scholarly journals Association of NFE2L2 Gene Polymorphisms with Risk and Clinical Characteristics of Acute Type A Aortic Dissection in Han Chinese Population

2021 ◽  
Vol 2021 ◽  
pp. 1-9
Author(s):  
Yiran Zhang ◽  
Qi Zheng ◽  
Ruoshi Chen ◽  
Xiaoyi Dai ◽  
Yimin Zhu ◽  
...  
Keyword(s):  
Aortic Dissection ◽  
Gene Polymorphisms ◽  
Chinese Population ◽  
Clinical Characteristics ◽  
Type A ◽  
Han Chinese ◽  
Control Group ◽  
Acute Type ◽  
Type A Aortic Dissection ◽  
Han Chinese Population

The present study is aimed at investigating the association of NFE2L2 gene polymorphisms with risk and clinical characteristics of acute type A aortic dissection (AAAD) in a Han Chinese population. Six SNPs (rs1806649, rs13001694, rs2364723, rs35652124, rs6721961, and rs2706110) in NFE2L2 were genotyped using SNaPshot Multiplex Kit in 94 adult patients diagnosed with AAAD at our hospital, and 208 healthy Han Chinese subjects from the 1000 Genomes Project were served as the control group. The CC genotype of rs2364723 (CC versus (GC+GG), OR = 2.069 , 95% CI: 1.222-3.502, p = 0.006 ) and CC genotype of rs35652124 (CC versus (CT+TT), OR = 1.889 , 95% CI: 1.112-3.210, p = 0.018 ) were identified as risk factors for AAAD. Multivariable linear regression analysis revealed that the CC genotype of rs2364723 ( β = 5.031 , 95% CI: 1.878-8.183, p = 0.002 ) and CC genotype of rs35652124 ( β = 4.751 , 95% CI: 1.544-7.958, p = 0.004 ) were associated with increased maximum ascending aorta diameter of AAAD. Patients carrying rs2364723 CC genotype had a higher incidence of coronary artery involvement (31% vs. 12%, p = 0.027 ), while patients carrying rs35652124 CC genotype had a higher incidence of brain ischemia (9% vs. 0%, p = 0.045 ). In conclusion, NFE2L2 gene polymorphisms were correlated with risk and severity of AAAD in Han Chinese population.

Aortic elongation part II: the risk of acute type A aortic dissection

Heart ◽  
2018 ◽  
Vol 104 (21) ◽  
pp. 1778-1782 ◽  
Author(s):  
Samuel Heuts ◽  
Bouke P Adriaans ◽  
Suzanne Gerretsen ◽  
Ehsan Natour ◽  
Rein Vos ◽  
...  
Keyword(s):  
Aortic Dissection ◽  
Propensity Scores ◽  
Three Dimensional ◽  
Type A ◽  
Prophylactic Surgery ◽  
Control Group ◽  
Acute Type ◽  
Healthy Controls ◽  
Cross Sectional ◽  
Type A Aortic Dissection

ObjectivesProphylactic surgery for prevention of acute type A aortic dissection (ATAAD) is reserved for patients with an ascending aortic aneurysm ≥55 mm. Identification of additional risk predictors is warranted since over 70% of patients presenting with ATAAD have a non-dilated aorta or an aneurysm that would not have met the diameter criterion for preventative surgery. Aim of the study was to evaluate ascending aortic elongation as a risk factor for ATAAD and to compare aortic lengths between ATAAD patients and healthy controls.MethodsAortic lengths and diameters of ATAAD patients were measured on three-dimensional modelled computed tomography and adjusted to predissection dimensions in this cross-sectional single-centre study. Logistic regression was used to evaluate the relation between ATAAD and aortic dimensions. Lengths of different aortic segments were compared with a healthy control group using propensity score matching.ResultsTwo-hundred and fifty patients were included in the study (ATAAD, n=40; controls, n=210). Ascending aortic length and diameter proved to be independent predictors for ATAAD (OR=5.3, CI 2.5 to 11.4, p<0.001 and OR=8.6, CI 2.4 to 31.0, p=0.001). Eighty patients were matched based on propensity scores (ATAAD n=40, controls n=40). The ascending aorta was longer and more dilated in ATAAD patients compared with healthy controls (78.6±8.8 mm vs 68.9±7.2 mm, p<0.001, 34.4 mm ±3.2. vs 39.4 mm ±5.7, p<0.001, respectively). No differences were found in lengths of the aortic arch and descending aorta.ConclusionsAscending aortic length could serve as an independent predictor for ATAAD. Future studies addressing indications for prophylactic surgery should also investigate aortic length.

