scholarly journals Acute Hepatitis A Causing Severe Hemolysis and Renal Failure in Undiagnosed Glucose-6-Phosphate Dehydrogenase Deficient Patient: A Case Report and Review of the Literature

2021 ◽  
Vol 2021 ◽  
pp. 1-8
Author(s):  
Iman Abutineh ◽  
Kyle Kreitman ◽  
Jiten P. Kothadia ◽  
Bilal Ali ◽  
Richa Jain ◽  
...  
Keyword(s):  
Renal Failure ◽  
Acute Hepatitis ◽  
G6pd Deficiency ◽  
Hepatitis A ◽  
Hepatitis A Virus ◽  
Review Of The Literature ◽  
Acute Hepatitis A ◽  
Deficient Patient ◽  
Glucose 6 Phosphate Dehydrogenase ◽  
Uncommon Complication

Infection with hepatitis A virus is usually a self-limited illness that rarely results in fulminant liver failure. Severe hemolysis is an uncommon complication but has been reported in patients with glucose-6-phosphate dehydrogenase (G6PD) deficiency. Here, we report a case with undiagnosed G6PD deficiency who presented with hyperbilirubinemia, severe hemolysis, and acute renal failure precipitated by acute hepatitis A infection.

scholarly journals S3531 Acute Hepatitis a Causing Severe Hemolysis and Renal Failure in a Glucose-6-Phosphate Dehydrogenase Deficient Patient

2020 ◽  
Vol 115 (1) ◽  
pp. S13-S14
Author(s):  
Kyle R. Kreitman ◽  
Jiten P. Kothadia ◽  
Richa Jain ◽  
Ian Clark ◽  
Benedict Maliakkal ◽  
...  
Keyword(s):  
Renal Failure ◽  
Acute Hepatitis ◽  
Hepatitis A ◽  
Acute Hepatitis A ◽  
Deficient Patient ◽  
Glucose 6 Phosphate Dehydrogenase

scholarly journals Prolonged and biphasic acute hepatitis A in hepatitis B virus carrier

2016 ◽  
Vol 10 ◽  
Author(s):  
Elena Garlatti Costa ◽  
Michela Ghersetti ◽  
Silvia Grazioli ◽  
Pietro Casarin
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Acute Hepatitis ◽  
Hepatitis A ◽  
Hepatitis A Virus ◽  
Inactive Carrier ◽  
B Virus ◽  
Acute Hepatitis A ◽  
Hepatitis B Virus Carrier ◽  
Life Threatening

Acute hepatitis A is generally a self-limited disease in healthy subjects within few weeks, but an uncommon type of prolonged and biphasic acute course of hepatitis A infection has been also described. This type of presentation is observed in about 6-10% of patients, but a small number of reports, concerning this topic, are available in literature. In addition hepatitis A virus (HAV) infection in hepatitis B virus (HBV) carriers has rarely been discussed. A 41-year-old Italian man, already known to our Department for HBV infection as an inactive carrier HBsAg(+)ve, experienced a prolonged and biphasic course of acute hepatitis A, lasting about 7 months. In this patient possible factors, causing the second flare of transaminases, were excluded (in particular autoimmunity). Liver biopsy as well HAV RNA search in blood/stools were not performed. In conclusion, the hepatologist should take into account this type of atypical course in patients with HAV-related hepatitis and should promote HAV vaccination in subjects with HBV-chronic hepatitis, to prevent possible life-threatening acute exacerbation of hepatic damage, mainly in HBV-carriers with more severe forms of liver diseases.

Clinical and virological features of acute hepatitis A during an ongoing outbreak among men who have sex with men in the North of France

2018 ◽  
Vol 95 (1) ◽  
pp. 75-77 ◽  
Author(s):  
Anne Boucher ◽  
Agnes Meybeck ◽  
Kazali Alidjinou ◽  
Thomas Huleux ◽  
Nathalie Viget ◽  
...  
Keyword(s):  
Acute Hepatitis ◽  
Hepatitis A ◽  
Hepatitis A Virus ◽  
Healthcare Providers ◽  
High Rate ◽  
Missed Opportunities ◽  
The North ◽  
Acute Hepatitis A ◽  
History Of ◽  
Sex With Men

