scholarly journals Spontaneous Splenic Artery Rupture as the First Symptom of Systemic Amyloidosis

2021 ◽  
Vol 2021 ◽  
pp. 1-6
Author(s):  
Øyvind Bruserud ◽  
Tor Henrik Anderson Tvedt ◽  
Aymen Bushra Ahmed ◽  
Olav Karsten Vintermyr ◽  
Tor Hervig ◽  
...  
Keyword(s):  
Splenic Artery ◽  
Splenic Rupture ◽  
Hypovolemic Shock ◽  
Plasma Cell Dyscrasia ◽  
Al Amyloidosis ◽  
Spontaneous Splenic Rupture ◽  
Chronic Infections ◽  
Transfusion Therapy ◽  
Life Threatening ◽  
Amyloid Light Chain

Spontaneous splenic rupture is a life-threatening condition leading to a rapidly progressing hypovolemic shock due to intra-abdominal blood loss, with a mortality rate of about 10%. Spontaneous splenic rupture can be caused by widely different disorders including acute and chronic infections, neoplastic disorders, and inflammatory noninfectious disorders. In this case report, we present a 67-year-old male patient with hemorrhagic shock caused by an acute bleeding from the splenic artery. The patient was massively transfused with blood products and fluids and underwent laparotomy for hemostatic control and clinical stabilization. Multiorgan involvement by amyloid light-chain amyloidosis (AL-amyloidosis) caused by plasma cell dyscrasia, specifically with infiltration of the spleen artery, was found to be the underlying cause of his life-threatening bleeding. Based on this case, we discuss the features of serious spleen bleeding, massive transfusion therapy in the intensive care setting, and AL-amyloidosis pathophysiology and treatment.

Atraumatic splenic rupture in chronic pancreatitis with successful embolization

2020 ◽  
Vol 21 (2) ◽  
pp. 58-68
Author(s):  
Anooja Abdul Salam ◽  
Ben Pearch ◽  
Lisa Sorger
Keyword(s):  
Chronic Pancreatitis ◽  
Splenic Artery ◽  
Splenic Rupture ◽  
Early Recognition ◽  
Hypovolemic Shock ◽  
Artery Embolization ◽  
Splenic Artery Embolization ◽  
Threatening Condition ◽  
Life Threatening ◽  
Atraumatic Splenic Rupture

Atraumatic splenic rupture is uncommon but it is a life threatening condition because of hypovolemic shock. Early recognition and treatment are the keys to asuccessful outcome. We report a case of atraumatic splenic rupture secondary to chronic pancreatitis treated successfully by splenic artery embolization.

scholarly journals Atraumatic splenic rupture in chronic pancreatitis with successful embolization

2020 ◽  
pp. 58-68
Author(s):  
Anooja Abdul Salam ◽  
Ben Pearch ◽  
Lisa Sorger
Keyword(s):  
Chronic Pancreatitis ◽  
Splenic Artery ◽  
Splenic Rupture ◽  
Early Recognition ◽  
Hypovolemic Shock ◽  
Artery Embolization ◽  
Splenic Artery Embolization ◽  
Threatening Condition ◽  
Life Threatening ◽  
Atraumatic Splenic Rupture

Atraumatic splenic rupture is uncommon but it is a life threatening condition because of hypovolemic shock. Early recognition and treatment are the keys to asuccessful outcome. We report a case of atraumatic splenic rupture secondary to chronic pancreatitis treated successfully by splenic artery embolization.

scholarly journals Hemorrhagic Shock as a Sequela of Splenic Rupture in a Patient with Infectious Mononucleosis: Focus on the Potential Role of Salicylates

2012 ◽  
Vol 2012 ◽  
pp. 1-3 ◽  
Author(s):  
Konstantinos Bouliaris ◽  
Dimos Karangelis ◽  
Marios Daskalopoulos ◽  
Konstantinos Spanos ◽  
Michael Fanariotis ◽  
...  
Keyword(s):  
Hemorrhagic Shock ◽  
Infectious Mononucleosis ◽  
Potential Role ◽  
Splenic Rupture ◽  
Emergency Laparotomy ◽  
Hemorrhagic Complication ◽  
Spontaneous Splenic Rupture ◽  
Predisposing Factor ◽  
Life Threatening

Despite the fact that the vast majority of splenic ruptures are traumatic, infectious mononucleosis has been incriminated as a major predisposing factor that affects the integrity of the spleen, thus causing atraumatic ruptures and life-threatening hemorrhages. Herein we present a case of a 23-year-old Caucasian male who underwent an emergency laparotomy for acute abdomen and hemorrhagic shock, caused by spontaneous splenic rupture secondary to infectious mononucleosis. The potential role of salicylates in the development of a hemorrhagic complication in a patient with infectious mononucleosis is discussed.

scholarly journals Successful Nonoperative Management of Spontaneous Splenic Hematoma and Hemoperitoneum due to CMV Infection

2012 ◽  
Vol 2012 ◽  
pp. 1-4 ◽  
Author(s):  
Georgios Lianos ◽  
Eleftheria Ignatiadou ◽  
Christina Bali ◽  
Haralampos Harissis ◽  
Christos Katsios
Keyword(s):  
Case Report ◽  
Rare Case ◽  
Splenic Rupture ◽  
Nonoperative Management ◽  
Spontaneous Splenic Rupture ◽  
Cmv Infection ◽  
Life Threatening ◽  
Splenic Hematoma ◽  
Immunocompetent Adults ◽  
Operating Surgeon

