scholarly journals Langerhans Cell Histiocytosis of the Thyroid Leading to the Diagnosis of a Disseminated Form

2020 ◽  
Vol 2020 ◽  
pp. 1-3
Author(s):  
Ibtissem Ben Nacef ◽  
Sabrine Mekni ◽  
Chedi Mhedhebi ◽  
Ines Riahi ◽  
Imen Rojbi ◽  
...  
Keyword(s):  
Thyroid Gland ◽  
Thyroid Nodule ◽  
Langerhans Cells ◽  
Langerhans Cell Histiocytosis ◽  
Histological Study ◽  
S100 Protein ◽  
Langerhans Cell ◽  
Multisystemic Disease ◽  
Right Lobe ◽  
The Right

Langerhans cell histiocytosis (LCH) is a rare sporadic proliferative disorder of Langerhans cells. LCH rarely involves the thyroid gland. We report herein a case of a disseminated chronic form of LCH with a diagnosis established by histological examination of the thyroid gland. It is about a 37-year-old female who underwent total thyroidectomy for a thyroid nodule of the right lobe. Histological study showed a granulomatous thyroiditis, and the immunohistochemistry study revealed a strong positivity of histiocytes for the CD1 antigen and for the S100 protein. The incidence of LCH involving the thyroid gland, either as an isolated lesion or as a part of multisystemic disease, is extremely rare.

scholarly journals Isolated Langerhans Cell Histiocytosis of the Thyroid in an Adult Female: One-Year Followup

2011 ◽  
Vol 2011 ◽  
pp. 1-4 ◽  
Author(s):  
Ramon Vilallonga ◽  
Andrea Ciudin ◽  
José Manuel Fort ◽  
Juan Antonio Baena ◽  
Oscar Gonzalez ◽  
...  
Keyword(s):  
Thyroid Gland ◽  
Langerhans Cell Histiocytosis ◽  
Immunohistochemical Analysis ◽  
Needle Aspiration ◽  
Langerhans Cell ◽  
Thyroid Mass ◽  
Histologic Evaluation ◽  
One Year ◽  
The Right ◽  
Surgery Department

Thyroid gland involvement as the unique presentation of Langerhans cell histiocytosis is a rare phenomenon that can result in misdiagnosis. We report a case of Langerhans cell histiocytosis (LCH) presenting as a thyroid mass. It is a 52-year-old woman who presented an enlarged, diffusely firm, nontender, nonmobile, and not particularly nodular thyroid gland with mild compressive symptoms. Ultrasound and fine-needle aspiration showed a unique right node with benign signs. Patient was referred to our Ambulatory Surgery Department, where a hemithyroidectomy was performed. Histologic evaluation of the right thyroid gland revealed an involvement by LCH, confirmed by immunohistochemical analysis showing Langerhans cells that were positive for CD1a. LCH was a completely incidental occult finding apparent only after surgical resection and examination of the gland. Patient was evaluated, and no evidence of systemic affectation was found. LCH can rarely involve the thyroid gland in adults. Few cases have been reported in the literature. Most patients had evidence of LCH involving other anatomic sites.

scholarly journals Langerhans Cell Histiocytosis: a Case Report

2013 ◽  
Vol 5 (2) ◽  
pp. 74-86
Author(s):  
Mirjana Paravina ◽  
Dragan Jovanović ◽  
Milenko Stanojević ◽  
Ljiljana Nikolić
Keyword(s):  
Langerhans Cells ◽  
Langerhans Cell Histiocytosis ◽  
Early Stage ◽  
Fatal Outcome ◽  
Langerhans Cell ◽  
Neoplastic Disease ◽  
Multisystem Disease ◽  
Organ Systems ◽  
The Right

Abstract Langerhans cell histiocytosis is a disease which results from accumulation or proliferation of a clonal population of cells with the phenotype of Langerhans cells arrested at an early stage of activation that are functionally deficient. The etiology and pathogenesis of the disorder are still unknown. There are ongoing investigations to determine whether it is a reactive or a neoplastic disease. The fact is that neoplastic and reactive processes may have many clinical and pathological similarities. Some emphasize the role of “cytokine storm” in Langerhans cells. Further studies are necessary in all areas, from the etiology and pathogenesis to diagnosis and therapy. Langerhans cell histiocytosis primarily affects bones, but less commonly it may involve other organ systems, or present as a multisystem disease. The clinical course is variable, from benign forms with spontaneous resolution, to chronic disseminated forms with fatal outcome. This is a report of a 29-year-old man with Langerhans cell histiocytosis with an onset at the age of 8, which later progressed to a multisystem disease. Apart from lesions on the skin and exposed mucous membranes, the patient also presented with: diabetes insipidus, granuloma of the right femur and slight bulbar protrusion of the right eye. The patient experienced spontaneous pneumothorax on two occasions. The diagnosis of Langerhans cell histiocytosis was histologically confirmed using electron microscopy by presence of Birbeck granules in the histiocytes. A favorable therapeutic response was obtained after systemic corticosteroid therapy.

