The Effect of Cromolyn Sodium and Nedocromil Sodium Administered by A pressurized Aerosol with A spacer Device on Exercise-Induced Asthma in Children

To compare the effectiveness of cromolyn sodium (CS) (10 mg) and nedocromil sodium (NS) (4 mg) administered by a metered dose inhaler (MDI) with a spacer device in preventing exercise-induced asthma (EIA), eight asthmatic children with EIA were studied in a randomized double-blind, cross-over, placebo-controlled study, CS and NS provided significant, comparable protection from EIA and both were better than placebo. We conclude that CS and NS administered by a pressurized aerosol with a spacer device provide equal protection against EIA in children.

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A randomized, 12-week, double-blind, placebo-controlled study comparing formoterol dry powder inhaler with albuterol metered-dose inhaler

Annals of Allergy Asthma & Immunology ◽

10.1016/s1081-1206(10)62351-4 ◽

2001 ◽

Vol 86 (1) ◽

pp. 19-27 ◽

Cited By ~ 50

Author(s):

George Bensch ◽

Robert J Lapidus ◽

Bernard E Levine ◽

William Lumry ◽

Ümit Yegen ◽

...

Keyword(s):

Dry Powder Inhaler ◽

Controlled Study ◽

Dose Inhaler ◽

Metered Dose Inhaler ◽

Dry Powder ◽

Double Blind ◽

Double Blind Placebo ◽

Metered Dose

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Bronchodilating effects of a new beclometasone dipropionate plus formoterol fumarate formulation via pressurized metered-dose inhaler in asthmatic children: a double-blind, randomized, cross-over clinical study

European Journal of Pediatrics ◽

10.1007/s00431-020-03888-x ◽

2021 ◽

Author(s):

Petr Pohunek ◽

Guido Varoli ◽

Yuriy Reznichenko ◽

Svetlana Mokia-Serbina ◽

Jerzy Brzostek ◽

...

Keyword(s):

Clinical Study ◽

Dose Inhaler ◽

Metered Dose Inhaler ◽

Double Blind ◽

Asthmatic Children ◽

Metered Dose ◽

Pressurized Metered Dose Inhaler ◽

Formoterol Fumarate

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Inhaled Terbutaline Administered via a Spacer Fully Prevents Exercise-Induced Asthma in Young Asthmatic Subjects: A Double-Blind, Randomized, Placebo-Controlled Study

Journal of International Medical Research ◽

10.1177/030006058901700602 ◽

1989 ◽

Vol 17 (6) ◽

pp. 506-513 ◽

Cited By ~ 3

Author(s):

A.T. Dinh Xuan ◽

C. Lebeau ◽

R. Roche ◽

A. Ferriere ◽

M. Chaussain

Keyword(s):

Room Temperature ◽

Work Load ◽

Cycle Ergometer ◽

Forced Expiratory Volume ◽

Controlled Study ◽

Adrenergic Agonist ◽

Double Blind ◽

Asthmatic Children ◽

Exercise Induced ◽

Age Range

The effects of inhaled terbutaline, a β2-adrenergic agonist, administered via a 750-ml spacer device were studied in young asthmatic subjects with exercise-induced asthma. A double-blind, randomized, placebo-controlled study of the effects of inhaled 0.5 mg terbutaline and placebo was conducted in 10 asthmatic children (age range 6–16 years) with documented exercise-induced asthma. Forced expiratory volume in 1 s (FEV1) was measured at baseline, 15 min after inhaling terbutaline or placebo, and at intervals up to 60 min after exercising. Subjects exercised using a cycle ergometer for 5 min at a submaximal, constant work-load while breathing dry air at room temperature. Terbutaline induced bronchodilation at rest in all subject and fully prevented exercise-induced asthma in nine out of the 10 subjects; the exercise-induced fall in FEV1 was markedly reduced in the remaining subject. It is concluded that exercise-induced asthma can be inhibited by pretreatment with inhaled terbutaline, administered via a spacer, in a majority of young asthmatics.

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Comparison of the Effects of Inhaled SCH 1000 and Fenoterol on Exercise-Induced Bronchospasm in Children

PEDIATRICS ◽

10.1542/peds.66.1.109 ◽

1980 ◽

Vol 66 (1) ◽

pp. 109-114

Author(s):

R. Yeung ◽

G. M. Nolan ◽

H. Levison

Keyword(s):

Side Effects ◽

Pulmonary Function ◽

Controlled Study ◽

Anticholinergic Drugs ◽

Base Line ◽

Anticholinergic Agent ◽

Asthmatic Children ◽

Before And After ◽

Exercise Induced ◽

Better Than

The effect of 40 µg of SCH 1000 (ipratropium bromide, an anticholinergic agent) on bronchodilation and suppression of exercise-induced bronchospasm (EIB) was compared with 400 µg of fenoterol and a placebo in a single-blind controlled study. Twenty-seven randomly selected asthmatic children performed a standardized treadmill exercise challenge and the 17 children who were shown to have EIB continued in the study. Pulmonary function was evaluated before and after drug administration and exercise. When individual results were analyzed and grouped according to the responsiveness of EIB to the drugs, two patterns emerged: (1) the EIB was more severe in those (6/17) children who did not respond to either drug than in the rest of the children; (2) the resting pulmonary function was significantly better in the children (4/17) who responded to both drugs than in those (7/17) who responded to fenoterol alone. In conclusion SCH 1000 was shown to be an effective bronchodilator comparable to, but no better than, fenoterol. It had minimal side effects. As an EIB inhibitor it depended on relatively normal base line pulmonary function and only a moderate deterioration following exercise, whereas fenoterol depended on the exercise response alone. Although anticholinergic drugs are not very extensively used, SCH 1000 may be useful in some patients where the β2 adrenergic drugs cause significant side effects or are contraindicated.

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