scholarly journals Sialolipoma of the Floor of the Mouth with Immunohistological Analysis

2021 ◽  
Vol 2021 ◽  
pp. 1-5
Author(s):  
Ahmed A. Zahrani ◽  
Ahmed Qannam ◽  
Ra’ed Al Sadhan ◽  
Ibrahim O. Bello
Keyword(s):  
Salivary Gland ◽  
Head And Neck ◽  
Salivary Glands ◽  
Floor Of The Mouth ◽  
Salivary Gland Tissue ◽  
Major Salivary Glands ◽  
Gland Tissue ◽  
Immunohistological Analysis

Lipomas are relatively rare in the head and neck, and sialolipoma was described as an entity about 20 years ago as lipoma that entraps salivary gland tissue. Less than 10 cases have been described in the floor of the mouth not related to the major salivary glands. Here, we report a case of sialolipoma affecting the floor of the mouth in a 47-year-old patient and reviewed the clinical, histologic, and immunohistochemical characteristics of the lesion.

A review of heterotopia and associated salivary gland neoplasms of the head and neck

1999 ◽  
Vol 113 (4) ◽  
pp. 299-303 ◽  
Author(s):  
Alfio Ferlito ◽  
Giulia Bertino ◽  
Alessandra Rinaldo ◽  
Giacinto M. Mannarà ◽  
Kenneth O. Devaney
Keyword(s):  
Salivary Gland ◽  
Head And Neck ◽  
Critical Review ◽  
Neck Mass ◽  
Diagnostic Assessment ◽  
Review Of The Literature ◽  
Salivary Gland Tissue ◽  
Gland Tissue ◽  
Node Involvement ◽  
Warthin’S Tumour

AbstractSalivary tissue neoplasms may involve normal, accessory and heterotopic salivary gland tissue. A case of Warthin's tumour originating from heterotopic salivary gland tissue of the upper neck is reported. The radioactive uptake of 131I, evidenced in the neck mass in its pre-diagnostic assessment, suggested a diagnosis of cervical node involvement from a primary malignant thyroid neoplasm. A critical review of the literature on heterotopic salivary gland tissue neoplasms of the head and neck is also presented.

scholarly journals Epigenetically quantified immune cells in salivary glands of Sjögren’s syndrome patients: a novel tool that detects robust correlations of T follicular helper cells with immunopathology

Rheumatology ◽  
2019 ◽  
Vol 59 (2) ◽  
pp. 335-343 ◽  
Author(s):  
Sofie L M Blokland ◽  
Fréderique M van Vliet-Moret ◽  
Maarten R Hillen ◽  
Aridaman Pandit ◽  
Roel Goldschmeding ◽  
...  
Keyword(s):  
Salivary Gland ◽  
B Cell ◽  
Salivary Glands ◽  
Immune Cells ◽  
Cell Counting ◽  
Tissue Cell ◽  
Tfh Cells ◽  
Follicular Helper ◽  
Salivary Gland Tissue ◽  
Gland Tissue

Abstract Objective To investigate whether epigenetic cell counting represents a novel method to quantify immune cells in salivary glands of patients with different forms of Sjögren’s and sicca syndrome and to capture immunopathology and potentially aid in diagnosis. Methods DNA from frozen salivary gland tissue sections of sicca patients was used for bisulphite conversion of demethylated DNA cytosine residues, followed by cell-specific quantitative PCR to calculate cell percentages in relation to total tissue cell numbers as quantified by housekeeping gene demethylation. The percentages of epigenetically quantified cells were correlated to RNA expression of matched salivary gland tissue and histological and clinical parameters. Results The percentages of epigenetically quantified CD3, CD4, CD8, T follicular helper (Tfh) cells, FoxP3+ regulatory T cells and B cells were significantly increased in the salivary glands of patients with SS. Unsupervised clustering using these percentages identified patient subsets with an increased lymphocytic focus score and local B cell hyperactivity and classifies patients different from conventional classification criteria. In particular, Tfh cells were shown to strongly correlate with the expression of CXCL13, lymphocytic focus scores, local B cell hyperactivity and anti-SSA positivity. Conclusion Epigenetic cell counting is a promising novel tool to objectively and easily quantify immune cells in the labial salivary gland of sicca patients, with a relatively small amount of tissue needed. In view of the potential of this technique to include a huge number of (cell-specific) biomarkers, this opens up new standardized ways of salivary gland analysis with high relevance for patient classification, understanding of immunopathology and monitoring of drug responses in clinical trials.

