scholarly journals NCF1/2/4 Are Prognostic Biomarkers Related to the Immune Infiltration of Kidney Renal Clear Cell Carcinoma

2021 ◽  
Vol 2021 ◽  
pp. 1-31
Author(s):  
Yifei Chen ◽  
Fei He ◽  
Ruhua Wang ◽  
Menglin Yao ◽  
Yarui Li ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Clear Cell ◽  
Clear Cell Carcinoma ◽  
Genetic Alterations ◽  
Renal Clear Cell Carcinoma ◽  
Prognostic Biomarkers ◽  
Mrna Levels ◽  
Poor Overall Survival ◽  
Cytoplasmic Factor ◽  
Value Analysis

Neutrophil cytoplasmic factor 1/2/4 (NCF1/2/4) belongs to the NADPH oxidase complex, which is a cytoplasmic component, and its polymorphism is the main factor related to autoimmune diseases, which is probably caused by the regulation of peroxide. They also play a role in tumor growth and metastasis. This research is aimed at evaluating the biological function and prognostic role of NCF1, NCF2, and NCF4 genes in kidney renal clear cell carcinoma (KIRC) by using multiple online bioinformatics website, including Oncomine, GEPIA, UALCAN, Kaplan–Meier Plotter, TIMER, TISIDB, cBioPortal, LinkedOmics, GeneMANIA, and DAVID databases. The mRNA levels of NCFs were higher in KIRC tissues than in normal tissues. The overexpression of NCFs was significantly correlated with advanced pathological grades and individual cancer stages in KIRC. Meanwhile, the expressions of NCFs played an important role in the tumorigenesis and progression of KIRC. Prognostic value analysis suggested that high transcription levels of NCF1/4 were associated with poor overall survival in KIRC patients. In addition, results from the LinkedOmics database showed that the KEGG pathway related to NCFs mainly focused on immune activation and immune regulation function. NCF genetic alterations, including copy number amplification, missense mutation, and deep deletion, could be found through the cBioPortal database. Further, NCF expression was significantly correlated with infiltration levels of various immune cells as well as immune signatures. Protein-protein interaction network and enrichment analysis of NCF1/2/4 in KIRC showed that NCF coexpressed genes mainly associated with diverse immune marker sets showed significance. Overall, these results indicated that NCFs could be prognostic biomarkers as well as effective targets for diagnosis in KIRC.

scholarly journals Identifying prognostic biomarkers based on aberrant DNA methylation in kidney renal clear cell carcinoma

Oncotarget ◽  
2016 ◽  
Vol 8 (3) ◽  
pp. 5268-5280 ◽  
Author(s):  
Guang Chen ◽  
Yihan Wang ◽  
Lu Wang ◽  
Wanhai Xu
Keyword(s):  
Dna Methylation ◽  
Cell Carcinoma ◽  
Clear Cell ◽  
Clear Cell Carcinoma ◽  
Renal Clear Cell Carcinoma ◽  
Prognostic Biomarkers ◽  
Aberrant Dna Methylation

scholarly journals C3, C3AR1, HLA-DRA, and HLA-E as potential prognostic biomarkers for renal clear cell carcinoma

2020 ◽  
Vol 9 (6) ◽  
pp. 2640-2656
Author(s):  
Guangdi Chu ◽  
Wei Jiao ◽  
Xuecheng Yang ◽  
Ye Liang ◽  
Zhiqiang Li ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Clear Cell ◽  
Clear Cell Carcinoma ◽  
Renal Clear Cell Carcinoma ◽  
Prognostic Biomarkers

Expression of angiopoietins in renal epithelial and clear cell carcinoma cells: regulation by hypoxia and participation in angiogenesis

2004 ◽  
Vol 287 (4) ◽  
pp. F649-F657 ◽  
Author(s):  
Midori Yamakawa ◽  
Louis X. Liu ◽  
Adam J. Belanger ◽  
Taro Date ◽  
Takayuki Kuriyama ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Target Genes ◽  
Clear Cell ◽  
Clear Cell Carcinoma ◽  
Hypoxia Inducible Factor ◽  
Human Kidney ◽  
Renal Clear Cell Carcinoma ◽  
Tube Formation ◽  
Mrna Levels ◽  
Hybrid Form

The hereditary von Hippel-Lindau (VHL) syndrome predisposes sufferers to highly vascularized tumors such as renal clear cell carcinoma (RCC) and central nervous system hemangioblastoma. In RCC4 and RCC786–0 VHL− cells with VHL mutations, the protein of hypoxia-inducible factor-1α (HIF-1α) is constitutively stabilized and the mRNA levels of HIF target genes, including vascular endothelial growth factor (VEGF), are elevated. However, the expression of angiopoietins in these cells and their involvement in angiogenesis are not well known. In this study, we compared the mRNA levels of angiopoietins in human kidney proximal tubule epithelial (RPTE) and RCC4 and RCC786–0 VHL− cells. In RPTE cells, angiopoietin-4 (Ang-4) expression was selectively induced by hypoxia or by expression of a hybrid form of HIF-1α. Under normoxic conditions, the mRNA levels of Ang-4 were higher in RCC4 and RCC786–0 VHL− than RPTE cells. Angiopoietin-1 expression was detectable in RCC4 and RCC786–0 VHL− cells but not RPTE cells. In RCC786–0 VHL+ cells, which were stably transfected with a wild-type copy of VHL, the mRNA levels of VEGF and Ang-4 were suppressed and the hypoxic response was restored. We also demonstrated that stimulation of endothelial tube formation by conditioned medium harvested from RCC4 cells was inhibited by a soluble Tie-2 receptor. These results suggest that the angiopoietin/Tie-2 system may participate in the angiogenic response to hypoxia in renal tissues and in tumor angiogenesis in renal carcinoma.

