Drug Coated Balloon-Only Strategy in De Novo Lesions of Large Coronary Vessels

Objectives. We analyzed the efficacy of drug coated balloons (DCB) as a stand-alone-therapy in de novo lesions of large coronary arteries. DCBs seem to be an attractive alternative for the stent-free interventional treatment of de novo coronary artery disease (CAD). However, data regarding a DCB-only approach in de novo CAD are currently limited to vessels of small caliber. Methods. By means of propensity score (PS) matching 234 individuals with de novo CAD were identified with similar demographic characteristics. This patient population was stratified in a 1:1 fashion according to a reference vessel diameter cut-off of 2.75 mm in small and large vessel disease. The primary endpoint was the rate of clinically driven target lesion revascularization (TLR) at 9 months. Results. Patients with small vessel disease had an average reference diameter of 2.45 ± 0.23 mm, while the large vessel group averaged 3.16 ± 0.27 mm. Regarding 9-month major adverse cardiac event (MACE), 5.7% of the patients with small and 6.1% of the patients with large vessels had MACE (p=0.903). Analysis of the individual MACE components revealed a TLR rate of 3.8% in small and 1.0% in large vessels (p=0.200). Of note, no thrombotic events in the DCB treated coronary segments occurred in either group during the 9-month follow-up. Conclusions. Our data demonstrate for the first time that DCB-only PCI of de novo lesions in large coronary arteries (>2.75 mm) is safe and as effective. Interventional treatment for CAD without permanent or temporary scaffolding, demonstrated a similar efficacy for large and small vessels.

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Drug-Coated Balloon-Only Angioplasty Outcomes in Diabetic and Nondiabetic Patients with De Novo Small Coronary Vessels Disease

Journal of Interventional Cardiology ◽

10.1155/2021/2632343 ◽

2021 ◽

Vol 2021 ◽

pp. 1-9

Author(s):

Botey Katamu Benjamin ◽

Wenjie Lu ◽

Zhanying Han ◽

Liang Pan ◽

Xi Wang ◽

...

Keyword(s):

De Novo ◽

Small Vessel Disease ◽

Independent Predictor ◽

Coronary Vessels ◽

Target Lesion ◽

Target Lesion Revascularization ◽

Vessel Disease ◽

One Year ◽

Target Lesion Failure ◽

Drug Coated Balloon

Background. The revascularization of small vessels using drug-eluting stents remains challenging. The use of the drug-coated balloon is an attractive therapeutic strategy in de novo lesions in small coronary vessels, particularly in the diabetic group. This study aimed to assess the outcomes of DCB-only angioplasty in small vessel disease. Methods. A total of 1198 patients with small vessel disease treated with DCB-only strategy were followed. Patients were divided into the diabetic and nondiabetic groups. Clinical and angiographical follow-up were organized at 12 months. The primary endpoints were target lesion failure and secondary major adverse cardiac events. Results. There was a significantly higher rate of target lesion failure among diabetic patients compared to nondiabetic [17 (3.9%) vs. 11 (1.4%), P = 0.006 ], taken separately, the rate of target lesion revascularization significantly differed between groups with a higher rate observed in the diabetic group [9 (2%) vs. 4 (0.5%), P = 0.014 ]. Diabetes mellitus remained an independent predictor for TLF (HR: 2.712, CI: 1.254–5.864, P = 0.011 ) and target lesion revascularization (HR: 3.698, CI: 1.112–12.298, P = 0.033 ) after adjustment. However, no significant differences were observed between groups regarding the target vessel myocardial infarction (0.6% vs. 0.1%, P = 0.110 ) and MACE [19 (4.4%) vs. 21 (2.7%), P = 0.120 ]. Conclusion. Drug-coated balloon-only treatment achieved lower incidence rates of TLF and MACE. Diabetes is an independent predictor for target lesion failure and target lesion revascularization at one year following DCB treatment in small coronary vessels. We observed no significant differences between groups regarding MACE in one year.

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LDL phenotype B and other lipid abnormalities in patients with large vessel disease and small vessel disease

Journal of the Neurological Sciences ◽

10.1016/s0022-510x(03)00166-7 ◽

2003 ◽

Vol 214 (1-2) ◽

pp. 11-16 ◽

Cited By ~ 12

Author(s):

Agnieszka Slowik ◽

Tomasz Iskra ◽

Wojciech Turaj ◽

Jadwiga Hartwich ◽

Aldona Dembinska-Kiec ◽

...

