scholarly journals Isolated Langerhans Cell Histiocytosis of the Thyroid in an Adult Female: One-Year Followup

2011 ◽  
Vol 2011 ◽  
pp. 1-4 ◽  
Author(s):  
Ramon Vilallonga ◽  
Andrea Ciudin ◽  
José Manuel Fort ◽  
Juan Antonio Baena ◽  
Oscar Gonzalez ◽  
...  
Keyword(s):  
Thyroid Gland ◽  
Langerhans Cell Histiocytosis ◽  
Immunohistochemical Analysis ◽  
Needle Aspiration ◽  
Langerhans Cell ◽  
Thyroid Mass ◽  
Histologic Evaluation ◽  
One Year ◽  
The Right ◽  
Surgery Department

Thyroid gland involvement as the unique presentation of Langerhans cell histiocytosis is a rare phenomenon that can result in misdiagnosis. We report a case of Langerhans cell histiocytosis (LCH) presenting as a thyroid mass. It is a 52-year-old woman who presented an enlarged, diffusely firm, nontender, nonmobile, and not particularly nodular thyroid gland with mild compressive symptoms. Ultrasound and fine-needle aspiration showed a unique right node with benign signs. Patient was referred to our Ambulatory Surgery Department, where a hemithyroidectomy was performed. Histologic evaluation of the right thyroid gland revealed an involvement by LCH, confirmed by immunohistochemical analysis showing Langerhans cells that were positive for CD1a. LCH was a completely incidental occult finding apparent only after surgical resection and examination of the gland. Patient was evaluated, and no evidence of systemic affectation was found. LCH can rarely involve the thyroid gland in adults. Few cases have been reported in the literature. Most patients had evidence of LCH involving other anatomic sites.

scholarly journals Langerhans Cell Histiocytosis of the Thyroid Leading to the Diagnosis of a Disseminated Form

2020 ◽  
Vol 2020 ◽  
pp. 1-3
Author(s):  
Ibtissem Ben Nacef ◽  
Sabrine Mekni ◽  
Chedi Mhedhebi ◽  
Ines Riahi ◽  
Imen Rojbi ◽  
...  
Keyword(s):  
Thyroid Gland ◽  
Thyroid Nodule ◽  
Langerhans Cells ◽  
Langerhans Cell Histiocytosis ◽  
Histological Study ◽  
S100 Protein ◽  
Langerhans Cell ◽  
Multisystemic Disease ◽  
Right Lobe ◽  
The Right

Langerhans cell histiocytosis (LCH) is a rare sporadic proliferative disorder of Langerhans cells. LCH rarely involves the thyroid gland. We report herein a case of a disseminated chronic form of LCH with a diagnosis established by histological examination of the thyroid gland. It is about a 37-year-old female who underwent total thyroidectomy for a thyroid nodule of the right lobe. Histological study showed a granulomatous thyroiditis, and the immunohistochemistry study revealed a strong positivity of histiocytes for the CD1 antigen and for the S100 protein. The incidence of LCH involving the thyroid gland, either as an isolated lesion or as a part of multisystemic disease, is extremely rare.

scholarly journals Langerhan’s cell histiocytosis with oral manifestation in a 3-year-old child: a case report

2021 ◽  
Vol 10 (5) ◽  
pp. e40310515136
Author(s):  
Joana Leticia Vendruscolo ◽  
Bruna da Fonseca Wastner ◽  
Cleverson Patussi ◽  
Sergio Ossamu Ioshii ◽  
Juliana Lucena Schussel ◽  
...  
Keyword(s):  
Langerhans Cell Histiocytosis ◽  
Soft Tissues ◽  
Osteolytic Lesion ◽  
Immunohistochemical Analysis ◽  
Langerhans Cell ◽  
Submandibular Region ◽  
Oral Manifestation ◽  
S 100 ◽  
The Right ◽  
Single Lesion

Langerhans cell histiocytosis (LCH) is a disorder that may affect the bones, skin, liver, lung, and hematopoietic and neuroendocrine systems. This condition may manifest as a single lesion, multiple lesions, or as a disseminated and potentially fatal disease. We aim to report a case of a 3-year-old child with LCH in the mandible, sharing with the readers the challenging process of this diagnosis. A three-year-old male patient with persistent swelling in the right submandibular region was referred to the Department of Pediatrics of the Erasto Gaertner Hospital for an evaluation. Initial physical exam revealed a diffuse flaccid swelling occupying the entire right mandibular ramus, from the angle to the preauricular region and CT scan showed an osteolytic lesion with erosion of the internal and external cortices of the mandible and an extension to soft tissues that displaced the masseter muscle. Immunohistochemical analysis confirmed the diagnosis of Langerhans cell histiocytosis through positive tests for CD1a, CD68, S-100, and Vimentin. The treatment proposed was a combination of Vinblastine 6 mg/m3 for 6 weeks and Prednisone 40mg for 4 weeks.The differential diagnosis included pathologies such as rhabdomyosarcoma, Ewing's sarcoma, and, less likely, osteosarcoma and central giant cell granuloma.

