The Role of Scaffolds in Tendon Tissue Engineering

Tendons are unique forms of connective tissue aiming to transmit the mechanical force of muscle contraction to the bones. Tendon injury may be due to direct trauma or might be secondary to overuse injury and age-related degeneration, leading to inflammation, weakening and subsequent rupture. Current traditional treatment strategies focus on pain relief, reduction of the inflammation and functional restoration. Tendon repair surgery can be performed in people with tendon injuries to restore the tendon’s function, with re-rupture being the main potential complication. Novel therapeutic approaches that address the underlying pathology of the disease is warranted. Scaffolds represent a promising solution to the challenges associated with tendon tissue engineering. The ideal scaffold for tendon tissue engineering needs to exhibit physiologically relevant mechanical properties and to facilitate functional graft integration by promoting the regeneration of the native tissue.

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The Application of Mechanical Stimulations in Tendon Tissue Engineering

Stem Cells International ◽

10.1155/2020/8824783 ◽

2020 ◽

Vol 2020 ◽

pp. 1-14

Author(s):

Renwang Sheng ◽

Yujie Jiang ◽

Ludvig J. Backman ◽

Wei Zhang ◽

Jialin Chen

Keyword(s):

Tissue Engineering ◽

Mechanical Stimulation ◽

Donor Site ◽

Tendon Repair ◽

Treatment Strategies ◽

Tendon Injury ◽

Common Disease ◽

Therapeutic Effects ◽

Tendon Tissue ◽

Tendon Tissue Engineering

Tendon injury is the most common disease in the musculoskeletal system. The current treatment methods have many limitations, such as poor therapeutic effects, functional loss of donor site, and immune rejection. Tendon tissue engineering provides a new treatment strategy for tendon repair and regeneration. In this review, we made a retrospective analysis of applying mechanical stimulation in tendon tissue engineering, and its potential as a direction of development for future clinical treatment strategies. For this purpose, the following topics are discussed; (1) the context of tendon tissue engineering and mechanical stimulation; (2) the applications of various mechanical stimulations in tendon tissue engineering, as well as their inherent mechanisms; (3) the application of magnetic force and the synergy of mechanical and biochemical stimulation. With this, we aim at clarifying some of the main questions that currently exist in the field of tendon tissue engineering and consequently gain new knowledge that may help in the development of future clinical application of tissue engineering in tendon injury.

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Application of Different Biomaterials in Achilles Tendon Repair for Exercise Injury

Advanced Materials Research ◽

10.4028/www.scientific.net/amr.886.329 ◽

2014 ◽

Vol 886 ◽

pp. 329-332

Author(s):

Na Zhao ◽

Wen Chen ◽

Tao Yan

Keyword(s):

Tissue Engineering ◽

Achilles Tendon ◽

Tendon Repair ◽

Functional Differentiation ◽

Tendon Injury ◽

Self Healing ◽

Advantages And Disadvantages ◽

Tendon Tissue Engineering ◽

Tendon Transplantation ◽

Scaffold Materials

The rupture of Achilles tendon is hard to self-healing and repair and it is easily left pain and dysfunction. For a long time, the treatment of Achilles tendon defect by many scholars conducted a lot of research, from the tendon autograft, allograft tendon transplantation to the artificial tendon transplantation, tissue engineering tendon transplantation. Practice has proved that these methods have their own advantages and disadvantages. Although the research and application of scaffold materials for tendon tissue engineering has achieved some success, but the application materials or the presence of biocompatibility, degradation problems or have poor mechanical properties, machining molding defects, there is still a big gap between the ideal scaffold materials. This study evaluated the different biological materials in the repair of Achilles tendon injury in effect, provide a theoretical reference for the key to construct tissue engineered tendon is to find appropriate scaffold materials for tendon cell adhesion, growth and functional differentiation.

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The Role of Bioreactors in Ligament and Tendon Tissue Engineering

Current Stem Cell Research & Therapy ◽

10.2174/1574888x10666150904113827 ◽

2016 ◽

Vol 11 (1) ◽

pp. 35-40 ◽

Cited By ~ 7

Author(s):

James Mace ◽

Andy Wheelton ◽

Wasim S. Khan ◽

Sanj Anand

Keyword(s):

Tissue Engineering ◽

Tendon Tissue ◽

Tendon Tissue Engineering

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Tissue engineering approaches for the construction of a completely autologous tendon substitute

Indian Journal of Plastic Surgery ◽

10.1055/s-0039-1699225 ◽

2008 ◽

Vol 41 (01) ◽

pp. 38-46

Author(s):

Bassetto Franco ◽

Vindigni Vincenzo ◽

Dalla Vedova Alessandro ◽

Carolin Tonello ◽

Giovanni Abatangelo ◽

...

Keyword(s):

Tissue Engineering ◽

In Vitro Regeneration ◽

Mechanical Stimuli ◽

Tendon Tissue ◽

Tendon Tissue Engineering ◽

Mammalian Tissues ◽

Fundamental Understanding ◽

In Vitro Preservation

ABSTRACTTissue engineering is a multidisciplinary field that involves the application of the principles and methods of engineering and life sciences towards i) the fundamental understanding of structure-function relationships in normal and pathological mammalian tissues and ii) the development of biological substitutes that restore, maintain or improve tissue function. The goal of tissue engineering is to surpass the limitations of conventional treatments based on organ transplantation and biomaterial implantation. The field of tendon tissue engineering is relatively unexplored due to the difficulty in in vitro preservation of tenocyte phenotype. Only recently has mechanobiology allowed us to gain a better understanding of the fundamental role of in vitro mechanical stimuli in maintaining the phenotype of tendinous tissue. This review analyzes the techniques used so far for in vitro regeneration of tendinous tissue.

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