scholarly journals Preventive Effect of Albumin Nano TPA Gene Plasmid Ultrasound Microbubble Carrier System on Thrombosis after Cardiac Valve Replacement

2020 ◽  
Vol 2020 ◽  
pp. 1-8
Author(s):  
Feng Qi ◽  
Linlin Zhao ◽  
Guohua Cai ◽  
Zhendong Sun ◽  
Naishi Wu
Keyword(s):  
Valve Replacement ◽  
Cardiac Valve ◽  
Control Group ◽  
Preventive Effect ◽  
Carrier System ◽  
Albumin Nanoparticles ◽  
Postoperative Thrombosis ◽  
Cardiac Valve Replacement ◽  
Average Size ◽  
Experimental Group

After cardiac valve replacement, most patients will have different degrees of thrombosis, different parts of the thrombus, and even more frequent occurrence of postoperative thrombosis; therefore, the prevention of postoperative thrombosis is particularly important. The purpose of this study was to investigate the preventive effect of albumin nano tPA gene plasmid ultrasound microbubble carrier system on thrombosis, especially in cardiac valve. The experimental control method was used. Firstly, 11 dogs meeting the experimental requirements were selected. Secondly, the data of albumin nanoparticles and microbubbles were analyzed. The average size of albumin particles was 132.0 nm, the average size of microbubbles was 3.1 ± 1.6 μm, and the zeta potential was 13.70 ± 1.95 MV. The concentration of microbubbles was 4.2 ± 1.3 × 10/ml. Finally, 11 dogs were divided into two groups. The experimental group was treated with albumin nanoparticles ultrasound microbubble, and the others were the control group. It was found that the levels of tPA and D-dimer in the experimental group were significantly increased and maintained at a high level at 1 week after operation, and the prothrombin time was detected and the international normalized ratio was calculated at the same time. No significant changes were found in the experimental group.

Plasma β-thromboglobulin and Platelet Factor 4 Levels in Cardiac Valve Prosthesis

1979 ◽  
Author(s):  
G. Cella ◽  
D.A. Lane ◽  
V.V. Kakkar ◽  
A. Donato ◽  
Volta S. Dalla
Keyword(s):  
Valve Replacement ◽  
Cardiac Valve ◽  
Control Group ◽  
Valve Prosthesis ◽  
Platelet Factor ◽  
Group A ◽  
The Mean ◽  
Cardiac Valve Replacement ◽  
Group B

Thromboembolic complications occur frequently in patients who have undergone cardiac valve replacement and platelets are known to be actively involved in the pathogenesis of such thrombi, A method of in-vivo assessment of platelet function would be useful in the management of such patients. βTC and PF4 Levels, the indicators of platelet release reaction in-vivo were measured in 100 patients who had cardiac valve replacement at least six months previously) Group A-54 patients had porcine heterograft, Group B-32 patients had disc valves and Group C-14 patients had double valve replacement. Findings of these patients were compared with 50 controls. In the control group, the mean βTG was 27.6ng/ml, and PF4 9.0 ng/ml. In each of the three groups of operated patients, both mean βTC and PF 4 levels were significantly raised (p < 0.05). Group A 61.5 ng/ml and 26.5 ng/ml, Grout B 57.0 ng/ml and 19.6 ng/ml and Group C 63.0 ng/ml and 36.6 ng/ml respectively. Of the 100 cases studied, 57 involved mitral, 29 aortic and 14 multiple valve replacement. No significant differences were observed in βTC or PF4 plasma levels with the different type of valve involvement. The clinical implications of these results will be discussed.

scholarly journals STAINLESS STEEL DISC VALVE FOR CARDIAC VALVE REPLACEMENT

1965 ◽  
Vol 49 (4) ◽  
pp. 540-549 ◽  
Author(s):  
Kirkley R. Williams ◽  
Adair Rogers ◽  
Stanley J. Dudrick
Keyword(s):  
Stainless Steel ◽  
Valve Replacement ◽  
Cardiac Valve ◽  
Stainless Steel Disc ◽  
Steel Disc ◽  
Cardiac Valve Replacement

scholarly journals The effect of iodine and strumigens long-term foodborne intake on histometrical parameters of thyroid gland in gimmers

2013 ◽  
Vol 61 (5) ◽  
pp. 1365-1369
Author(s):  
Zdeněk Peksa ◽  
Jan Trávníček ◽  
Roman Konečný ◽  
František Jelínek ◽  
Hana Dušová ◽  
...  
Keyword(s):  
Thyroid Gland ◽  
Dry Matter ◽  
Experimental Period ◽  
Rapeseed Meal ◽  
Iodine Intake ◽  
Control Group ◽  
High Iodine ◽  
Average Size ◽  
Experimental Group

In 2010 and 2011 two experiments on gimmers of Šumava mountain sheep were performed. The first experiment was carried out on 12 animals (experimental period was 11 months); control group was fed with 3 mg I*kg−1 in dry matter per day and experimental group was fed with 5 mg I*kg−1 in dry matter per day. The second experiment lasted 10 months and it was carried out on 12 animals. Feed ration for control group contained 10 mg I*kg DM−1. Feed ration for experimental group contained 10 mg I*kg DM−1 too; moreover it included rapeseed meal and 1 g of sodium nitrate. The aim of the first experiment was focused on impact of high iodine intake on structure of thyroid gland. The aim of the second experiment was to discover effect of strumigens during high iodine intake on structure of thyroid gland. The animals were slaughtered after the experiment and there was executed the dissection of thyroid gland. The samples of thyroid gland were processed during classic paraffin method and dyed with haematoxylin and eosin. For finding of histometrical parameters was used program Leica IM 500 Version 4.0. The length, the width and the area of follicles were measured. The follicles were divided into three groups after this procedure (by the length); in each group were measured 20 thyreocytes. In group with intake 5 mg I*kg DM−1 (experiment from year 2010): higher weight of thyroid (p < 0.01), significant higher (p < 0.05) proportional representation of large and medium follicles, significantly (p < 0.05) higher average size of follicles, demonstrably lower (p < 0.05) height of epithelium were found. There were not found any differences in monitored parameters between the groups from experiment which was carried out during the year 2011. After comparing results from the both experiments significantly higher percentage representation of large follicles a significantly lower representation of small follicles, distinctly higher average size and higher height of epithelium in all size categories, in groups with iodine intake 10 mg I*kg DM−1was found (from second experiment – year 2011).

Cardiac valve replacement in the elderly: Clinical performance of biological prostheses

1989 ◽  
Vol 48 (2) ◽  
pp. 173-185 ◽  
Author(s):  
W.R.Eric Jamieson ◽  
Lawrence H. Burr ◽  
A.Ian Munro ◽  
Robert T. Miyagishima ◽  
Alfred N. Gerein
Keyword(s):  
Valve Replacement ◽  
Clinical Performance ◽  
The Elderly ◽  
Cardiac Valve ◽  
Cardiac Valve Replacement ◽  
Biological Prostheses
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