scholarly journals Acute type A aortic dissection in the elderly: clinical characteristics, management, and outcomes in the current era

2002 ◽  
Vol 40 (4) ◽  
pp. 685-692 ◽  
Author(s):  
Rajendra H. Mehta ◽  
Patrick T. O’Gara ◽  
Eduardo Bossone ◽  
Christoph A. Nienaber ◽  
Truls Myrmel ◽  
...  
Keyword(s):  
Aortic Dissection ◽  
Clinical Characteristics ◽  
Type A ◽  
The Elderly ◽  
Acute Type ◽  
Type A Aortic Dissection

scholarly journals CD36 Gene Polymorphisms Are Associated with Intracerebral Hemorrhage Susceptibility in a Han Chinese Population

2017 ◽  
Vol 2017 ◽  
pp. 1-7 ◽  
Author(s):  
Qiu-Wen Gong ◽  
Mao-Fan Liao ◽  
Liang Liu ◽  
Xiao-Yi Xiong ◽  
Qin Zhang ◽  
...  
Keyword(s):  
Intracerebral Hemorrhage ◽  
Gene Polymorphisms ◽  
Chinese Population ◽  
Han Chinese ◽  
Controlled Study ◽  
Control Group ◽  
Dominant Model ◽  
Nucleotide Polymorphisms ◽  
Han Chinese Population ◽  
Cd36 Gene

The CD36 gene encodes a membrane glycoprotein (type B scavenger receptor, SR-B2) that plays a crucial role in lipid sensing, innate immunity, atherogenesis, and glycolipid metabolism. In this study, we aimed to investigate the association between CD36 gene polymorphisms and intracerebral hemorrhage (ICH) in a Han Chinese population. We performed genotype and allele analyses for eleven single nucleotide polymorphisms (SNPs) of CD36 in a case-controlled study involving 292 ICH patients and 298 control participants. Eleven SNPs were genotyped by the Improved Multiple Ligase Detection Reaction (iMLDR) method. The results indicated that the SNP rs1194182 values were significantly different between ICH group and control group in a dominant model after adjusting for confounding factors. The subgroup analysis conducted for rs1194182 showed that the allele G frequencies were significantly different between ICH patients and controls in hypertension group via a dominant model. We then analyzed the rs1194182 genotype distributions among different groups of the serum lipid groups, including BMI, TC, TG, HDL, and LDL. However, no significant differences were found in the analysis of other subgroups. Taken together, these findings indicate that rs1194182 polymorphism in the CD36 gene was associated with ICH, and genotype GG could be an independent predictor.

Differences in Clinical Characteristics, Management, and Outcomes of Intraoperative Versus Spontaneous Acute Type A Aortic Dissection

2013 ◽  
Vol 95 (1) ◽  
pp. 41-45 ◽  
Author(s):  
Sotiris C. Stamou ◽  
Nicholas T. Kouchoukos ◽  
Robert C. Hagberg ◽  
Craig R. Smith ◽  
Marcy Nussbaum ◽  
...  
Keyword(s):  
Aortic Dissection ◽  
Clinical Characteristics ◽  
Type A ◽  
Acute Type ◽  
Type A Aortic Dissection

scholarly journals Research on clinical characteristics and prognostic analysis of heparin-induced thrombocytopenia after surgery for acute type a aortic dissection

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Chu-zhi Zhou ◽  
Dong-jie Feng ◽  
Yuan Fang ◽  
Feng-yan Zha ◽  
Er-hui Wang ◽  
...  
Keyword(s):  
Aortic Dissection ◽  
Clinical Characteristics ◽  
Blood Platelets ◽  
Type A ◽  
Acute Type ◽  
Heparin Induced Thrombocytopenia ◽  
Type A Aortic Dissection ◽  
Icu Stay ◽  
Prognostic Analysis ◽  
Length Of Icu Stay

