scholarly journals Clinical Application of Magnetic Resonance Spectroscopy in Diagnosis of Intracranial Mass Lesions

2021 ◽  
Vol 2021 ◽  
pp. 1-10
Author(s):  
Callen Kwamboka Onyambu ◽  
Mufaddal Nuruddin Wajihi ◽  
Alfred Otieno Odhiambo
Keyword(s):  
Mr Spectroscopy ◽  
Neuronal Cell ◽  
Resonance Spectroscopy ◽  
Low Grade ◽  
Mri Imaging ◽  
Imaging Diagnosis ◽  
Membrane Turnover ◽  
Intracranial Mass ◽  
Study Results ◽  
Mass Lesions

Introduction. Conventional MR imaging provides highly detailed anatomic information with unrivalled soft tissue contrast making it the mainstay in the diagnosis of suspected brain lesions. Despite this, MRI alone at times cannot answer the diagnostic questions in quite a few patients. Proton MR Spectroscopy (H-MRS) provides information on the metabolic composition within an area under interrogation. By comparing the relative concentrations of specific metabolites, the neuroradiologist can deduce critical information regarding neuronal cell density and integrity, cell membrane turnover, metabolic fuel, and possible necrosis in the region of interest. This provides a biochemical picture of the underlying pathology and thus aids in the diagnosis. Methods. This was a cross-sectional comparative study. Results. Of the 63 patients examined by MRI and MRS for intracranial mass lesions, the radiologists were able to offer a single imaging diagnosis based on MRI alone in only 15 patients (23.8%) while when MRI imaging was combined with MR spectroscopy, a single imaging diagnosis was offered in 47 patients (74.6%). This was an overall statistically significant improvement. Conclusion. MRS aided the radiologist in offering a single diagnosis in high versus low-grade gliomas, high-grade gliomas versus tuberculomas, and recurrent tumours versus radiation necrosis.

Clinical application of proton magnetic resonance spectroscopy in the diagnosis of intracranial mass lesions

2002 ◽  
Vol 44 (5) ◽  
pp. 371-381 ◽  
Author(s):  
W. Möller-Hartmann ◽  
S. Herminghaus ◽  
T. Krings ◽  
G. Marquardt ◽  
H. Lanfermann ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Magnetic Resonance Spectroscopy ◽  
Clinical Application ◽  
Proton Magnetic Resonance ◽  
Proton Magnetic Resonance Spectroscopy ◽  
Resonance Spectroscopy ◽  
Intracranial Mass ◽  
Mass Lesions

scholarly journals Using ex vivo proton magnetic resonance spectroscopy to reveal associations between biochemical and biological features of meningiomas

2010 ◽  
Vol 28 (1) ◽  
pp. E12 ◽  
Author(s):  
Wolfgang K. Pfisterer ◽  
Ronald A. Nieman ◽  
Adrienne C. Scheck ◽  
Stephen W. Coons ◽  
Robert F. Spetzler ◽  
...  
Keyword(s):  
Mr Spectroscopy ◽  
Ex Vivo ◽  
Biological Behavior ◽  
Resonance Spectroscopy ◽  
Histopathological Analysis ◽  
Low Grade ◽  
Who Grade ◽  
Absolute Concentrations ◽  
The Absolute

Object The goal in this study was to determine if proton (1H) MR spectroscopy can differentiate meningioma grade and is associated with interpretations of biological behavior; the study was performed using ex vivo high-resolution spectra indicating metabolic characteristics. Methods Sixty-eight resected tissue samples of meningiomas were examined using ex vivo 1H MR spectroscopy. Of these meningiomas, 46 were WHO Grade I, 14 were WHO Grade II, and 8 were WHO Grade III. Fifty-nine were primary meningiomas and 9 were recurrences. Invasion of adjacent tissue (dura mater, bone, venous sinus, brain) was found in 32 cases. Thirty-nine meningiomas did not rapidly recur (as defined by expansion on MR imaging within a 5-year follow-up period), whereas rapid recurrence was confirmed in 24 meningiomas, and follow-up status was unknown in 5 cases. Results The absolute concentrations of total alanine and creatine were decreased in high-grade compared with low-grade meningiomas, as was the ratio of glycine to alanine (all p < 0.05). Additionally, alanine and the glycine/alanine ratio distinguished between primary and recurrent meningiomas (all p < 0.05). Finally, the absolute concentrations of alanine and creatine, and the glycine/alanine and choline/glutamate ratios were associated with rapid recurrence (p < 0.05). Conclusions . These data indicate that meningioma tissue can be characterized by metabolic parameters that are not typically identified by histopathological analysis alone. Creatine, glycine, and alanine may be used as markers of meningioma grade, recurrence, and the likelihood of rapid recurrence. These data validate a previous study of a separate group of Grade I meningiomas.

