Clinical and virological features of acute hepatitis A during an ongoing outbreak among men who have sex with men in the North of France

2018 ◽  
Vol 95 (1) ◽  
pp. 75-77 ◽  
Author(s):  
Anne Boucher ◽  
Agnes Meybeck ◽  
Kazali Alidjinou ◽  
Thomas Huleux ◽  
Nathalie Viget ◽  
...  
Keyword(s):  
Acute Hepatitis ◽  
Hepatitis A ◽  
Hepatitis A Virus ◽  
Healthcare Providers ◽  
High Rate ◽  
Missed Opportunities ◽  
The North ◽  
Acute Hepatitis A ◽  
History Of ◽  
Sex With Men

ObjectivesSince February 2017, an increase of acute hepatitis A (AHA) cases has been notified in North of France. We aimed to report clinical and virological features of 49 cases treated in three hospitals in Lille European Metropolis (LEM).MethodsAll adult patients treated for AHA in 3 LEM hospitals between 20 February and 5 July 2017 were included. Demographic characteristics, exposure risk factors to hepatitis A virus (HAV), AHA manifestations and concomitant sexually transmitted infections (STI) were retrospectively recorded.ResultsForty-nine cases of AHA were diagnosed among which 34 (69%) were hospitalised. Severe AHA occurred in 7 (14%) patients. The median age of cases was 36 years. All cases except 1 were men and 32 (65%) were identified as men having sex with men (MSM). Eleven (23%) patients were HIV-infected, 5 were under HIV pre-exposure prophylaxis (PrEP), 6 had a history of HIV postexposure prophylaxis and 19 had a history of at least one STI. Only three patients had received HAV vaccine. Proportion of patients tested for syphilis, chlamydial and gonococcal infections was 75% (18/24) in those seen by sexual health specialists and 21% (6/29) in those seen by other specialists. At least one concomitant STI was diagnosed in 13 out of 24 tested patients (54%). RT-PCR sequencing was available for 38 cases and confirmed co-circulation of 3 different strains of subgenotype IA (VRD 521 2016: n=24, RIVM-HAV16-090: n=13, V16-25801: n=1), already identified in several European countries.ConclusionsWe are facing an outbreak of AHA among MSM in the North of France with a high rate of hospitalisation. Analysis of cases highlighted missed opportunities of vaccination and lack of concomitant STI screening. Awareness among healthcare providers and MSM should be increased and HAV vaccination promoted.

scholarly journals Outbreak of acute hepatitis A associated with men who have sex with men (MSM) in North Sardinia 2017-2018

2020 ◽  
Vol 14 (09) ◽  
pp. 1065-1070 ◽  
Author(s):  
Riccardo Bazzardi ◽  
Elena Dore ◽  
Massimo Ciccozzi ◽  
Alessia Lai ◽  
Margherita Pisanu ◽  
...  
Keyword(s):  
Acute Hepatitis ◽  
Hepatitis A ◽  
Hepatitis A Virus ◽  
P Value ◽  
Serum Samples ◽  
Sequencing Method ◽  
Acute Hepatitis A ◽  
Hiv Antibodies ◽  
Duration Of Hospitalization ◽  
Sex With Men

Introduction: We describe an outbreak of hepatitis A among men who have sex with men (MSM) which evolved in Sassari (Italy), between January 2017 and December 2018, close to a contextual of large concurrent hepatitis A outbreak reported in Europe and recently, in Italy. Methodology: HAV RNA detection and molecular characterization was performed from serum samples and/or stool by RT - PCR of VP1/2A junction region that ranges from nt. 2,873 to nt. 3,376. The phylogenetic correlation of the circulating hepatitis A strains was assessed by sequencing method according to the HAVNET protocol. Results: 10 Acute Hepatitis A virus (AHA)-positive cases, 8 of which were among men who have sex with men (MSM) were identified. All patients were tested at the time of hospitalization for the presence of anti-HIV antibodies, only two MSM resulted co-infected by HIV. No differences were observed in median age (37 years vs. 41 years, P-value = 0.14), severity or duration of hospitalization between seropositive and HIV-negative men. Phylogenetic analysis was conducted in 2 cases and revealed two distinct sequences of genotype IA linking to clusters recognized in MSM in other European countries in 2016. Conclusion: Our study reported a recent increase of notified hepatitis A cases attributable to cases in the European interconnectedness of MSM in Sassari, a small locality. Hepatitis A vaccination for MSM in Sardinia region is recommended; however, our data emphasize the need of hepatitis A screening and vaccination not only for MSM with occasional partners but also for those in monogamous relationships.

Acute hepatitis A infection after hepatitis A immunity in a HIV-positive individual

2017 ◽  
Vol 94 (1) ◽  
pp. 30-31 ◽  
Author(s):  
Ming Jie Lee ◽  
Sam Douthwaite ◽  
Ranjababu Kulasegaram
Keyword(s):  
Acute Hepatitis ◽  
Hepatitis A ◽  
Hepatitis A Virus ◽  
Oral Route ◽  
Sexual Practices ◽  
Hiv Positive ◽  
Previous Exposure ◽  
Positive Individual ◽  
Acute Hepatitis A ◽  
Sex With Men

Hepatitis A is a self-limiting infection caused by the hepatitis A virus (HAV), transmitted predominantly by the faecal–oral route including some sexual practices. Outbreaks are commonly reported in the men who have sex with men (population. Previous exposure is thought to provide life-long immunity against subsequent infections with the development of an HAV IgG response. This paper reports a case of acute Hepatitis A infection, despite evidence of a previously positive Hepatitis A IgG results in an HIV-positive individual.