Abstract Purpose The present study aimed to explore the clinical characteristics of heparin-induced thrombocytopenia (HIT) after surgery for acute type A aortic dissection and perform a relevant prognostic analysis. Methods After continuous observation and analysis of 204 patients who underwent acute type A aortic dissection, we found that blood platelets decreased significantly after surgery and that these patients can be suspected to suffer HIT based on relevant 4Ts scores. For these suspected HIT patients, a latex particle-enhanced immunoturbidimetric assay was conducted to detect heparin-induced antibodies. Perioperative clinical data of patients in HIT and non-HIT groups were recorded as were blood platelet counts, HIT antibody test results, 4Ts scores, thromboembolic complications, clinical prognosis and outcomes. Results In the present study, 38 suspected HIT patients, 16 HIT patients and 188 non-HIT patients were selected in the clinical setting. Among them, HIT patients were found to have prolonged cardiopulmonary bypass time (223 min on average vs. 164 min) and delayed aortic cross-clamp time (128 min on average vs. 107 min), and these differences between HIT patients and non-HIT patients were significant (P < 0.05). Additionally, the HIT group required longer operation time and higher dose of heparin, but showing no statistical differences (P > 0.05). The transfusions of blood platelets in the HIT group and non-HIT group were 18.7 ± 5.0u and 15.6 ± 7.34 u, respectively. In the HIT group, the mechanic ventilation time and the length of ICU stay were longer comparing the non-HIT group(P < 0.05), though no significant differences in total length of stay or In-hospital mortality were observed (P > 0.05). The incidence of continuous renal replacement therapy in HIT group was higher than the non-HIT group (P < 0.05). Additionally,there were no significant differences in 24-h postoperative drainage or reoperation for bleeding in both group(P > 0.05). However, the HIT antibody titer in the HIT group was significantly higher than that in the Suspected HIT group (2.7 ± 0.8 U/mL vs. 0.3 ± 0.2 U/mL) (P < 0.05). Among patients diagnosed with HIT, the incidence of thromboembolism reached 31.5%.For example, two HIT patients newly developed thromboembolism in both lower extremities,and three patients experienced cerebral infarction. Conclusions After surgery for acute type A aortic dissection, HIT patients developed postoperative complications, the duration of ventilatory support and length of ICU stay were extended, and the incidence of thromboembolism increased. HIT antibody detection and risk classification should be implemented for high-risk patients showing early clinical characteristics.

scholarly journals Research on Clinical Characteristics and Prognostic Analysis of Heparin-Induced Thrombocytopenia After Surgery for Acute Type a Aortic Dissection

2020 ◽  
Author(s):  
Chu-zhi Zhou ◽  
Yan-zhen Li ◽  
Dong-jie Feng ◽  
Yuan Fang ◽  
Feng-yan Zha ◽  
...  
Keyword(s):  
Aortic Dissection ◽  
Clinical Characteristics ◽  
Blood Platelets ◽  
Type A ◽  
Acute Type ◽  
Heparin Induced Thrombocytopenia ◽  
Type A Aortic Dissection ◽  
Icu Stay ◽  
Prognostic Analysis ◽  
Length Of Icu Stay

