◽  
Lichenoid Reactions ◽  
Oral Lichen

scholarly journals Symmetrical drug-related intertriginous and flexural exanthema due to clindamycin

2019 ◽  
Vol 12 (8) ◽  
pp. e230077 ◽  
Author(s):  
Virginia Cabrera Hernandez ◽  
Monica Gonzalez Afonso ◽  
Ariel Callero Viera ◽  
Lidon Martin-Fernandez Martin
Keyword(s):  
Drug Exposure ◽  
Systemic Exposure ◽  
Standard Test ◽  
Skin Tests ◽  
Hypersensitivity Response ◽  
Cutaneous Eruption ◽  
Systemic Involvement ◽  
Gold Standard Test ◽  
Systemic Drug Exposure ◽  
Systemic Drug

Systemic drug exposure can produce a skin reaction consisting of symmetrical erythema involving the gluteal and intertriginous areas in the absence of systemic involvement. Symmetrical drug-related intertriginous and flexural exanthema (SDRIFE) occurs after systemic exposure to a drug in which the patient was not previously sensitised, either in the first dose or after several doses. The mechanism of SDRIFE is unknown but is hypothesised to be the result of a delayed hypersensitivity response resulting in a cutaneous eruption some days after the exposure to the drug. The diagnosis should be clinical, based on the history and examination, but skin tests can also be performed to confirm sensitisation. But, as always, the gold-standard test is oral provocation. It is important to know this clinical entity to prevent re-exposure to the responsible allergen in the future.

Sign in / Sign up

Export Citation Format

Share Document