scholarly journals Prolonged and biphasic acute hepatitis A in hepatitis B virus carrier

2016 ◽  
Vol 10 ◽  
Author(s):  
Elena Garlatti Costa ◽  
Michela Ghersetti ◽  
Silvia Grazioli ◽  
Pietro Casarin
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Acute Hepatitis ◽  
Hepatitis A ◽  
Hepatitis A Virus ◽  
Inactive Carrier ◽  
B Virus ◽  
Acute Hepatitis A ◽  
Hepatitis B Virus Carrier ◽  
Life Threatening

Acute hepatitis A is generally a self-limited disease in healthy subjects within few weeks, but an uncommon type of prolonged and biphasic acute course of hepatitis A infection has been also described. This type of presentation is observed in about 6-10% of patients, but a small number of reports, concerning this topic, are available in literature. In addition hepatitis A virus (HAV) infection in hepatitis B virus (HBV) carriers has rarely been discussed. A 41-year-old Italian man, already known to our Department for HBV infection as an inactive carrier HBsAg(+)ve, experienced a prolonged and biphasic course of acute hepatitis A, lasting about 7 months. In this patient possible factors, causing the second flare of transaminases, were excluded (in particular autoimmunity). Liver biopsy as well HAV RNA search in blood/stools were not performed. In conclusion, the hepatologist should take into account this type of atypical course in patients with HAV-related hepatitis and should promote HAV vaccination in subjects with HBV-chronic hepatitis, to prevent possible life-threatening acute exacerbation of hepatic damage, mainly in HBV-carriers with more severe forms of liver diseases.

Characteristics of acute hepatitis A virus infection before and after 2001: A hospital‐based study in Tokyo, Japan

2019 ◽  
Vol 34 (10) ◽  
pp. 1836-1842 ◽  
Author(s):  
Tomomi Kogiso ◽  
Takaomi Sagawa ◽  
Mayuko Oda ◽  
Somura Yoshiko ◽  
Kazuhisa Kodama ◽  
...  
Keyword(s):  
Virus Infection ◽  
Acute Hepatitis ◽  
Hepatitis A ◽  
Hepatitis A Virus ◽  
Acute Hepatitis A ◽  
Before And After

scholarly journals Acute Hepatitis A Outbreak Among Men Who Have Sex With Men in Krakow, Poland; February 2017–February 2018

2019 ◽  
Vol 13 (6) ◽  
pp. 155798831989514 ◽  
Author(s):  
Aleksandra Raczyńska ◽  
Nimmi Nimesha Wickramasuriya ◽  
Anna Kalinowska-Nowak ◽  
Aleksander Garlicki ◽  
Monika Bociąga-Jasik
Keyword(s):  
Chronic Hepatitis ◽  
Acute Hepatitis ◽  
Hepatitis A ◽  
Clinical Manifestations ◽  
Sexually Transmitted ◽  
Acute Retroviral Syndrome ◽  
Chronic Hepatitis B Virus ◽  
Route Of Transmission ◽  
Acute Hepatitis A ◽  
Sex With Men

Since February 2017 in Poland, an increasing number of acute hepatitis A (AHA) cases have been reported; a noteworthy increase to 3,072 cases of AHA in 2017 compared to 35 cases in 2016 was reported by the National Institute of Public Health (NIPH). The aim of this study was to evaluate the demographic features, clinical manifestations, laboratory results, and sexually transmitted coinfections. All cases of AHA diagnosed between February 2017 and February 2018 at the University Hospital in Krakow were analyzed. A total of 119 cases of hepatitis A virus (HAV) were reported; 105 (88%) were males and 14 (12%) were females, with a mean age 31 years (range 19–62). In 84 patients (71%), the HAV was transmitted by oral–anal sexual contact between men. Six women were infected by close house contact with men infected with HAV. The route of transmission was not identified for 29 cases, and 88 patients (74%) required hospitalization. Among the cases, the following coinfections were already diagnosed: HIV 36 patients (30%), chronic hepatitis C virus (HCV) 4 patients (3%), and chronic hepatitis B virus (HBV) 2 patients (1.5%). During AHA diagnosis, some new sexually transmitted infections (STIs) were detected; syphilis eight patients (6.7%), HIV/syphilis seven patients (6%), HIV//HCV/syphilis one patient, and acute retroviral syndrome/ Shigella flexneri one patient. Overall, AHA outbreak in Poland in 2017 affected primarily men who have sex with men (MSM) and was connected with oral–anal sexual contacts, and the majority of patients did not have HAV vaccination. These results show a clear need for routinely offering HAV vaccination to at-risk populations and that awareness among health-care workers about HAV sexual transmission may help introduce prevention methods.

Vestibular Hyperreflexia and Opsoclonus in Acute Hepatitis A Virus Infection

2019 ◽  
Vol 18 (6) ◽  
pp. 1151-1153 ◽  
Author(s):  
Sun-Uk Lee ◽  
Juyoung Lee ◽  
Hyo-Jung Kim ◽  
Jeong-Yoon Choi ◽  
Hui Jong Oh ◽  
...  
Keyword(s):  
Virus Infection ◽  
Acute Hepatitis ◽  
Hepatitis A ◽  
Hepatitis A Virus ◽  
Acute Hepatitis A
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