Impact of Molybdenum Compounds as Anticancer Agents

The aim of this mini review was to report the molybdenum compound intervention to control cancer disease. The intervention explains its roles and progress from inorganic molybdenum compounds via organomolybdenum complexes to its nanoparticles to control oesophageal cancer and breast cancer as case studies. Main contributions of molybdenum compounds as anticancer agents could be observed in their nanofibrous support with suitable physicochemical properties, combination therapy, and biosensors (biomarkers). Recent areas in anticancer drug design, which entail the uses of selected targets, were also surveyed and proposed.

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Targeted photoresponsive TiO2–coumarin nanoconjugate for efficient combination therapy in MDA-MB-231 breast cancer cells: synergic effect of photodynamic therapy (PDT) and anticancer drug chlorambucil

MedChemComm ◽

10.1039/c4md00481g ◽

2015 ◽

Vol 6 (5) ◽

pp. 769-777 ◽

Cited By ~ 12

Author(s):

Moumita Gangopadhyay ◽

Sourav K. Mukhopadhyay ◽

S. Karthik ◽

Shrabani Barman ◽

N. D. Pradeep Singh

Keyword(s):

Breast Cancer ◽

Photodynamic Therapy ◽

Combination Therapy ◽

Cancer Cells ◽

Anticancer Drug ◽

Breast Cancer Cells ◽

Single Component ◽

Synergic Effect ◽

Nanoparticle System ◽

First Time

We have developed for the first time an excellent targeted metallic single component nanoparticle system for combination of PDT and chemotherapy.

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Study of Selected Flavonoid Structures and Their Potential Activity as Breast Anticancer Agents

Cancer Informatics ◽

10.1177/11769351211055160 ◽

2021 ◽

Vol 20 ◽

pp. 117693512110551

Author(s):

Mohammed Hadi Ali Al-Jumaili ◽

Muqdad Khairi Yahya Al hdeethi

Keyword(s):

Breast Cancer ◽

Anticancer Agents ◽

Antitumor Agent ◽

Cancer Drug ◽

Molecular Characteristics ◽

Cancer Disease ◽

Chemopreventive Agents ◽

Natural Substances ◽

Antioxidant Agent ◽

Potential Activity

Flavonoids contain pharmacological effects that help to protect cells from damage. However, the anticancer activity of flavonoids is related to their modulation of signal transduction pathways within cancer cells. Natural substances such as flavonoids have immune-stimulating anti-tumor effect that could lower breast cancer risk. However, various diseases included Alzheimer’s and cancer disease are associated with flavonoids intake due to their ability as antioxidant agent to alter essential cellular enzyme’s function. Therefore, through interaction between flavonoids and Cytochrome P450 (CYP) family enzymes led to make them chemopreventive agents for breast cancer. In this analysis, the chemo-informatics properties of 5 selective flavonoid derivatives and their efficiency as anti-breast cancer drugs were evaluated. Flavonoid ligands were docked with the predicted protein, which is human placental aromatase complexes with exemestane, a breast cancer drug (3S7S). Based on various docking energies, the molecular characteristics and bioactivity score of the following components, C15H12O6 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-2,3-dihydro-4H-chromen-4-one and C15H12O5 5,8-dihydroxy-2-(4-hydroxyphenyl)-2,3-dihydro-4H-chromen-4-one showed greatest molecular properties and bioactivity docking scores of −8.633117 and −8.633117 kcal/mol respectively. Therefore, both compounds could be considered antitumor agent.

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