scholarly journals Monitoring coagulation-fibrinolysis activation prompted timely diagnosis of hemophagocytic lymphohistiocytosis-related disseminated intravascular coagulation

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Liqin Ling ◽  
Xunbei Huang ◽  
Chaonan Liu ◽  
Juan Liao ◽  
Jing Zhou
Keyword(s):  
Disseminated Intravascular Coagulation ◽  
Hemophagocytic Lymphohistiocytosis ◽  
Early Stage ◽  
Score System ◽  
Intravascular Coagulation ◽  
Timely Diagnosis ◽  
Organ Failures ◽  
Diagnostic Work ◽  
New Biomarkers ◽  
Work Up

Abstract Background Timely diagnosis of disseminated intravascular coagulation (DIC) in hemophagocytic lymphohistiocytosis (HLH) patients is crucial but challenging, as HLH interferes with the results of the laboratory tests included in the DIC score system. Case presentation Here, we reported a case of lymphoma-associated HLH, in which coagulation-fibrinolysis activation /inhibition markers (TAT, tPAIC, and PIC), prompted timely diagnosis of early stage DIC (initial phase of microvascular thrombosis, yet non-overt), prior to the development of organ failures and/or bleedings. Conclusions This report highlights the importance of the implementation of new biomarkers (such as TAT, tPAIC, and PIC), into the diagnostic work-up for coagulation disorders. These biomarkers are directly suggestive of microthrombus formation, therefore they can be of paramount importance in diagnosing DIC with complicated etiologies, such as hematological diseases-related DIC.

scholarly journals ALK-Negative Anaplastic Large Cell Lymphoma Presenting as Disseminated Intravascular Coagulation and Hemophagocytic Lymphohistiocytosis: A Potentially Fatal Presentation

2018 ◽  
Vol 2018 ◽  
pp. 1-3
Author(s):  
Uroosa Ibrahim ◽  
Amina Saqib ◽  
Maryam Rehan ◽  
Jean Paul Atallah
Keyword(s):  
Disseminated Intravascular Coagulation ◽  
Anaplastic Large Cell Lymphoma ◽  
Hemophagocytic Lymphohistiocytosis ◽  
Cell Lymphoma ◽  
Large Cell ◽  
Lymph Node Biopsy ◽  
Intravascular Coagulation ◽  
Primary Disorder ◽  
Life Threatening ◽  
Large Cell Lymphoma

Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening disorder that can be familial in etiology or a result of infections, malignancy, and autoimmune or inflammatory disorders. Disseminated intravascular coagulation (DIC) is common in patients admitted to intensive care units and can confound and delay the diagnosis of HLH. We present a case of a 69-year-old female who presented with dyspnea and malaise. Her condition declined rapidly with laboratory parameters consistent with DIC. In addition, she had a ferritin of 32,522 ng/mL, low haptoglobin, and elevated LDH, and bone marrow biopsy showed hemophagocytic lymphohistiocytes. She was started on HLH-directed therapy, and later, a diagnosis of ALK-negative anaplastic large cell lymphoma was made on an excisional inguinal lymph node biopsy specimen. Our case emphasizes the importance of prompt recognition, diagnosis, and treatment of HLH while workup for a primary disorder is still being pursued.

Hepatobiliary Dysfunction and Disseminated Intravascular Coagulation Increase Risk of Mortality in Pediatric Hemophagocytic Lymphohistiocytosis*

2018 ◽  
Vol 19 (10) ◽  
pp. e522-e530 ◽  
Author(s):  
Jordana Goldman ◽  
Moreshwar S. Desai ◽  
Kenneth L. McClain ◽  
M. Hossein Tcharmtchi ◽  
Curtis E. Kennedy ◽  
...  
Keyword(s):  
Disseminated Intravascular Coagulation ◽  
Hemophagocytic Lymphohistiocytosis ◽  
Intravascular Coagulation ◽  
Risk Of Mortality ◽  
Increase Risk

Disseminated Intravascular Coagulation and Acute Renal Failure

1971 ◽  
Vol 26 (02) ◽  
pp. 332-340 ◽  
Author(s):  
I Crîsnic ◽  
M Cucuianu ◽  
M Manasia ◽  
G Uza
Keyword(s):  
Renal Failure ◽  
Acute Renal Failure ◽  
Disseminated Intravascular Coagulation ◽  
Early Stage ◽  
Platelet Adhesiveness ◽  
Intravascular Coagulation ◽  
Clinical Observations ◽  
Lysis Time ◽  
Euglobulin Lysis Time

SummaryStarting from a hypothesis according to which disseminated intravascular coagulation might be an intermediary mechanism in the production of acute renal failure, investigations were made in 94 cases of anuria of different etiology, in order to detect signs of a consumption coagulopathy. After an average lapse of time of 48 h since the onset of anuria, the most frequently encountered hemostatic defect was a decreased platelet adhesiveness. In vitro experiments and clinical observations suggest that in the early stage of acute renal failure caused by a septic abortion, deficient platelet adhesiveness is due, mainly to platelet damage caused by intravascular coagulation or by bacterial toxins and not by the retention of metabolites. Euglobulin lysis time was prolonged, but a significant decrease of the plasminogen level indicates that an activation of fibrinolysis might have occured in the evolution of the process.

scholarly journals Linfohistiocitose Hemofagocítica Secundária a Infeção por Epstein-Barr: Raridade e Gravidade num Adulto Imunocompetente