Langerhans' cell histiocytosis – A rare cause of sudden onset unilateral sensorineural hearing loss

1999 ◽  
Vol 113 (12) ◽  
pp. 1098-1100 ◽  
Author(s):  
I. Hore ◽  
R. B. Mitchell ◽  
G. Radcliffe ◽  
R. Quiney ◽  
T. Walker
Keyword(s):  
Hearing Loss ◽  
Sensorineural Hearing Loss ◽  
Langerhans Cell Histiocytosis ◽  
External Beam Radiotherapy ◽  
Sudden Onset ◽  
Langerhans Cell ◽  
Sensorineural Hearing ◽  
Magnetic Resonance Imaging Mri ◽  
One Year ◽  
The Right

AbstractLangerhans' cell histiocytosis is a rare disorder of unknown aetiology in which pathological Langerhans' cells accumulate and destroy local tissue. We report a 38-year-old female who presented with a sudden onset of left sensormeural hearing loss. Magnetic resonance imaging (MRI) revealed a contrast-enhancing lesion in the left mastoid and a second lesion in the hypothalamus. Following left mastoid exploration and biopsy a definitive diagnosis of Langerhans' cell histiocytosis was made and the patient was treated with external beam radiotherapy. Subsequent right femur and right mastoid involvement were successfully treated with steroids and cytotoxic chemotherapy. At one year follow-up the patient had residual left-sided sensorineural hearing loss with normal hearing in the right ear. To our knowledge, Langerhans' cell histiocytosis has not been previously reported as a cause of unilateral sudden onset sensorineural hearing loss. It should be considered in the differential diagnosis of this condition.

Cytological Diagnostic Approach in 3 Cases of Langerhans Cell Histiocytosis Presenting Primarily as a Thyroid Mass

2015 ◽  
Vol 59 (5) ◽  
pp. 418-424 ◽  
Author(s):  
Nikita Oza ◽  
Kintan Sanghvi ◽  
Santosh Menon ◽  
Vinita Pant ◽  
Meenal Patil ◽  
...  
Keyword(s):  
Langerhans Cell Histiocytosis ◽  
Plasma Cells ◽  
Clinical Course ◽  
Paediatric Population ◽  
Needle Aspiration ◽  
Langerhans Cell ◽  
Aspiration Cytology ◽  
Thyroid Mass ◽  
Needle Aspiration Cytology ◽  
Overall Mortality

Background: Langerhans cell histiocytosis (LCH) is a monoclonal disease of specialised histiocytes characterised by the proliferation of neoplastic Langerhans cells (LCs) with a varying admixture of mature lymphocytes, eosinophils and plasma cells. LCH commonly occurs in the paediatric population and young adults with the involvement of bone, skin and lymph nodes. LCH has a protracted clinical course with an overall mortality rate of 3%. Primary involvement of the thyroid gland in LCH at presentation is a rare phenomenon that can result in misdiagnosis with consequent mismanagement. Case: Ultrasound-guided fine-needle aspiration cytology (FNAC) of the thyroid was performed in 3 cases at a tertiary cancer centre, including 2 referral cases where the patient presented with the only symptom of progressive thyroid enlargement. These cases were reported initially or on review and the results were correlated with histology/ancillary techniques. A cytological diagnosis of suspicion for LCH was offered in 2 cases at our centre and 1 case was referred to our centre with a diagnosis of suspected papillary thyroid carcinoma. On review of outside smears at our centre, the diagnosis was changed to suspected LCH. The diagnosis was confirmed by immunopositivity for CD68, CD1a and S100 in 1 case and Tru-cut biopsy followed by immunohistochemistry for CD1a, S100, TTF-1 and LCA in the other 2 cases. Conclusion: FNAC was helpful in accurately diagnosing LCH even though the presentation was unusual. Thus, unnecessary surgery was obviated.

scholarly journals Fine-Needle Aspiration Biopsy of Langerhans Cell Histiocytosis of Thyroid Gland

2015 ◽  
Vol 100 (1) ◽  
pp. 15-16 ◽  
Author(s):  
Jutarat Sangtian ◽  
Tanawan Riangwiwat ◽  
Siripich Triamchaisri ◽  
Wasana Kanoksil ◽  
Chutintorn Sriphrapradang
Keyword(s):  
Thyroid Gland ◽  
Fine Needle Aspiration ◽  
Langerhans Cell Histiocytosis ◽  
Fine Needle Aspiration Biopsy ◽  
Needle Aspiration ◽  
Langerhans Cell ◽  
Aspiration Biopsy ◽  
Fine Needle ◽  
Needle Aspiration Biopsy

