scholarly journals Evaluation of Poly(Glycidyl Methacrylate) Nanocoating for Chiral Separation with Glu-β-CD as Chiral Selector in Capillary Electrophoresis

2021 ◽  
Vol 2021 ◽  
pp. 1-6
Author(s):  
Jin Xu ◽  
Xuecheng Sun ◽  
Xiaodong Sun ◽  
Ye Lu
Keyword(s):  
Capillary Electrophoresis ◽  
Chiral Separation ◽  
Ring Opening ◽  
Glycidyl Methacrylate ◽  
Chiral Selector ◽  
Separation Performance ◽  
Basic Drugs ◽  
Optimal Conditions ◽  
Simple Ring ◽  
Ring Opening Reaction

In this paper, a capillary coated with poly(glycidyl methacrylate) nanoparticles (PGMA NPs) was prepared and applied to construct a capillary electrophoresis (CE) enantioseparation system with glucosyl-β-cyclodextrin (Glu-β-CD) as a chiral selector. The PGMA NP coating can be easily introduced through a simple ring-opening reaction. Two basic drugs were used as models to evaluate the separation performance of the PGMA coating. Under the optimal conditions selected, the separation of the two enantiomers was obtained.

Fabrication of color changeable CO2 sensitive nanofibers

2017 ◽  
Vol 8 (48) ◽  
pp. 7446-7451 ◽  
Author(s):  
Jiaojiao Shang ◽  
Shaojian Lin ◽  
Patrick Theato
Keyword(s):  
Ring Opening ◽  
Glycidyl Methacrylate ◽  
Ring Opening Reaction ◽  
Nucleophilic Ring Opening

A CO2 sensor was fabricated by attaching CO2-sensitive spiropyran groups onto versatile photo-crosslinked poly(glycidyl methacrylate) (PGMA) precursor nanofibers via a nucleophilic ring-opening reaction.

scholarly journals Enantioseparation and Determination of Mephedrone and Its Metabolites by Capillary Electrophoresis Using Cyclodextrins as Chiral Selectors

Molecules ◽  
2020 ◽  
Vol 25 (12) ◽  
pp. 2879
Author(s):  
Pavel Řezanka ◽  
Denisa Macková ◽  
Radek Jurok ◽  
Michal Himl ◽  
Martin Kuchař
Keyword(s):  
Capillary Electrophoresis ◽  
Chiral Separation ◽  
Simplex Method ◽  
Background Electrolyte ◽  
Detection Limits ◽  
Chiral Selector ◽  
Designer Drug ◽  
Optimal Composition ◽  
Linear Calibration

Mephedrone, a psychoactive compound derived from cathinone, is widely used as a designer drug. The determination of mephedrone and its metabolites is important for understanding its possible use in medicine. In this work, a method of capillary electrophoresis for the chiral separation of mephedrone and its metabolites was developed. Carboxymethylated β-cyclodextrin was selected as the most effective chiral selector from seven tested cyclodextrin derivates. Based on the simplex method, the optimal composition of the background electrolyte was determined: at pH 2.75 and 7.5 mmol·L−1 carboxymethylated β-cyclodextrin the highest total resolution of a mixture of analytes was achieved. For mephedrone and its metabolites, calibration curves were constructed in a calibration range from 0.2 to 5 mmol·L−1; limits of detection, limits of quantification, precision, and repeatability were calculated, and according to Mandel’s fitting test, the linear calibration ranges were determined.

Chiral separation of basic drugs by capillary electrophoresis with carboxymethylcyclodextrins

2002 ◽  
Vol 948 (1-2) ◽  
pp. 331-342 ◽  
Author(s):  
Janusz Zukowski ◽  
Vern De Biasi ◽  
Alain Berthod
Keyword(s):  
Capillary Electrophoresis ◽  
Chiral Separation ◽  
Basic Drugs
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