Keyword(s):

Small Vessel Disease ◽

Large Vessel ◽

Small Vessel ◽

Vessel Disease ◽

Lipid Abnormalities ◽

Large Vessel Disease

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Large-vessel correlates of cerebral small-vessel disease

Neurology ◽

10.1212/wnl.0b013e318281ccc2 ◽

2013 ◽

Vol 80 (7) ◽

pp. 662-669 ◽

Cited By ~ 69

Author(s):

M. Brisset ◽

P. Boutouyrie ◽

F. Pico ◽

Y. Zhu ◽

M. Zureik ◽

...

Keyword(s):

Small Vessel Disease ◽

Cerebral Small Vessel Disease ◽

Large Vessel ◽

Small Vessel ◽

Vessel Disease

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P2806A novel sirolimus drug eluting stent for Small-Vessel Disease: results from en-ABL e-registry

European Heart Journal ◽

10.1093/eurheartj/ehz748.1118 ◽

2019 ◽

Vol 40 (Supplement_1) ◽

Author(s):

L Testa ◽

S Dani ◽

D Desai ◽

R Pandya ◽

P Parekh ◽

...

Keyword(s):

Stent Thrombosis ◽

Small Vessel Disease ◽

Large Vessel ◽

Small Vessel ◽

Drug Eluting Stent ◽

Vessel Disease ◽

Significant Difference ◽

Myocardial Infraction ◽

Drug Eluting

Abstract Objective The aim of the study was to assess the clinical outcome of Abluminus DES in patients with small vessels. Background Percutaneous coronary intervention (PCI) of small coronary vessel (≤2.75 mm) associated with more chances of restenosis and repeat revascularization even when drug eluting stent employed. Methods A total of 2,500 patients enrolled in en-ABL e-registry which is a prospective, multicentre observational post market registry. Out of 2,500 patients, 1,253 patients had small vessel (SV, ≤2.75 mm) while 1,247 had large vessel (LV, >3mm) disease. The primary endpoint was major adverse cardiac events (MACE) which is composite of cardiac death, target vessel myocardial infraction (TV-MI) and target lesion/vessel revascularization (TLR) at 1 year follow up. The secondary endpoint were stent thrombosis and MACE up to 2 years. Results Baseline characteristics were well matched in both groups. In the SV group had higher prevalence of diabetes as compared to large vessel 43.0% vs 25.7%. Total 1,400 lesions treated with 1,612 Abluminus DES and 1,569 lesions treated with 1,675 Abluminus DES in SV and LV groups respectively. The mean diameter of stent was 2.61±0.23 and 3.3±0.3 mm in SV and LV groups respectively. There was a significant difference in MACE in treatment groups (3.7% vs. 1.4%, p=0.004 respectively) at 1 year. No significant differences were observed between SV and LV groups in terms of death/myocardial infarction or stent thrombosis. There were increment of only one TLR and no stent thrombosis reported at 2-year follow-up. Conclusion This result suggests the efficacy and safety of novel Abluminus DES in small vessel disease.

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P873Plasma PCSK9 levels and atherosclerosis burden in the coronary arteries of patients undergoing coronary angiography

European Heart Journal ◽

10.1093/eurheartj/ehz747.0470 ◽

2019 ◽

Vol 40 (Supplement_1) ◽

Author(s):

Y Panahi ◽

M S Ghahrodi ◽

M S Jamshir ◽

M A Safarpour ◽

M Pirro ◽

...

Keyword(s):