scholarly journals Identification of a Novel Defined Immune-Autophagy-Related Gene Signature Associated With Clinical and Prognostic Features of Kidney Renal Clear Cell Carcinoma

2021 ◽  
Vol 8 ◽  
Author(s):  
Guangyuan Zhang ◽  
Lei Zhang ◽  
Si Sun ◽  
Ming Chen
Keyword(s):  
Cell Carcinoma ◽  
Immune Checkpoint ◽  
Prognostic Value ◽  
Cox Regression ◽  
Clear Cell ◽  
Clear Cell Carcinoma ◽  
Renal Clear Cell Carcinoma ◽  
Prognostic Biomarkers ◽  
Prognostic Features ◽  
Immune Score

Background: As a common cancer of the urinary system in adults, renal clear cell carcinoma is metastatic in 30% of patients, and 1–2 years after diagnosis, 60% of patients die. At present, the rapid development of tumor immunology and autophagy had brought new directions to the treatment of renal cancer. Therefore, it was extremely urgent to find potential targets and prognostic biomarkers for immunotherapy combined with autophagy.Methods: Through GSE168845, immune-related genes, autophagy-related genes, and immune-autophagy-related differentially expressed genes (IAR-DEGs) were identified. Independent prognostic value of IAR-DEGs was determined by differential expression analysis, prognostic analysis, and univariate and multivariate Cox regression analyses. Then, the lasso Cox regression model was established to evaluate the correlation of IAR-DEGs with the immune score, immune checkpoint, iron death, methylation, and one-class logistic regression (OCLR) score.Results: In this study, it was found that CANX, BID, NAMPT, and BIRC5 were immune-autophagy-related genes with independent prognostic value, and the risk prognostic model based on them was well constructed. Further analysis showed that CANX, BID, NAMPT, and BIRC5 were significantly correlated with the immune score, immune checkpoint, iron death, methylation, and OCLR score. Further experimental results were consistent with the bioinformatics analysis.Conclusion: CANX, BID, NAMPT, and BIRC5 were potential targets and effective prognostic biomarkers for immunotherapy combined with autophagy in kidney renal clear cell carcinoma.

Delayed Pancreatic Metastasis of Renal Clear Cell Carcinoma

2013 ◽  
Vol 13 (2) ◽  
pp. 79-80
Author(s):  
Zane Simtniece ◽  
Gatis Kirsakmens ◽  
Ilze Strumfa ◽  
Andrejs Vanags ◽  
Maris Pavars ◽  
...  
Keyword(s):  
Abdominal Pain ◽  
Surgical Treatment ◽  
Cell Carcinoma ◽  
Clear Cell ◽  
Clear Cell Carcinoma ◽  
Primary Tumour ◽  
Renal Clear Cell Carcinoma ◽  
Pancreatic Metastasis ◽  
Distal Pancreatic Resection

Abstract Here, we report surgical treatment of a patient presenting with pancreatic metastasis (MTS) of renal clear cell carcinoma (RCC) 11 years after nephrectomy. RCC is one of few cancers that metastasise in pancreas. Jaundice, abdominal pain or gastrointestinal bleeding can develop; however, asymptomatic MTS can be discovered by follow-up after removal of the primary tumour. The patient, 67-year-old female was radiologically diagnosed with a clinically silent mass in the pancreatic body and underwent distal pancreatic resection. The postoperative period was smooth. Four months after the surgery, there were no signs of disease progression.

Parotid metastasis of renal clear cell carcinoma: a case report

2009 ◽  
Vol 28 (10) ◽  
pp. 1271-1272
Author(s):  
Xiao-mei MA ◽  
Hui-min LIU
Keyword(s):  
Case Report ◽  
Cell Carcinoma ◽  
Clear Cell ◽  
Clear Cell Carcinoma ◽  
Renal Clear Cell Carcinoma

Protein interactions of cortactin in relation to invadopodia formation in metastatic renal clear cell carcinoma

Tumor Biology ◽  
2014 ◽  
Vol 36 (5) ◽  
pp. 3417-3422 ◽  
Author(s):  
Hong-Liang Shen ◽  
Qing-Jun Liu ◽  
Pei-Qian Yang ◽  
Ye Tian
Keyword(s):  
Cell Carcinoma ◽  
Protein Interactions ◽  
Clear Cell ◽  
Clear Cell Carcinoma ◽  
Renal Clear Cell Carcinoma ◽  
Invadopodia Formation
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