scholarly journals To Clot or Not: HELLP Syndrome and Disseminated Intravascular Coagulation in an Eclamptic Patient with Intrauterine Fetal Demise

2020 ◽  
Vol 2020 ◽  
pp. 1-6
Author(s):  
Justin Walker ◽  
Anthony Bonavia
Keyword(s):  
Disseminated Intravascular Coagulation ◽  
Hellp Syndrome ◽  
Postoperative Management ◽  
Fetal Demise ◽  
Intravascular Coagulation ◽  
Medical Needs ◽  
Complex Patient ◽  
Intrauterine Fetal Demise ◽  
Work Up ◽  
Emergent Cesarean Section

A 39-year-old G2P1001 female presented from an outside hospital following an eclamptic seizure in the setting of HELLP syndrome. This condition was complicated by intrauterine fetal demise and disseminated intravascular coagulation, which required an emergent cesarean section. We report the work-up and intraoperative and postoperative management of this complex patient with multiple medical needs. We focus on the hemostatic abnormalities in this patient and describe how our management would differ from that of a similar, nonpregnant patient.

scholarly journals Successful application of recombinant activated factor VII in a patient with HELLP syndrome and disseminated intravascular coagulation

2008 ◽  
Vol 136 (Suppl. 3) ◽  
pp. 253-258
Author(s):  
Tatjana Ilic-Mostic ◽  
Rajka Argirovic ◽  
Radmila Sparic ◽  
Aleksandar Ljubic ◽  
Tatjana Bozanovic ◽  
...  
Keyword(s):  
Disseminated Intravascular Coagulation ◽  
Hellp Syndrome ◽  
Morbidity And Mortality ◽  
Factor Vii ◽  
Recombinant Activated Factor Vii ◽  
Fetal Demise ◽  
Intravascular Coagulation ◽  
Activated Factor Vii ◽  
Maternal Morbidity And Mortality ◽  
Mortality Case

INTRODUCTION. HELLP syndrome represents the form of preeclampsia characterized by moderate hypertension, often with absence of proteinuria and oedema. The frequency of HELLP syndrome in pregnant women with preeclampsia is 10-20%. The clinical course of the disease is characterized by the progressive worsening of mother and fetus condition, which can be stopped only by delivery. Disseminated intravascular coagulation is present in 8% of patients with HELLP syndrome and causes significant morbidity and mortality. CASE OUTLINE. We present a case of HELLP syndrome complicated by intrauterine fetal demise and disseminated intravascular coagulation in trigemelar pregnancy. After all surgical and medicamentous methods to establish haemostasis were exhausted, the patient was treated by recombinant activated factor VII (rFVIIa) in intravenous bolus dose of 90 ?g/kg twice, which resulted in satisfactory haemostasis. Side effects of the drug were not registered. CONCLUSION. The application of rFVIIa reduced haemorrhage in our patient, both after the Caesarean section and after hysterectomy, contributing to the patient?s full recovery, without neurological sequelae and with preserved renal function. RFVIIa is not an alternative to surgical haemostasis, but its administration should surely be considered before deciding to perform hysterectomy, especially in patients who want to preserve fertility. In cases of postpartum haemorrhage, when bleeding persists even after adequate surgical haemostasis, the administration of rFVIIa is to be considered not only as an alternative to hysterectomy, but also an effort to prevent significant maternal morbidity and mortality.

Disseminated intravascular coagulation in the HELLP syndrome: how much do we really know?

2016 ◽  
Vol 30 (7) ◽  
pp. 779-788 ◽  
Author(s):  
Kjell Haram ◽  
Jan Helge Mortensen ◽  
Salvatore Andrea Mastrolia ◽  
Offer Erez
Keyword(s):  
Disseminated Intravascular Coagulation ◽  
Hellp Syndrome ◽  
Intravascular Coagulation

scholarly journals Monitoring coagulation-fibrinolysis activation prompted timely diagnosis of hemophagocytic lymphohistiocytosis-related disseminated intravascular coagulation

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Liqin Ling ◽  
Xunbei Huang ◽  
Chaonan Liu ◽  
Juan Liao ◽  
Jing Zhou
Keyword(s):  
Disseminated Intravascular Coagulation ◽  
Hemophagocytic Lymphohistiocytosis ◽  
Early Stage ◽  
Score System ◽  
Intravascular Coagulation ◽  
Timely Diagnosis ◽  
Organ Failures ◽  
Diagnostic Work ◽  
New Biomarkers ◽  
Work Up

Abstract Background Timely diagnosis of disseminated intravascular coagulation (DIC) in hemophagocytic lymphohistiocytosis (HLH) patients is crucial but challenging, as HLH interferes with the results of the laboratory tests included in the DIC score system. Case presentation Here, we reported a case of lymphoma-associated HLH, in which coagulation-fibrinolysis activation /inhibition markers (TAT, tPAIC, and PIC), prompted timely diagnosis of early stage DIC (initial phase of microvascular thrombosis, yet non-overt), prior to the development of organ failures and/or bleedings. Conclusions This report highlights the importance of the implementation of new biomarkers (such as TAT, tPAIC, and PIC), into the diagnostic work-up for coagulation disorders. These biomarkers are directly suggestive of microthrombus formation, therefore they can be of paramount importance in diagnosing DIC with complicated etiologies, such as hematological diseases-related DIC.

scholarly journals Disseminated intravascular coagulation complicating HELLP syndrome: perioperative management

2009 ◽  
Vol 2009 (apr16 1) ◽  
pp. bcr1020081027-bcr1020081027 ◽  
Author(s):  
R. Garg ◽  
M P Nath ◽  
A P Bhalla ◽  
A. Kumar
Keyword(s):  
Disseminated Intravascular Coagulation ◽  
Hellp Syndrome ◽  
Perioperative Management ◽  
Intravascular Coagulation
Sign in / Sign up

Export Citation Format

Share Document