Further Research Needed to Understand Relationship Between Tubarial Glands and Eustachian Tube Dysfunction

2021 ◽  
pp. 019459982110042
Author(s):  
Matthew J. Wu ◽  
Renata M. Knoll ◽  
Divya A. Chari ◽  
Aaron K. Remenschneider ◽  
William C. Faquin ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Salivary Glands ◽  
Clinical Significance ◽  
Eustachian Tube ◽  
Eustachian Tube Dysfunction ◽  
Future Studies ◽  
Salivary Gland Tissue ◽  
Patient Morbidity ◽  
Gland Tissue ◽  
Tube Dysfunction

The pathophysiology of eustachian tube dysfunction (ETD) remains poorly characterized, and it may result in significant patient morbidity. A recent study has identified a collection of previously unidentified salivary glands in the nasopharynx that overlay the torus tubarius. While salivary gland tissue has been described in the nasopharynx, the newly discovered salivary gland tissue has been denoted tubarial glands (TGs) and theorized to be a distinct organ. The TGs have been suggested to aid in lubrication of the oropharynx and nasopharynx. However, the exact clinical significance of TGs is unknown. Given the proximity of the TG to the eustachian tube, it is possible that the TGs may be related to the development of ETD. Future studies of the TGs and related pathophysiology may improve approaches to developing future ETD treatments.

scholarly journals USE OF 29A MICRO-RNA FOR DIAGNOSIS OF PLEOMORPHIC ADENOMAS OF SALIVARY GLANDS

2020 ◽  
Vol 20 (1) ◽  
pp. 149-154
Author(s):  
I. S. Brodetskyi ◽  
V.A. Malanchuk ◽  
V. E Dosenko
Keyword(s):  
Salivary Gland ◽  
Salivary Glands ◽  
Pleomorphic Adenoma ◽  
Quantitative Polymerase Chain Reaction ◽  
Venous Blood ◽  
Micro Rna ◽  
Salivary Gland Tissue ◽  
Pleomorphic Adenomas ◽  
Gland Tissue ◽  
Benign Tumours

Introduction. Pleomorphic adenoma is known as the most common tumour in salivary glands that makes up 60-90% of all benign tumours of the salivary glands. The modern genetic tendency towards the diagnosis of salivary gland tumours is the study of the role of microRNA molecules, and miRNA-29a in the focus of the great researchers’ interest. It is expressed in 84 % of the pleomorphic adenomas of the salivary glands. Objectives. Determination of expression of miRNA-29a in tissues of pleomorphic adenomas of the large salivary glands that adjacent to the tumour of the tissue of the salivary gland, intact tissue of the salivary gland, was out of touch with the tumour and venous blood.  Materials and methods. The study included 20 patients with benign tumours of the large salivary glands (pleomorphic adenomas). The expression of miRNA-29a was evaluated by using reverse transcription and quantitative polymerase chain reaction (qPCR) in real time. Results. The analysis of the level of miRNA-29a expression revealed that among 4 groups of indicators (tumour tissue, tissues adjacent to the tumour salivary gland tissue, intact salivary gland, which was out of touch with the tumour and venous blood) in patients with pleomorphic adenoma of the large salivary gland, the highest expression was noted in the group, where salivary gland tissue was adjacent to the salivary gland tumour (111, 93±56, 97 versus 8,12±4,4). Correlation analysis of patients with pleomorphic adenoma of the large salivary glands with different fragments of tissues samples demonstrated that the expression level of miRNA-29a differed significantly between the groups (adjacent gland - intact salivary tissue). Conclusions. A sufficiently high level of miRNA-29a expression in the tissues of pleomorphic adenoma in the large salivary glands compared with the normal (intact salivary gland tissue), 10 times as much can be used as a genetic marker for verification (identification) of this type of tumours. Studies of biopsy material from patients with pleomorphic adenoma in the large salivary glands at the genetic level (by expression of miRNAs-29a) confirm the need not only in enucleating of the tumour (partial parotidectomy), but also in performing of subtotal resection with removal of salivary gland adjacent to the tumour.

scholarly journals Heterotopic salivary gland tissue in lymph nodes of head and neck: An immunohistochemical study.