Electrochemotherapy with intra-tumoral cisplatin for the treatment of fibrosarcoma in a horse

2018 ◽  
Author(s):  
M. Bharathidasan ◽  
B. Justin William ◽  
Ravi Sundar George Sundar George ◽  
A. Arunprasad ◽  
R. Sivasankar
Keyword(s):  
Complete Response ◽  
Tumour Volume ◽  
Needle Aspiration ◽  
Medial Aspect ◽  
History Of ◽  
Subcutaneous Tissues ◽  
Needle Aspiration Cytology ◽  
One Year ◽  
The Right

A two years old Kathiawar stallion was reported with the history of two, pedunculated hard mass medially on the thigh and hock of the right hind limb, progressively increasing for the past two months. Fine needle aspiration cytology revealed fibrosarcoma.The tumour on the medial aspect of the thigh was injected with cisplatin intra-tumorally at a dose rate of 0.3 mg/cm3 of tumour volume and was exposed to ECT. The tumour on the medial aspect of the hock was excised incompletely to preserve skin and subcutaneous tissues around the tumour for wound opposition and treated with intra-tumoral injection of cisplatin followed by ECT. Following electrochemotherapy complete response was noticed onthe 3rd and 4th week for the tumours on the thigh and hock respectively. No recurrence was noticed during the follow-up period of one year revealing ETC with cisplatin as a single treatment and also in combination with surgery is effective for the treatment of fibrosarcoma in equines.

scholarly journals FNAC of Bacillus- Calmette- Guerin lymphadenitis masquerading as Langerhans cell histiocytosis

CytoJournal ◽  
2004 ◽  
Vol 1 ◽  
pp. 6 ◽  
Author(s):  
Nalini Gupta ◽  
Vijay Kumar ◽  
Raje Nijhawan ◽  
Radhika Srinivasan ◽  
Arvind Rajwanshi
Keyword(s):  
Langerhans Cell Histiocytosis ◽  
Index Case ◽  
Needle Aspiration ◽  
Langerhans Cell ◽  
Bacillus Calmette Guerin ◽  
Diagnostic Challenge ◽  
Aspiration Cytology ◽  
Needle Aspiration Cytology ◽  
Generalized Lymphadenopathy ◽  
Foamy Macrophages

Bacillus Calmette Guerin (BCG) lymphadenitis is a well known entity. Disseminated BCG infection usually presents as generalized lymphadenopathy, skin rash and hepatosplenomegaly and at times, can pose a diagnostic challenge to clinicians. There are only a few published studies on the cytological findings of BCG lymphadenitis. In this letter we report the fine needle aspiration cytology (FNAC) of BCG lymphadenitis clinically masquerading as Langerhans cell histiocytosis (LCH). FNA smears showed sheets of foamy macrophages and many polymorphs in a dirty necrotic background with many macrophages as well as polymorphs showing negatively stained rod like structures within their cytoplasm. Zeihl Neelson stain revealed that these cells were heavily loaded with acid fast bacilli (AFB). In the index case, AFB were also seen within the cytoplasm of polymorphs, which has not been documented earlier in the literature.

scholarly journals Nonbacterial Osteitis of the Clavicle: Longitudinal Imaging Series from Initial Diagnosis to Clinical Improvement

2015 ◽  
Vol 2015 ◽  
pp. 1-4
Author(s):  
E. Roos ◽  
M. Maas ◽  
S. J. M. Breugem ◽  
G. R. Schaap ◽  
J. A. M. Bramer
Keyword(s):  
Case Report ◽  
Clinical Improvement ◽  
Langerhans Cell Histiocytosis ◽  
Autoinflammatory Disease ◽  
Langerhans Cell ◽  
Differential Diagnoses ◽  
Longitudinal Imaging ◽  
The Right ◽  
Established Treatment

Nonbacterial osteitis is a rare autoinflammatory disease. Often it is mistaken for a tumor or osteomyelitis. We present a case of a twelve-year-old girl referred to our hospital because of a lesion of the right clavicle. The differential diagnoses were sarcoma, osteitis, and Langerhans cell histiocytosis. After biopsy the diagnosis nonbacterial osteitis (NBO) was established. Treatment of choice is a nonsteroidal anti-inflammatory drug. This case report gives a complete follow-up of the disease, showing the pitfalls of the diagnosis.

Fine Needle Aspiration of Langerhans Cell Histiocytosis of the Lymph Nodes

2002 ◽  
Vol 46 (4) ◽  
pp. 753-756 ◽  
Author(s):  
Perikala V. Kumar ◽  
Abdullah Mousavi ◽  
Mehran Karimi ◽  
Gholam Reza Bedayat
Keyword(s):  
Lymph Nodes ◽  
Fine Needle Aspiration ◽  
Langerhans Cell Histiocytosis ◽  
Needle Aspiration ◽  
Langerhans Cell ◽  
Fine Needle
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