Abstract PurposeThe present study aimed to explore the clinical characteristics of heparin-induced thrombocytopenia (HIT) after surgery for acute type A aortic dissection and perform a relevant prognostic analysis. MethodsAfter continuous observation and analysis of 204 patients who underwent acute type A aortic dissection, we found that blood platelets decreased significantly after surgery and that these patients can be suspected to suffer HIT based on relevant 4Ts scores. For these suspected HIT patients, a latex particle-enhanced immunoturbidimetric assay was conducted to detect heparin-induced antibodies. Perioperative clinical data of patients in HIT and non-HIT groups were recorded as were blood platelet counts, HIT antibody test results, 4Ts scores, thromboembolic complications, clinical prognosis and outcomes. ResultsIn the present study, 38 suspected HIT patients, 16 HIT patients and 188 non-HIT patients were selected in the clinical setting. Among them, HIT patients were found to have prolonged cardiopulmonary bypass time(223min on average vs. 164min) and delayed aortic cross-clamp time(128min on average vs. 107min), and these differences between HIT patients and non-HIT patients were significant (P<0.05). Additionally, the HIT group required longer operation time and higher dose of heparin, but showing no statistical differences(P>0.05). The transfusions of blood platelets in the HIT group and non-HIT group were 18.7±5.0u and 15.6±7.34 u, respectively.In the HIT group, the mechanic ventilation time and the length of ICU stay were longer comparing the non-HIT group(P<0.05), though no significant differences in total length of stay or In-hospital mortality were observed (P>0.05).The incidence of continuous renal replacement therapy in HIT group was higher than the non-HIT group(P<0.05). Additionally,there were no significant differences in 24-h postoperative drainage or reoperation for bleeding in both group(P>0.05). However, the HIT antibody titer in the HIT group was significantly higher than that in the Suspected HIT group(2.7±1.8U/mL vs. 0.3±0.2U/mL)(P<0.05).Among patients diagnosed with HIT, the incidence of thromboembolism reached 31.5%.For example, two HIT patients newly developed thromboembolism in both lower extremities,and three patients experienced cerebral infarction. ConclusionsAfter surgery for acute type A aortic dissection, HIT patients developed postoperative complications, the duration of ventilatory support and length of ICU stay were extended, and the incidence of thromboembolism increased. HIT antibody detection and risk classification should be implemented for high-risk patients showing early clinical characteristics.

scholarly journals Ascending Aortic Length and Its Association With Type A Aortic Dissection

2021 ◽  
Author(s):  
Daniella Eliathamby ◽  
Mariana Gutierrez ◽  
Aileen Liu ◽  
Maral Ouzounian ◽  
Thomas L. Forbes ◽  
...  
Keyword(s):  
Aortic Dissection ◽  
Innominate Artery ◽  
Type A ◽  
Ascending Aorta ◽  
Aortic Aneurysms ◽  
Control Group ◽  
Acute Type ◽  
Type A Aortic Dissection ◽  
Acute Dissection ◽  
Thoracic Aneurysms

Background The aim of this study was to determine the role of ascending aortic length and diameter in type A aortic dissection. Methods and Results Computed tomography scans from patients with acute type A dissections (n=51), patients with proximal thoracic aortic aneurysms (n=121), and controls with normal aortas (n=200) were analyzed from aortic annulus to the innominate artery using multiplanar reconstruction. In the control group, ascending aortic length correlated with diameter ( r 2 =0.35, P <0.001), age ( r 2 =0.17, P <0.001), and sex ( P <0.001). As a result of immediate changes in aortic morphology at the time of acute dissection, predissection lengths and diameters were estimated based on models from published literature. Ascending aortic length was longer in patients immediately following acute dissection (median, 109.7 mm; interquartile range [IQR], 101.0–115.1 mm), patients in the estimated predissection group (median, 104.2 mm; IQR, 96.0–109.3 mm), and patients in the aneurysm group (median, 107.0 mm; IQR, 99.6–118.7 mm) in comparison to controls (median, 83.2 mm; IQR, 74.5–90.7 mm) ( P <0.001 all comparisons). The diameter of the ascending aorta was largest in the aneurysm group (median, 52.0 mm; IQR, 45.9–58.0 mm), followed by the dissection group (median, 50.3 mm; IQR, 46.6–57.5 mm), and not significantly different between controls and the estimated predissection group (median, 33.4 mm [IQR, 30.7–36.7 mm] versus 35.2 mm [IQR, 32.6–40.3 mm], P =0.09). After adjustment for diameter, age, and sex, the estimated predissection aortic lengths were 16 mm longer than those in the controls and 12 mm longer than in patients with nondissected thoracic aneurysms. Conclusions The length of the ascending aorta, after adjustment for age, sex, and aortic diameter, may be useful in discriminating patients with type A dissection from normal controls and patients with nondissected thoracic aneurysms.

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