Coronary Artery ◽

Coronary Angiography ◽

Coronary Arteries ◽

Coronary Stenosis ◽

Coronary Vessels ◽

Cross Sectional Study ◽

Cross Sectional ◽

Vessel Disease ◽

Coronary Calcifications ◽

Triple Vessel Disease

Abstract Background Plasma PCSK9 levels, a novel and effective therapeutic target for CVD prevention, have been associated with CVD events irrespective of traditional risk factors. Whether PCSK9 levels predict coronary artery disease (CAD) burden and severity is a matter of dispute. Purpose To investigate the association between plasma PCSK9 levels and CAD characteristics, including number of major diseased vessels, severity of coronary stenosis, and the burden of coronary calcifications. Methods One hundred and one patients undergoing coronary angiography were recruited for this cross-sectional study. The number of major coronary diseased vessels was defined as the presence of ≥1 stenoses ≥50% in diameter of at least one major coronary artery. CAD severity was defined as either the absence of coronary stenosis (no-CAD), CAD<50% or CAD≥50% in one or more coronary arteries. The burden of coronary calcifications was estimated by angiography visual inspection and classified as absent, mild, moderate or severe. Results Coronary angiography showed single, double and triple vessel disease in 26 (25.7%), 23 (22.8%) and 21 (20.8%) patients, respectively; 20 (19.8%) and 11 (10.9%) pts had either minimal CAD (<50%) or normal angiographic findings. Also, calcifications were absent in 65 patients (64.4%), and mild, moderate and severe in 23 (22.8%), 11 (10.9%) and 2 (2%) patients, respectively. Plasma PCSK9 levels were significantly associated with age (rho=0.22, p=0.025) and SBP (rho=0.21, p=0.034), and were almost doubled in patients with chronic kidney disease (CKD) as compared to those without CKD [164.6 ng/mL (104.6–187.0) vs 94.8 ng/mL (86.8–114.9), p=0.006]. Among patients without CKD, those with CAD≥50% had higher plasma PCSK9 levels than those without [97.1 ng/mL (87.8–143.0) vs 83.2 ng/mL (73.4–102.6), p=0.04]. In the overall population, higher plasma PCSK9 levels were found in pts with triple vessel disease [165.7 ng/mL (121.3–180.5)] than in those with double/single vessel involvement [97.9 ng/mL (87.6–99.8) and 88.4 ng/mL (87.3–97.4), p<0.001 for both comparisons] or without CAD [87.5 ng/mL (74.3–114.9), p<0.001]. Also, a trend toward an increase of plasma PCSK9 levels was found with higher CAD severity [no-CAD: 87.5 ng/mL (74.3–114.9), CAD<50%: 89.1 ng/mL (78.9–105.3), CAD≥50%: 97.6 ng/mL (87.9–155.3), p=0.051], which turned significant after exclusion of CKD patients (p=0.042). Adjustment for age, sex, plasma LDL-cholesterol levels, statin use and CKD abolished the association between PCSK9 and CAD severity but not with the number of significantly diseased vessels and the burden of coronary calcifications. Conclusions Circulating PCSK9, whose plasma levels are significantly influenced by the presence of CKD, discriminates patients with significant coronary artery stenosis from those without CAD. In addition, both the number of diseased coronary vessels and total coronary calcifications are independently predicted by an elevated plasma PCSK9 level. Acknowledgement/Funding None

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High On-Treatment Platelet Reactivity Affects the Extent of Ischemic Lesions in Stroke Patients Due to Large-Vessel Disease

Journal of Clinical Medicine ◽

10.3390/jcm9010251 ◽

2020 ◽

Vol 9 (1) ◽

pp. 251 ◽

Cited By ~ 3

Author(s):

Adam Wiśniewski ◽

Joanna Sikora ◽

Agata Sławińska ◽

Karolina Filipska ◽

Aleksandra Karczmarska-Wódzka ◽

...

Keyword(s):

Ischemic Stroke ◽

Small Vessel Disease ◽

Platelet Reactivity ◽

Volume Measurement ◽

Large Vessel ◽

Vessel Disease ◽

Fluid Attenuated Inversion Recovery ◽

The Brain ◽

Large Vessel Disease

Background: Excessive platelet activation and aggregation plays an important role in the pathogenesis of ischemic stroke. Correlation between platelet reactivity and ischemic lesions in the brain shows contradictory results and there are not enough data about the potential role of stroke etiology and its relationships with chronic lesions. The aim of this study is to assess the relationship between platelet reactivity and the extent of ischemic lesions with the particular role of etiopathogenesis. Methods: The study involved 69 patients with ischemic stroke, including 20 patients with large-vessel disease and 49 patients with small-vessel disease. Evaluation of platelet reactivity was performed within 24 h after the onset of stroke using two aggregometric methods (impedance and optical), while ischemic volume measurement in the brain was performed using magnetic resonance imaging (in diffusion-weighted imaging (DWI) and fluid-attenuated inversion recovery (FLAIR) sequences) at day 2–5 after the onset of stroke. Results: In the large-vessel disease subgroup, a correlation was found between platelet reactivity and acute ischemic focus volume (correlation coefficient (R) = 0.6858 and p = 0.0068 for DWI; R = 0.6064 and p = 0.0215 for FLAIR). Aspirin-resistant subjects were significantly more likely to have a large ischemic focus (Odds Ratio (OR) = 45.00, 95% Confidence Interval (CI) = 1.49–135.36, p = 0.0285 for DWI; OR = 28.00, 95% CI = 1.35–58.59, p = 0.0312 for FLAIR) than aspirin-sensitive subjects with large-vessel disease. Conclusion: In patients with ischemic stroke due to large-vessel disease, high on-treatment platelet reactivity affects the extent of acute and chronic ischemic lesions.