scholarly journals Multisystem Langerhans cell histiocytosis coexisting with metastasizing adenocarcinoma of the lung: A case report

2013 ◽  
Vol 70 (12) ◽  
pp. 1159-1161
Author(s):  
Aleksandra Lovrenski ◽  
Mirna Djuric ◽  
Istvan Klem ◽  
Zivka Eri ◽  
Milana Panjkovic ◽  
...  
Keyword(s):  
Case Report ◽  
Lung Adenocarcinoma ◽  
Langerhans Cells ◽  
Langerhans Cell Histiocytosis ◽  
Incidental Finding ◽  
Lung Parenchyma ◽  
Langerhans Cell ◽  
Heavy Smoker ◽  
Unknown Etiology ◽  
The Right

Introduction. Langerhans cell histiocytosis (LCH) is an uncommon disease of unknown etiology characterized by uncontrolled proliferation and infiltration of various organs by Langerhans cells. Case report. We presented a 54-year-old man, heavy smoker, with dyspnea, cough, hemoptysis, headache and ataxia, who died shortly after admission to our hospital. On the autopsy, tumor was found in the posterior segment of the right upper pulmonary lobe as well as a right-sided occipitoparietal lesion which penetrated into the right ventricle resulting in internal and external hematocephalus. Histologically and immunohistohemically, the diagnosis of primary lung adenocarcinoma with brain metastasis was made (tumor cells showed positivity for CK7 and TTF-1 which confirmed the diagnosis). In the lung parenchyma around the tumor, as well as in brain tissue around the metastatic adenocarcinoma histiocytic lesions were found. Light microscopic examination of the other organs also showed histiocytic lesions involving the pituitary gland, hypothalamus, spleen and mediastinal lymph nodes. Immunohistochemical studies revealed CD68, S-100 and CD1a immunoreactivity within the histiocytes upon which the diagnosis of Langerhans' cells histiocytosis was made. Conclusion. The multisystem form of LCH with extensive organ involvement was an incidental finding, while metastatic lung adenocarcinoma to the brain that led to hematocephalus was the cause of death.

Acute thyroiditis after tooth extraction

1935 ◽  
Vol 31 (3-4) ◽  
pp. 535-535
Author(s):  
E. Auslender
Keyword(s):  
Thyroid Gland ◽  
Tooth Extraction ◽  
Acute Inflammation ◽  
Right Lobe ◽  
The Right ◽  
Acute Thyroiditis

Five days after tooth extraction, a 24-year-old woman developed acute inflammation of the right lobe of the thyroid gland, which after a while spontaneously healed.

Rectal carcinoma metastatic to the thyroid gland

1996 ◽  
Vol 110 (2) ◽  
pp. 192-195 ◽  
Author(s):  
Thomas W. Mesko ◽  
Julie Friedman ◽  
Harry Sendzischew ◽  
Daniel D. Nixon
Keyword(s):  
Thyroid Gland ◽  
Rectal Carcinoma ◽  
Secondary Malignancy ◽  
Prior History ◽  
Low Back ◽  
Metastatic Adenocarcinoma ◽  
History Of ◽  
Right Lobe ◽  
The Right ◽  
History Of Cancer

AbstractClinically evident metastases to the thyroid gland are rarely found antemortem. A case of a 59-year-old woman with a history of rectal carcinoma, who presented with low back pain and a mass in the right lobe of her thyroid gland, is presented. The tumour of the thyroid was found to be metastatic adenocarcinoma from her previous rectal cancer. Other synchronous metastases were noted in her lumbar spine and kidneys.The clinical finding of metastases to the thyroid gland is rare, particularly from a colorectal primary. One must consider, however, the possibility of a tumour of the thyroid gland representing a secondary malignancy in any patient with a prior history of cancer.

