The Application of Mechanical Stimulations in Tendon Tissue Engineering

Tendon injury is the most common disease in the musculoskeletal system. The current treatment methods have many limitations, such as poor therapeutic effects, functional loss of donor site, and immune rejection. Tendon tissue engineering provides a new treatment strategy for tendon repair and regeneration. In this review, we made a retrospective analysis of applying mechanical stimulation in tendon tissue engineering, and its potential as a direction of development for future clinical treatment strategies. For this purpose, the following topics are discussed; (1) the context of tendon tissue engineering and mechanical stimulation; (2) the applications of various mechanical stimulations in tendon tissue engineering, as well as their inherent mechanisms; (3) the application of magnetic force and the synergy of mechanical and biochemical stimulation. With this, we aim at clarifying some of the main questions that currently exist in the field of tendon tissue engineering and consequently gain new knowledge that may help in the development of future clinical application of tissue engineering in tendon injury.

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The Role of Scaffolds in Tendon Tissue Engineering

Journal of Functional Biomaterials ◽

10.3390/jfb11040078 ◽

2020 ◽

Vol 11 (4) ◽

pp. 78

Author(s):

Angelo V. Vasiliadis ◽

Konstantinos Katakalos

Keyword(s):

Tissue Engineering ◽

Tendon Repair ◽

Treatment Strategies ◽

Tendon Injury ◽

Functional Restoration ◽

Tendon Tissue ◽

Age Related ◽

Tendon Tissue Engineering ◽

Promising Solution

Tendons are unique forms of connective tissue aiming to transmit the mechanical force of muscle contraction to the bones. Tendon injury may be due to direct trauma or might be secondary to overuse injury and age-related degeneration, leading to inflammation, weakening and subsequent rupture. Current traditional treatment strategies focus on pain relief, reduction of the inflammation and functional restoration. Tendon repair surgery can be performed in people with tendon injuries to restore the tendon’s function, with re-rupture being the main potential complication. Novel therapeutic approaches that address the underlying pathology of the disease is warranted. Scaffolds represent a promising solution to the challenges associated with tendon tissue engineering. The ideal scaffold for tendon tissue engineering needs to exhibit physiologically relevant mechanical properties and to facilitate functional graft integration by promoting the regeneration of the native tissue.

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Application of Different Biomaterials in Achilles Tendon Repair for Exercise Injury

Advanced Materials Research ◽

10.4028/www.scientific.net/amr.886.329 ◽

2014 ◽

Vol 886 ◽

pp. 329-332

Author(s):

Na Zhao ◽

Wen Chen ◽

Tao Yan

Keyword(s):

Tissue Engineering ◽

Achilles Tendon ◽

Tendon Repair ◽

Functional Differentiation ◽

Tendon Injury ◽

Self Healing ◽

Advantages And Disadvantages ◽

Tendon Tissue Engineering ◽

Tendon Transplantation ◽

Scaffold Materials

The rupture of Achilles tendon is hard to self-healing and repair and it is easily left pain and dysfunction. For a long time, the treatment of Achilles tendon defect by many scholars conducted a lot of research, from the tendon autograft, allograft tendon transplantation to the artificial tendon transplantation, tissue engineering tendon transplantation. Practice has proved that these methods have their own advantages and disadvantages. Although the research and application of scaffold materials for tendon tissue engineering has achieved some success, but the application materials or the presence of biocompatibility, degradation problems or have poor mechanical properties, machining molding defects, there is still a big gap between the ideal scaffold materials. This study evaluated the different biological materials in the repair of Achilles tendon injury in effect, provide a theoretical reference for the key to construct tissue engineered tendon is to find appropriate scaffold materials for tendon cell adhesion, growth and functional differentiation.

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