Improved Diagnosis of Intracranial Mass Lesions by Proton MR Spectroscopy

NeuroImage ◽  
2009 ◽  
Vol 47 ◽  
pp. S69
Author(s):  
WS Lu ◽  
MH Huang ◽  
ZM Tian ◽  
X Yu ◽  
QJ Zhao ◽  
...  
Keyword(s):  
Mr Spectroscopy ◽  
Proton Mr Spectroscopy ◽  
Intracranial Mass ◽  
Mass Lesions

Use of proton magnetic resonance spectroscopy of the brain to differentiate gliomatosis cerebri from low-grade glioma

2003 ◽  
Vol 98 (2) ◽  
pp. 269-276 ◽  
Author(s):  
Damien Galanaud ◽  
Olivier Chinot ◽  
François Nicoli ◽  
Sylviane Confort-Gouny ◽  
Yann Le Fur ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Mr Spectroscopy ◽  
Proton Magnetic Resonance ◽  
Cellular Proliferation ◽  
Gliomatosis Cerebri ◽  
Resonance Spectroscopy ◽  
Low Grade ◽  
Metabolic Pattern ◽  
Content Type ◽  
Fine Print

Object. Gliomatosis cerebri (GC), a rare entity characterized by a widespread infiltration of brain by tumor, lacks objective and quantitative diagnostic criteria. Single-voxel spectroscopy and chemical shift imaging (two-dimensional proton magnetic resonance [MR] spectroscopy) were performed using both short (20- or 22-msec) and long (135-msec) echo times in nine patients suffering from GC, nine patients with low-grade gliomas (LGGs), and 25 healthy volunteers to establish the precise metabolic pattern of this uncommon brain neoplasm. Methods. The gliomatosis infiltration was characterized by markedly elevated levels of creatine—phosphocreatine (Cr) and myo-inositol (Ins), a reduced level of N-acetyl aspartate (NAA), and a moderately elevated level of choline-containing compounds (Cho). This pattern differs strikingly from LGGs, which are characterized by elevated levels of Cho and Ins, markedly reduced levels of NAA, and low-to-normal Cr concentrations. Although the distinction between GC and LGG, based on histological and MR imaging criteria, is a matter of debate, MR spectroscopy produces valuable information for the differentiation between these two entities and, hence, the choice of therapeutic strategy. It also provides new insight into the pathophysiology of GC because elevated Cr and Ins levels may be related to proliferation of glial elements or, more probably, activation of normal glia. Elevated levels of Cho reflect cellular proliferation and reduced NAA corresponds to reversible neuronal injury and/or focal invasion by the tumor process. Conclusions. Owing to the unfavorable clinical outcome associated with GC compared with that associated with LGG, the findings of this study illustrate the diagnostic and prognostic value of proton MR spectroscopy in the characterization of infiltrating gliomas.

scholarly journals Utility of 3T single-voxel proton MR spectroscopy for differentiating intracranial meningiomas from intracranial enhanced mass lesions

2021 ◽  
Vol 10 (4) ◽  
pp. 205846012110094
Author(s):  
Eiji Matsusue ◽  
Chie Inoue ◽  
Sadaharu Tabuchi ◽  
Hiroki Yoshioka ◽  
Yuichiro Nagao ◽  
...  
Keyword(s):  
Mr Spectroscopy ◽  
Roc Analysis ◽  
Threshold Value ◽  
High Accuracy ◽  
Resonance Spectroscopy ◽  
Single Voxel ◽  
Short Echo Time ◽  
Mass Lesions ◽  
Normal Controls ◽  
Metabolic Information

Background Proton magnetic resonance spectroscopy (MRS) provides structural and metabolic information that is useful for the diagnosis of meningiomas with atypical radiological appearance. However, the metabolite that should be prioritized for the diagnosis of meningiomas has not been established. Purpose To evaluate the differences between the metabolic peaks of meningiomas and other intracranial enhanced mass lesions (non-meningiomas) using MR spectroscopy in short echo time (TE) spectra and the most useful metabolic peak for discriminating between the groups. Material and Methods The study involved 9 meningiomas, 22 non-meningiomas, intracranial enhancing tumors and abscesses, and 15 normal controls. The ranking of the peak at 3.8 ppm, peak at 3.8 ppm/Creatine (Cr), β-γ Glutamine-Glutamate (bgGlx)/Cr, N-acetyl compounds (NACs)/Cr, choline (Cho)/Cr, lipid and/or lactate (Lip-Lac) at 1.3 ppm/Cr, and the presence of alanine (Ala) were derived. The metabolic peaks were compared using the Mann-Whitney U test. ROC analysis was used to determine the cut-off values for differentiating meningiomas from non-meningiomas using statistically significant metabolic peaks. Results The ranking of the peak at 3.8 ppm among all the peaks, peak at 3.8 ppm/Cr, bgGlx/Cr, Lip-Lac/Cr, and the presence of Ala discriminated meningiomas from non-meningiomas with moderate to high accuracy. The highest accuracy was 96.9% at a threshold value of 3 for the rank of the peak at 3.8 ppm. Conclusion A distinct elevated peak at 3.8 ppm, ranked among the top three highest peaks, allowed the detection of meningiomas.