Clonal proliferation of Langerhans cells in Langerhans cell histiocytosis

The Lancet ◽  
1994 ◽  
Vol 343 (8900) ◽  
pp. 767-768 ◽  
Author(s):  
R.C. Yu ◽  
A.C. Chu ◽  
C. Chu ◽  
L. Buluwela
Keyword(s):  
Langerhans Cells ◽  
Langerhans Cell Histiocytosis ◽  
Langerhans Cell ◽  
Clonal Proliferation

scholarly journals Ultrasonographic and Scintigraphic Findings of Thyroid Hemiagenesis in a Child: Report of a Rare Male Case

2015 ◽  
Vol 2015 ◽  
pp. 1-3
Author(s):  
Ümit Yaşar Ayaz ◽  
Sevin Ayaz ◽  
Mehmet Ercüment Döğen ◽  
Arman Api
Keyword(s):  
Thyroid Gland ◽  
Thyroid Tissue ◽  
Invasive Procedure ◽  
Final Diagnosis ◽  
Left Lobe ◽  
Current Status ◽  
Complementary Method ◽  
Thyroid Hemiagenesis ◽  
Right Lobe ◽  
The Right

Thyroid hemiagenesis is a rare congenital anomaly in which one lobe of thyroid gland fails to develop. It is much rarer in males. There is a higher incidence of associated thyroid disorders in patients with thyroid hemiagenesis; therefore early and prompt diagnosis is important for children. We present the ultrasonographic and scintigraphic findings of thyroid hemiagenesis in an eight-year-old-boy. On ultrasonography (US), left lobe of the thyroid gland could not be demonstrated and the right lobe showed minimal hyperplasia. Its echogenicity was normal and no nodule was seen. On thyroid scintigraphy, left lobe of thyroid gland or any ectopic thyroid tissue could not be demonstrated, while the right lobe showed minimal hyperplasia. Without performing any invasive procedure, we enrolled the child in a follow-up program with the guidance of US and scintigraphy, which were effective both in making the final diagnosis of thyroid hemiagenesis and in evaluating the current status of the present thyroid tissue. In conclusion, if only one thyroid lobe is detected in a pediatric case initially with US or scintigraphy, the diagnosis of thyroid hemiagenesis should be suggested and, before any unnecessary or invasive attempt, the other complementary method (scintigraphy/US) should be performed.

scholarly journals THE HISTOLOGICAL CHANGES IN THE THYROID GLAND OF THE RABBIT FOLLOWING LOBECTOMY

1925 ◽  
Vol 42 (2) ◽  
pp. 193-200 ◽  
Author(s):  
J. Hamilton Crawford ◽  
J. N. J. Hartley
Keyword(s):  
Thyroid Gland ◽  
Epithelial Cells ◽  
Left Lobe ◽  
Compensatory Hypertrophy ◽  
The Other ◽  
Histological Changes ◽  
Right Lobe ◽  
Cervical Sympathetic ◽  
The Right

1. In a series of rabbits the changes which took place in the histology of the left lobe of the thyroid gland after excision of the right lobe have been studied at varied intervals of time. 2 days after the removal of one lobe the other lobe showed a slightly increased colloid content, an increased vacuolation of the colloid, and a slight increase in the size of the epithelial cells. At the end of a week the vesicles were greatly increased in size, distended with colloid, and the epithelial cells were flattened, while after 3 to 4 months signs of compensatory hypertrophy were present. 2. The changes observed were uninfluenced by division of the vagus or cervical sympathetic.

scholarly journals Nonbacterial Osteitis of the Clavicle: Longitudinal Imaging Series from Initial Diagnosis to Clinical Improvement

2015 ◽  
Vol 2015 ◽  
pp. 1-4
Author(s):  
E. Roos ◽  
M. Maas ◽  
S. J. M. Breugem ◽  
G. R. Schaap ◽  
J. A. M. Bramer
Keyword(s):  
Case Report ◽  
Clinical Improvement ◽  
Langerhans Cell Histiocytosis ◽  
Autoinflammatory Disease ◽  
Langerhans Cell ◽  
Differential Diagnoses ◽  
Longitudinal Imaging ◽  
The Right ◽  
Established Treatment

Nonbacterial osteitis is a rare autoinflammatory disease. Often it is mistaken for a tumor or osteomyelitis. We present a case of a twelve-year-old girl referred to our hospital because of a lesion of the right clavicle. The differential diagnoses were sarcoma, osteitis, and Langerhans cell histiocytosis. After biopsy the diagnosis nonbacterial osteitis (NBO) was established. Treatment of choice is a nonsteroidal anti-inflammatory drug. This case report gives a complete follow-up of the disease, showing the pitfalls of the diagnosis.

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