1991 ◽  
Vol 24 (6) ◽  
pp. 579-589 ◽  
Author(s):  
MASANORI SHINOHARA ◽  
TAKESHI HARADA ◽  
MASUICHIRO OKA ◽  
KAZUTO YAMADA ◽  
PRASHANTA SHRESTHA ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Lymph Nodes ◽  
Head And Neck ◽  
Immunohistochemical Study ◽  
Salivary Gland Tissue ◽  
Gland Tissue

Salivary Gland Hypofunction and Xerostomia in Head and Neck Radiation Patients

2019 ◽  
Vol 2019 (53) ◽  
Author(s):  
Siri Beier Jensen ◽  
Arjan Vissink ◽  
Kirsten H Limesand ◽  
Mary E Reyland
Keyword(s):  
Radiation Therapy ◽  
Head And Neck Cancer ◽  
Salivary Gland ◽  
Head And Neck ◽  
Neck Cancer ◽  
Radiation Injury ◽  
Salivary Gland Tissue ◽  
Gland Tissue ◽  
Salivary Gland Hypofunction ◽  
Gland Function

AbstractBackgroundThe most manifest long-term consequences of radiation therapy in the head and neck cancer patient are salivary gland hypofunction and a sensation of oral dryness (xerostomia).MethodsThis critical review addresses the consequences of radiation injury to salivary gland tissue, the clinical management of salivary gland hypofunction and xerostomia, and current and potential strategies to prevent or reduce radiation injury to salivary gland tissue or restore the function of radiation-injured salivary gland tissue.ResultsSalivary gland hypofunction and xerostomia have severe implications for oral functioning, maintenance of oral and general health, and quality of life. Significant progress has been made to spare salivary gland function chiefly due to advances in radiation techniques. Other strategies have also been developed, e.g., radioprotectors, identification and preservation/expansion of salivary stem cells by stimulation with cholinergic muscarinic agonists, and application of new lubricating or stimulatory agents, surgical transfer of submandibular glands, and acupuncture.ConclusionMany advances to manage salivary gland hypofunction and xerostomia induced by radiation therapy still only offer partial protection since they are often of short duration, lack the protective effects of saliva, or potentially have significant adverse effects. Intensity-modulated radiation therapy (IMRT), and its next step, proton therapy, have the greatest potential as a management strategy for permanently preserving salivary gland function in head and neck cancer patients.Presently, gene transfer to supplement fluid formation and stem cell transfer to increase the regenerative potential in radiation-damaged salivary glands are promising approaches for regaining function and/or regeneration of radiation-damaged salivary gland tissue.

scholarly journals Application of microRNA-34a for diagnosis of pleomorphic adenomas of salivary glands

2019 ◽  
Vol 86 (10) ◽  
pp. 67-70
Author(s):  
I. S. Brodetskyi ◽  
V. O. Malanchuk ◽  
V. E. Dosenko
Keyword(s):  
Salivary Gland ◽  
Salivary Glands ◽  
Quantitative Polymerase Chain Reaction ◽  
Venous Blood ◽  
Benign Tumors ◽  
Intact Tissue ◽  
Salivary Gland Tissue ◽  
Pleomorphic Adenomas ◽  
Gland Tissue

Objective. Determination of expression of microRNA-34a in tissues of pleomorphic adenomas of large salivary glands, adjacent to tumor salivary gland tissue, intact tissue of a salivary gland, which was not connected with the tumor, and in a venous blood as well. Materials and methods. The investigation was conducted in 20 patients, suffering benign tumors of large salivary glands (pleomorphic adenomas). Expression  was estimated, using adverse transcription and quantitative polymerase chain reaction in regime of a real time. Results. Analysis of the expression level for microRNA-34a was conducted in the tumoral tissue, adjacent to the tumor salivary gland tissue, and in intact tissue of salivary gland, which lacked a link with the tumor, the venous blood in patients, suffering pleomorphic adenomas of large salivary glands, and there was revealed, that it have appeared the highest in the salivary gland adjacent to the tumor - (1052.02 ± 367.20, comparing with the same index in the intact gland - 47.72 ± 28.93). Conclusion. Level of expression of microRNA-34a in the tissues of pleomorphic adenomas of salivary glands, which is in 11 times higher, than in norm (in intact tissue of salivary gland), may be applied as a genetic marker for verification of these tumors.

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