Analysis of intracranial mass lesions using proton magnetic resonance spectroscopy at 1.0 T: Pictorial essay

2000 ◽  
Vol 44 (4) ◽  
pp. 385-391
Author(s):  
Daniel Birchall ◽  
Jianmin Hua ◽  
Makhan Khangure ◽  
Leonie Maddren ◽  
Swithin Song
Keyword(s):  
Magnetic Resonance ◽  
Magnetic Resonance Spectroscopy ◽  
Proton Magnetic Resonance ◽  
Proton Magnetic Resonance Spectroscopy ◽  
Resonance Spectroscopy ◽  
Intracranial Mass ◽  
Pictorial Essay ◽  
Mass Lesions

Cystic intracranial mass lesions: Possible role of in vivo MR spectroscopy in its differential diagnosis

1995 ◽  
Vol 13 (7) ◽  
pp. 1019-1029 ◽  
Author(s):  
Harish Poptani ◽  
Rakesh K. Gupta ◽  
Vijendera K. Jain ◽  
Raja Roy ◽  
Rakesh Pandey
Keyword(s):  
Differential Diagnosis ◽  
Mr Spectroscopy ◽  
Intracranial Mass ◽  
Mass Lesions

scholarly journals Poor Mitochondrial Health and Systemic Inflammation? Testing of a Classical Hypothesis

2020 ◽  
Vol 4 (Supplement_1) ◽  
pp. 126-127
Author(s):  
Marta Zampino ◽  
Luigi Ferrucci ◽  
Richard Spencer ◽  
Kenneth Fishbein ◽  
Eleanor Simonsick ◽  
...  
Keyword(s):  
Mitochondrial Function ◽  
Fat Body ◽  
Reference Group ◽  
Linear Regression Analysis ◽  
Oxidative Capacity ◽  
Conclusive Evidence ◽  
Resonance Spectroscopy ◽  
Low Grade ◽  
Severe Impairment

Abstract Chronic low-grade inflammation often occurs with aging and has been associated with negative health outcomes. Despite extensive research on the origins of “inflammaging”, the causative mechanisms remain unclear. However, a connection between poor mitochondrial health and chronic inflammation has been hypothesized, with decreasing mitochondrial function occurring with age and precipitating an increase in reactive oxygen species and other pro-inflammatory macromolecules such as mitochondrial DNA. We tested this hypothesis on a population of 619 subjects from the Baltimore Longitudinal Study of Aging, measuring muscle mitochondrial oxidative capacity in vivo by phosphorus magnetic resonance spectroscopy (P-MRS), and plasma interleukin (IL)-6, the most widely used biomarker of inflammaging. The P-MRS-derived post-exercise phosphocreatine recovery time constant tau-PCr, a measure of oxidative capacity, was expressed as a categorical variable through assignment to quintiles. Participants in the first quintile of tau-PCr (best mitochondrial function) were taken as reference and compared to the others using linear regression analysis adjusted for sex, age, lean and fat body mass, and physical activity. Those participants with the lowest oxidative capacity had significantly higher log(IL-6) levels as compared to the reference group. However, data from the other quintiles was not significantly different from the reference values. In conclusion, severe impairment of oxidative capacity is associated with increased inflammation. This study design does not provide conclusive evidence of whether increased inflammation and impaired bioenergetic recovery are both caused by underlying poor health status, or whether mitochondrial deficits lead directly to the observed inflammation; we anticipate addressing this important question with longitudinal studies.

scholarly journals Dysembryoplastic neuroepithelial tumor and oligodendroglioma: the diagnostic value of magnetic resonance spectroscopy

1998 ◽  
Vol 4 (4) ◽  
pp. E8 ◽  
Author(s):  
Eric W. Sherburn ◽  
Mark M. Bahn ◽  
Murat Gokden ◽  
Daniel L. Silbergeld ◽  
Keith M. Rich
Keyword(s):  
Magnetic Resonance ◽  
Magnetic Resonance Spectroscopy ◽  
Treatment Options ◽  
Diagnostic Value ◽  
Low Grade Glioma ◽  
Resonance Spectroscopy ◽  
Dysembryoplastic Neuroepithelial Tumor ◽  
Low Grade ◽  
Radiological Findings ◽  
Similar Treatment

Preoperative differentiation between dysembryoplastic neuroepithelial tumor (DNT) and low-grade glioma is often not possible. Dysembryoplastic neuroepithelial tumor is a recently described entity of uncertain origin; however, the diagnosis has important clinical implications. Clinical and radiological findings of DNT and low-grade glioma, especially oligodendroglioma, may be similar. Treatment options and prognosis differ significantly between these two lesions; consequently, accurate diagnosis is imperative. The authors describe two individuals who presented simultaneously at their institution: one patient with an oligodendroglioma and a second patient with DNT. The natural history, neurodiagnostic, and pathological features of each are reviewed with special emphasis on the potential utility of magnetic resonance spectroscopy in differentiating these lesions.

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