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Collateral Recruitment Is Impaired by Cerebral Small Vessel Disease

Stroke ◽

10.1161/strokeaha.119.027661 ◽

2020 ◽

Vol 51 (5) ◽

pp. 1404-1410 ◽

Cited By ~ 3

Author(s):

Michelle P. Lin ◽

Thomas G. Brott ◽

David S. Liebeskind ◽

James F. Meschia ◽

Kevin Sam ◽

...

Keyword(s):

White Matter ◽

White Matter Hyperintensities ◽

Small Vessel Disease ◽

Cerebral Small Vessel Disease ◽

Cerebral Microbleeds ◽

Large Vessel ◽

Small Vessel ◽

Perivascular Spaces ◽

Vessel Disease ◽

Poor Recruitment

Background and Purpose— Cerebral small vessel disease (SVD) is associated with increased stroke risk and poor stroke outcomes. We aimed to evaluate whether chronic SVD burden is associated with poor recruitment of collaterals in large-vessel occlusive stroke. Methods— Consecutive patients with middle cerebral artery or internal carotid artery occlusion presenting within 6 hours after stroke symptom onset who underwent thrombectomy from 2012 to 2017 were included. The prespecified primary outcome was poor collateral flow, which was assessed on baseline computed tomographic angiography (poor, ≤50% filling; good, >50% filling). Markers of chronic SVD on brain magnetic resonance imaging were rated for the extent of white matter hyperintensities, enlarged perivascular spaces, chronic lacunar infarctions and cerebral microbleeds using the Standards for Reporting Vascular Changes on Neuroimaging criteria. Severity of SVD was quantified by adding the presence of each SVD feature, with a total possible score of 0 to 4; each SVD type was also evaluated separately. Multivariable logistic regression analyses were performed to evaluate the relationships between SVD and poor collaterals, with adjustment for potential confounders. Results— Of the 100 eligible patients, the mean age was 65±16 years, median National Institutes of Health Stroke Scale score was 15, and 68% had any SVD. Poor collaterals were observed in 46%, and those with SVD were more likely to have poor collaterals than patients without SVD (aOR, 1.9 [95% CI, 1.1–3.2]). Of the SVD types, poor collaterals were significantly associated with white matter hyperintensities (aOR, 2.9 per Fazekas increment [95% CI, 1.6–5.3]) but not with enlarged perivascular spaces (adjusted odds ratio [aOR], 1.3 [95% CI, 0.4–4.0]), lacunae (aOR, 2.1 [95% CI, 0.6–7.1]), or cerebral microbleeds (aOR, 2.1 [95% CI, 0.6–7.8]). Having a greater number of different SVD markers was associated with a higher odds of poor collaterals (crude trend P <0.001; adjusted P =0.056). There was a dose-dependent relationship between white matter hyperintensity burden and poor collaterals: adjusted odds of poor collaterals were 1.5, 3.0, and 9.7 across Fazekas scores of 1 to 3 ( P trend=0.015). No patient with an SVD score of 4 had good collaterals. Conclusions— Chronic cerebral SVD is associated with poor recruitment of collaterals in large vessel occlusive stroke. A prospective study to elucidate the potential mechanism of how SVD may impair the recruitment of collaterals is ongoing.

