AbstractWe study the following fractional Yamabe-type equation:\left\{\begin{aligned} \displaystyle A_{s}u&\displaystyle=u^{\frac{n+2s}{n-2s}% },\\ \displaystyle u&\displaystyle>0&&\displaystyle\text{in }\Omega,\\ \displaystyle u&\displaystyle=0&&\displaystyle\text{on }\partial\Omega,\end{% aligned}\right.Here Ω is a regular bounded domain of{\mathbb{R}^{n}},{n\geq 2}, and{A_{s}},{s\in(0,1)}, represents the fractional Laplacian operator{(-\Delta)^{s}}in Ω with zero Dirichlet boundary condition. We investigate the effect of the topology of Ω on the existence of solutions. Our result can be seen as the fractional counterpart of the Bahri–Coron theorem [3].