Background:
Metabolomics has gained importance in clinical applications over the last decade. Metabolomics
studies are significant because the systemic metabolome is directly affected by disease conditions. Metabolome-based
biomarkers are actively being developed for early diagnosis and to indicate the stage of specific diseases. Additionally,
understanding the effect of an intervention on a living organism at the molecular level is a crucial strategy for
understanding novel or unexpected biological processes.
Results:
The simultaneous improvements in advanced analytical techniques, sample preparation techniques, computer
technology, and databank contents has enabled more valuable scientific information to be gained from metabolomics than
ever before. With over 15,000 known endogenous metabolites, there is no single analytical technique capable of analyzing
the whole metabolome. However, capillary electrophoresis-mass spectrometry (CE-MS) is a unique technique used to
analyze an important portion of metabolites not accessible by liquid chromatography or gas chromatography techniques.
The analytical capability of CE, combined with recent sample preparation techniques focused on extracting polar-ionic
compounds, make CE-MS a perfect technique for metabolomic studies.
Conclusion:
Here, previous reviews of CE-MS based metabolomics are evaluated to highlight recent improvements in
this technique. Specifically, we review papers from the last two years (2018 and 2019) on CE-MS based metabolomics.
The current situation and the challenges facing metabolomic studies are discussed to reveal the high potential of CE-MS
for further studies, especially in biomarker development studies.
Activation of Leukopoiesis in Rat Blood with Trimecaine-Based Ionic Compounds