Introduction. Spontaneous splenic hematoma or splenic rupture due to CMV infection in immunocompetent adults is rare and life-threatening.Case Report. Herein we report a rare case of spontaneous splenic hematoma and hemoperitoneum due to CMV infection in a 23-year-old Caucasian male in whom conservative management was successful.Conclusion. Spontaneous splenic hematoma and spontaneous splenic rupture are extremely rare conditions during primary CMV infection. Though rare, they must be always considered by the operating surgeon, because any misinterpretation may result in unfavorable outcomes.

scholarly journals Spontaneous Splenic Rupture and Rituximab-Induced Acute Thrombocytopenia in a Patient with High-Risk Mantle Cell Lymphoma

2019 ◽  
Vol 2019 ◽  
pp. 1-4 ◽  
Author(s):  
Jared Williams ◽  
Shingi Chiruka
Keyword(s):  
High Risk ◽  
Mantle Cell Lymphoma ◽  
Rare Case ◽  
Splenic Rupture ◽  
Cell Lymphoma ◽  
Case Reports ◽  
Spontaneous Splenic Rupture ◽  
Rare Type ◽  
Mantle Cell ◽  
Life Threatening

Mantle cell lymphoma is a relatively rare type of mature B-cell non-Hodgkin’s lymphoma with an incidence of approximately 8 cases per million persons per year. In patients with mantle cell lymphoma, there are rare case reports of the potentially life-threatening consequences of splenic rupture and rituximab-induced acute thrombocytopenia (RIAT) occurring separately, but there are no reports of these occurring in the same patient. Whilst rare, they are important to be aware of as early detection may prevent fatal outcomes.

Acquired factor X deficiency in patients with amyloid light-chain amyloidosis: incidence, bleeding manifestations, and response to high-dose chemotherapy

Blood ◽  
2001 ◽  
Vol 97 (6) ◽  
pp. 1885-1887 ◽  
Author(s):  
Elie B. Choufani ◽  
Vaishali Sanchorawala ◽  
Timothy Ernst ◽  
Karen Quillen ◽  
Martha Skinner ◽  
...  
Keyword(s):  
Light Chain ◽  
Medical Center ◽  
Bleeding Complications ◽  
Plasma Cell Dyscrasia ◽  
High Dose ◽  
Al Amyloidosis ◽  
Related Factor ◽  
Factor X ◽  
Factor X Deficiency ◽  
Amyloid Light Chain

Acquired deficiency of factor X occurs in patients with systemic amyloid light-chain (AL) amyloidosis, presumably due to adsorption of factor X to amyloid fibrils. Of 368 consecutive patients with systemic AL amyloidosis evaluated at Boston Medical Center, 32 patients (8.7%) had factor X levels below 50% of normal. Eighteen of these patients (56%) had bleeding complications, which were more frequent and severe in the 12 patients below 25% of normal; 2 episodes were fatal. Ten factor X–deficient patients received high-dose melphalan chemotherapy followed by autologous stem cell transplantation. Of 7 patients alive 1 year after treatment, 4 had a complete hematologic response, and all 4 experienced improvement in their factor X levels. One of 2 additional patients with partial hematologic responses had improvement in factor X. Thus, aggressive treatment of the underlying plasma cell dyscrasia in AL amyloidosis can lead to the amelioration of amyloid-related factor X deficiency.

scholarly journals It’s never too late- spontaneous rupture of spleen and life-threatening hypovolemic shock in a patient recuperating from legionnaire’s disease

2021 ◽  
Vol 7 (2) ◽  
Keyword(s):  
Splenic Rupture ◽  
Hypovolemic Shock ◽  
Traumatic Rupture ◽  
Quadrant Pain ◽  
Legionella Pneumonia ◽  
Threatening Condition ◽  
Life Threatening ◽  
Legionnaires Disease ◽  
Low Threshold ◽  
Rupture Of The Spleen

Spontaneous non-traumatic rupture of the spleen in the setting of Legionnaires’ disease is very uncommon but a life-threatening condition. The splenic rupture can present within a few days after symptom onset with significant hypotension with drop in haemoglobin along with left side upper quadrant pain. Most of the cases described in the previous literature have presented within 0-11 (mean 4) days of the pneumonia but this case we are reporting presented after 3 weeks after being treated with Legionella pneumonia. The case also highlights an atypical presentation and emphasises the need to maintain a low threshold for diagnosis especially in resource constrained setting so that patient can be transferred at the earliest to a centre where appropriate corrective measures including surgery can be safely undertaken. Keywords: splenic rupture, pneumonia, hypovolemic shock

scholarly journals Spontaneous splenic rupture: A rare life-threatening condition; Diagnosed early and managed successfully

2013 ◽  
Vol 14 ◽  
pp. 13-15 ◽  
Author(s):  
Helen Weaver ◽  
Vishal Kumar ◽  
Kate Spencer ◽  
Mohamed Maatouk ◽  
Sohail Malik
Keyword(s):  
Splenic Rupture ◽  
Spontaneous Splenic Rupture ◽  
Threatening Condition ◽  
Life Threatening
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