ObjectivesSince February 2017, an increase of acute hepatitis A (AHA) cases has been notified in North of France. We aimed to report clinical and virological features of 49 cases treated in three hospitals in Lille European Metropolis (LEM).MethodsAll adult patients treated for AHA in 3 LEM hospitals between 20 February and 5 July 2017 were included. Demographic characteristics, exposure risk factors to hepatitis A virus (HAV), AHA manifestations and concomitant sexually transmitted infections (STI) were retrospectively recorded.ResultsForty-nine cases of AHA were diagnosed among which 34 (69%) were hospitalised. Severe AHA occurred in 7 (14%) patients. The median age of cases was 36 years. All cases except 1 were men and 32 (65%) were identified as men having sex with men (MSM). Eleven (23%) patients were HIV-infected, 5 were under HIV pre-exposure prophylaxis (PrEP), 6 had a history of HIV postexposure prophylaxis and 19 had a history of at least one STI. Only three patients had received HAV vaccine. Proportion of patients tested for syphilis, chlamydial and gonococcal infections was 75% (18/24) in those seen by sexual health specialists and 21% (6/29) in those seen by other specialists. At least one concomitant STI was diagnosed in 13 out of 24 tested patients (54%). RT-PCR sequencing was available for 38 cases and confirmed co-circulation of 3 different strains of subgenotype IA (VRD 521 2016: n=24, RIVM-HAV16-090: n=13, V16-25801: n=1), already identified in several European countries.ConclusionsWe are facing an outbreak of AHA among MSM in the North of France with a high rate of hospitalisation. Analysis of cases highlighted missed opportunities of vaccination and lack of concomitant STI screening. Awareness among healthcare providers and MSM should be increased and HAV vaccination promoted.

Characteristics of acute hepatitis A virus infection before and after 2001: A hospital‐based study in Tokyo, Japan

2019 ◽  
Vol 34 (10) ◽  
pp. 1836-1842 ◽  
Author(s):  
Tomomi Kogiso ◽  
Takaomi Sagawa ◽  
Mayuko Oda ◽  
Somura Yoshiko ◽  
Kazuhisa Kodama ◽  
...  
Keyword(s):  
Virus Infection ◽  
Acute Hepatitis ◽  
Hepatitis A ◽  
Hepatitis A Virus ◽  
Acute Hepatitis A ◽  
Before And After

Vestibular Hyperreflexia and Opsoclonus in Acute Hepatitis A Virus Infection

2019 ◽  
Vol 18 (6) ◽  
pp. 1151-1153 ◽  
Author(s):  
Sun-Uk Lee ◽  
Juyoung Lee ◽  
Hyo-Jung Kim ◽  
Jeong-Yoon Choi ◽  
Hui Jong Oh ◽  
...  
Keyword(s):  
Virus Infection ◽  
Acute Hepatitis ◽  
Hepatitis A ◽  
Hepatitis A Virus ◽  
Acute Hepatitis A

scholarly journals Acute Cholestatic Hepatitis A Virus Infection Presenting with Hemolytic Anemia and Renal Failure: A Case Report

2013 ◽  
Vol 2013 ◽  
pp. 1-4 ◽  
Author(s):  
Robert T. Lapp ◽  
Fedja Rochling
Keyword(s):  
Renal Failure ◽  
Virus Infection ◽  
Plasma Exchange ◽  
Hemolytic Anemia ◽  
Hepatitis A ◽  
Hepatitis A Virus ◽  
Cholestatic Hepatitis ◽  
Packed Red Blood Cells ◽  
First Case ◽  
Acute Hepatitis A

Hepatitis A virus is the most common acute viral hepatitis worldwide with approximately 1.5 million cases annually. Hepatitis A virus infection in general is self-limited. In rare cases, hepatitis A virus infection may cause renal failure, hemolytic anemia, and/or cholestasis. We report the first case of acute cholestatic hepatitis A virus infection complicated by hemolytic anemia, and renal failure in one patient. A 42-year-old Caucasian male presented with cholestasis, hemolytic anemia and renal failure after consuming street tacos in Central and South America while on a business trip. His protracted course required corticosteroid therapy, multiple sessions of plasma exchange, and numerous units of packed red blood cells. This case demonstrates the importance of vaccination in high-risk adults. A prompt diagnosis of acute hepatitis A virus infection is essential, as uncommon presentations may delay diagnosis leading to permanent morbidity and potentially death in fulminant cases. We also demonstrate the efficacy of treatment of cholestatic hepatitis A virus infection, hemolytic anemia, and renal failure with corticosteroids and plasma exchange.

Acute Hepatitis A Virus Infection Without IgM Antibodies to Hepatitis A Virus

2011 ◽  
Vol 154 (7) ◽  
pp. 507 ◽  
Author(s):  
Catherine Chakvetadze ◽  
Vincent Mallet ◽  
Laure Gaussec ◽  
Laurent Hannoun ◽  
Stanislas Pol
Keyword(s):  
Virus Infection ◽  
Acute Hepatitis ◽  
Hepatitis A ◽  
Hepatitis A Virus ◽  
Igm Antibodies ◽  
Acute Hepatitis A
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