2019 ◽  
Vol 32 (1) ◽  
pp. 78
Author(s):  
Andreia Sofia Costa ◽  
Anusca Paixão ◽  
Henrique Santos ◽  
Fernando Salvador
Keyword(s):  
Disseminated Intravascular Coagulation ◽  
Hemophagocytic Lymphohistiocytosis ◽  
Epstein Barr Virus ◽  
Clinical Case ◽  
Specific Treatment ◽  
Supportive Therapy ◽  
Intravascular Coagulation ◽  
Barr Virus ◽  
Life Threatening ◽  
Epstein Barr

Hemophagocytic lymphohistiocytosis is a rare, aggressive and life-threatening syndrome, characterized by an excessive immune activation. It is triggered by multiple stimuli, with infections having an important role. The most common infectious trigger is viral infection, particularly by Epstein-Barr virus. Coagulation disorders are common in hemophagocytic lymphohistiocytosis and disseminated intravascular coagulation can be present in severe cases. We report a clinical case of Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis, complicated with disseminated intravascular coagulation which evolved favorably with only supportive therapy and without specific treatment.

Systemic Inflammation and Disseminated Intravascular Coagulation in Early Stage of ALI and ARDS: Role of Neutrophil and Endothelial Activation

Inflammation ◽  
2004 ◽  
Vol 28 (4) ◽  
pp. 237-244 ◽  
Author(s):  
Satoshi Gando ◽  
Takashi Kameue ◽  
Naoyuki Matsuda ◽  
Atsushi Sawamura ◽  
Mineji Hayakawa ◽  
...  
Keyword(s):  
Systemic Inflammation ◽  
Disseminated Intravascular Coagulation ◽  
Early Stage ◽  
Endothelial Activation ◽  
Intravascular Coagulation

scholarly journals Thrombocytopenia in venocclusive disease after bone marrow transplantation or chemotherapy

Blood ◽  
1986 ◽  
Vol 67 (6) ◽  
pp. 1773-1776 ◽  
Author(s):  
B Rio ◽  
G Andreu ◽  
A Nicod ◽  
JP Arrago ◽  
F Dutrillaux ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Weight Gain ◽  
Bone Marrow Transplantation ◽  
Disseminated Intravascular Coagulation ◽  
Marrow Transplantation ◽  
Platelet Transfusion ◽  
Early Stage ◽  
Platelet Recovery ◽  
Intravascular Coagulation ◽  
Consumption Frequency

Abstract Hepatic venocclusive disease (VOD) is a frequent complication of bone marrow transplantation (BMT). Analysis of 13 cases observed during a 3- year period in our BMT center shows that VOD is associated with a constant peripheral thrombocytopenia and refractoriness to platelet transfusion. These signs appear in the very early stage of VOD, five to ten days before the classical signs, painful hepatomegaly and sudden weight gain. Analysis of platelet consumption, frequency of platelet transfusion and platelet recovery, and examination of known causes of peripheral thrombocytopenia (mainly allo- and autoimmunization, disseminated intravascular coagulation [DIC] and splenomegaly) lead to the conclusions that this association is not coincidental. The exact mechanism of platelet consumption in VOD is unknown.

Mycobacterium tuberculosis inducing disseminated intravascular coagulation

2005 ◽  
Vol 93 (04) ◽  
pp. 729-734 ◽  
Author(s):  
Jann-Yuan Wang ◽  
Po-Ren Hsueh ◽  
Yuang-Shuang Liaw ◽  
Wen-Yi Shau ◽  
Pan-Chyr Yang ◽  
...  
Keyword(s):  
Mortality Rate ◽  
Clinical Manifestation ◽  
Disseminated Intravascular Coagulation ◽  
Early Stage ◽  
Prognostic Significance ◽  
Clinical Manifestations ◽  
Clinical Findings ◽  
Mediastinal Lymphadenopathy ◽  
Disseminated Tuberculosis ◽  
Intravascular Coagulation

SummaryDisseminated intravascular coagulation (DIC) can develop infrequently in patients with tuberculosis and has a very high mortality rate. We conducted a retrospective study to evaluate the incidence of tuberculosis-induced DIC and to investigate the clinical manifestation, outcome, and prognostic factors of such patients. From January 2002 to December 2003, all culture-proven tuberculosis patients who developed DIC before starting anti-tuberculosis treatments were selected for this study. Patients who had other clinical conditions or were infected by other pathogens that may have been responsible for their DIC were excluded. Survival analysis was performed for each variable with possible prognostic significance. Our results showed that 27 (3.2%) out of the 833 patients with culture-proven tuberculosis had tuberculosis-induced DIC with a mortality rate of 63.0%. The most common clinical manifestations were fever (63.0%) and multiple patches of pulmonary consolidation (59.3%). Seven (25.9%) patients had disseminated tuberculosis. Twelve (44.4%) developed acute respiratory distress syndrome and three (11.1%) were associated with hemophagocytosis. Twenty-four (88.9%) patients had findings that were unusual for an acute bacterial infection, such as positive acid-fast smear, miliary pulmonary lesions, lymphocytotic exudative pleural effusion, and mediastinal lymphadenopathy. Early anti-tuberculosis treatment significantly improved survival. In conclusion, tuberculosis can cause DIC. Patients with non-miliary, non-disseminated tuberculosis could also develop the rare clinical manifestation. Since the prognosis was very poor in patients not treated at an early stage, a high index of suspicion is required, especially in those with clinical findings suggestive of tuberculosis.

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