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Pre-micro RNA polymorphism detection in small versus large vessel disease in stroke patients

QJM ◽

10.1093/qjmed/hcaa054.015 ◽

2020 ◽

Vol 113 (Supplement_1) ◽

Author(s):

H H Elkhawas ◽

H H Afify ◽

H Shokri ◽

E Hassan ◽

A Alzahaby

Keyword(s):

Small Vessel Disease ◽

Susceptibility Gene ◽

Large Vessel ◽

Small Vessel ◽

Stroke Patients ◽

Functional Polymorphisms ◽

Vessel Disease ◽

Stroke Subtypes ◽

Micro Rnas ◽

Large Vessel Disease

Abstract Article Outline Abstract Introduction Patients and methods Procedure Statistical analysis Results Discussion Conclusion References Background Cerebrovascular accidents are the second leading cause of death and the third leading cause of disability worldwide. The methods currently available for diagnosis and prognosis of cerebral ischaemia still require further improvements. Micro-RNAs (small non-coding RNAs) have been recently reported as useful biomarkers in diseases such as cancer and diabetes. Further research concerned with microRNA (miRNA) profiling from peripheral blood to detect and identify characteristic patterns in ischaemic stroke is crucial. Aim of the work This study aims to investigate the association between three potentially functional polymorphisms in pre-miRNAs and stroke subtypes (small vessel disease and large vessel disease) in a sample of Egyptian stroke patients. Patients and Methods This is a cross sectional study conducted in Ain Shams University Hospitals in which 81 patients presenting with cerebrovascular stroke fulfilling criteria of small vessel disease (SVD) or large vessel disease (LVD) according to TOAST [2] classification in the period from March 2018 to August 2018 were included. Blood samples were withdrawn for DNA extraction to investigate the association between three potentially functional polymorphisms (rs2910164, rs11614913, and rs3746444) in pre-miRNAs (hsamiR-146a, hsa-miR-196a2, and hsa-miR-499, respectively). Results Smoking, hypertension and diabetes were significant value in both stroke subtypes. Meanwhile, age and gender showed no significance between both stroke subtypes. Conclusion Ischemic stroke has polygenic basis, but identification of stroke susceptibility gene and quantification of associated risks has been hindered by conflicting results from different studies.

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Abstract TP477: Vessel Diameter, Brain Perfusion and Small Vessel Disease Burden in HIV+ Population and Controls

Stroke ◽

10.1161/str.51.suppl_1.tp477 ◽

2020 ◽

Vol 51 (Suppl_1) ◽

Author(s):

Igor B Títoff ◽

Kyle Murray ◽

Xing Qiu ◽

Henry Wang ◽

Sanjay Maggirwar ◽

...

Keyword(s):

Multivariate Regression ◽

Small Vessel Disease ◽

Vessel Diameter ◽

Large Vessel ◽

Small Vessel ◽

Hiv Status ◽

Vessel Disease ◽

Volumetric Assessment ◽

The Relationship ◽

Extracranial Vessel

Cerebral small vessel disease (CSVD) in patients with HIV is a subject of ongoing study in regard to the effect of HIV infection on cerebral vessels. In our cohort of HIV+ (on stable cART for at least 12 weeks) and age-matched controls, we investigated the relationship between HIV status and extracranial large vessel diameter, burden of white matter hyperintensities (WMH), as well as cerebral blood flow (CBF). Subjects underwent MRI including an arterial spin labeling (ASL) sequence to calculate CBF and MRA to measure arterial diameters. Arterial diameter and regional CBF were used as outcome variables in multivariate regression models incorporating HIV status, hypertension, WMH burden, age, and Reynold score. Partial correlations were performed to assess the relationship strength between CBF and vessel diameter. Extracranial vessel diameter means were significantly different between HIV+ and HIV- cohorts after controlling for age, Reynold score, WMH, hypertension, and regional CBF means. CBF was not significantly different in the presence of HIV, nor WMH. However, hypertension and age were significantly associated with CBF in multivariate regression analysis. Extracranial vessel diameter and WMH were not significantly related. Accounting for HIV status did not affect this correlation. Extracranial large vessel diameter (0.3) and age (0.6) were strongly and significantly partially correlated with CBF. There appears to be a relationship between HIV status and caliber of extracranial vessels, suggesting possible effect of HIV on large vessel health. Vessel diameter and WMH may be related due to similar risk factors, however, further study is needed at this time. As expected, large vessel diameter correlated with perfusion metrics and age. Future directions include a volumetric assessment of WMH and assessments of the relationship between markers of platelets and endothelial dysfunction.

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