Inhibition of Integrin-Linked Kinase by a Selective Small Molecule Inhibitor, QLT0254, Inhibits the PI3K/PKB/mTOR, Stat3, and FKHR Pathways and Tumor Growth, and Enhances Gemcitabine-Induced Apoptosis in Human Orthotopic Primary Pancreatic Cancer Xenografts

Molecule Inhibitor ◽

Integrin Linked Kinase ◽

Induced Apoptosis

Critical role of prostate apoptosis response-4 in determining the sensitivity of pancreatic cancer cells to small-molecule inhibitor-induced apoptosis

Molecular Cancer Therapeutics ◽

10.1158/1535-7163.mct-08-0438 ◽

2008 ◽

Vol 7 (9) ◽

pp. 2884-2893 ◽

Cited By ~ 28

Author(s):

A. S. Azmi ◽

Z. Wang ◽

R. Burikhanov ◽

V. M. Rangnekar ◽

G. Wang ◽

...

Keyword(s):

Pancreatic Cancer ◽

Cancer Cells ◽

Small Molecule ◽

Critical Role ◽

Pancreatic Cancer Cells ◽

Molecule Inhibitor ◽

Induced Apoptosis

QLT0267, a small molecule inhibitor targeting integrin-linked kinase (ILK), and docetaxel can combine to produce synergistic interactions linked to enhanced cytotoxicity, reductions in P-AKT levels, altered F-actin architecture and improved treatment outcomes in an orthotopic breast cancer model

Breast Cancer Research ◽

10.1186/bcr2252 ◽

2009 ◽

Vol 11 (3) ◽

Cited By ~ 43

Author(s):

Jessica Kalra ◽

Corinna Warburton ◽

Karen Fang ◽

Lincoln Edwards ◽

Tim Daynard ◽

...

Keyword(s):

Breast Cancer ◽

Treatment Outcomes ◽

Small Molecule ◽

Cancer Model ◽

Synergistic Interactions ◽

Molecule Inhibitor ◽

Breast Cancer Model ◽

Integrin Linked Kinase

A Novel Small-Molecule Inhibitor of Protein Kinase D Blocks Pancreatic Cancer Growth In vitro and In vivo

Molecular Cancer Therapeutics ◽

10.1158/1535-7163.mct-09-1145 ◽

2010 ◽

Vol 9 (5) ◽

pp. 1136-1146 ◽

Cited By ~ 95

Author(s):

Kuzhuvelil B. Harikumar ◽

Ajaikumar B. Kunnumakkara ◽

Nobuo Ochi ◽

Zhimin Tong ◽

Amit Deorukhkar ◽

...

Keyword(s):

Pancreatic Cancer ◽

Protein Kinase ◽

Small Molecule ◽

Cancer Growth ◽

Protein Kinase D ◽

Small-molecule inhibitor of AF9/ENL-DOT1L/AF4/AFF4 interactions suppresses malignant gene expression and tumor growth

Theranostics ◽

10.7150/thno.56737 ◽

2021 ◽

Vol 11 (17) ◽

pp. 8172-8184

Author(s):

Fangrui Wu ◽

Shenyou Nie ◽

Yuan Yao ◽

Tong Huo ◽

Xin Li ◽

...

Keyword(s):

Gene Expression ◽

Tumor Growth ◽

Small Molecule ◽

Inhibition of Tumor Growth, Angiogenesis, and Tumor Cell Proliferation by a Small Molecule Inhibitor of c-Jun N-terminal Kinase

Journal of Pharmacology and Experimental Therapeutics ◽

10.1124/jpet.104.078873 ◽

2004 ◽

Vol 313 (1) ◽

pp. 325-332 ◽

Cited By ~ 46

Author(s):

Bruce W. Ennis ◽

Kimberly E. Fultz ◽

Kent A. Smith ◽

John K. Westwick ◽

Dan Zhu ◽

...

Keyword(s):

Cell Proliferation ◽

Tumor Growth ◽

Tumor Cell ◽

Small Molecule ◽

Tumor Cell Proliferation ◽

Molecule Inhibitor ◽

Inhibition Of Tumor Growth

Abstract 2740: Antitumor activity of BMS-754807, a small molecule inhibitor of insulin-like growth factor-1 receptor / insulin receptor, in combination with gemcitabine in pancreatic cancer

10.1158/1538-7445.am2012-2740 ◽

2012 ◽

Author(s):

Niranjan Awasthi ◽

Changhua Zhang ◽

Margaret A. Schwarz ◽

Roderich E. Schwarz

Keyword(s):

Pancreatic Cancer ◽

Growth Factor ◽

Antitumor Activity ◽

Insulin Receptor ◽

Small Molecule ◽

Insulin Like Growth Factor ◽

Abstract 3491: Enhancing nab-paclitaxel antitumor activity through addition of BMS-754807, a small-molecule inhibitor of IGF-1R/IR, in experimental pancreatic cancer

10.1158/1538-7445.am2015-3491 ◽

2015 ◽

Author(s):

Niranjan Awasthi ◽

Margaret A. Schwarz ◽

Roderich E. Schwarz

Keyword(s):

Pancreatic Cancer ◽

Antitumor Activity ◽

Small Molecule ◽

Molecule Inhibitor ◽

Experimental Pancreatic Cancer

A covalent small molecule inhibitor of glutamate-oxaloacetate transaminase 1 impairs pancreatic cancer growth

Biochemical and Biophysical Research Communications ◽

10.1016/j.bbrc.2019.11.130 ◽

2020 ◽

Vol 522 (3) ◽

pp. 633-638 ◽

Cited By ~ 8

Author(s):

Tomohiro Yoshida ◽

Shingo Yamasaki ◽

Osamu Kaneko ◽

Naofumi Taoka ◽

Yusuke Tomimoto ◽

...

Keyword(s):

Pancreatic Cancer ◽

Small Molecule ◽

Cancer Growth ◽

Glutamate Oxaloacetate Transaminase ◽

Su1153 NOVEL SMALL MOLECULE INHIBITOR OF ASPARTATE-β-HYDROXYLASE INHIBITS TUMOR GROWTH IN PANCREATIC DUCTAL ADENOCARCINOMA

Gastroenterology ◽

10.1016/s0016-5085(20)32002-3 ◽

2020 ◽

Vol 158 (6) ◽

pp. S-525

Author(s):

Katherine Y. Fan ◽

Xuewei Bai ◽

Yanmei Zhou ◽

Jack R. Wands

Keyword(s):

Tumor Growth ◽

Pancreatic Ductal Adenocarcinoma ◽

Small Molecule ◽

Ductal Adenocarcinoma ◽

TW-37, A NONPEPTIDIC SMALL-MOLECULE INHIBITOR OF BCL-2, INHIBITS INVASION AND ANGIOGENESIS IN PANCREATIC CANCER

Pancreas ◽

10.1097/01.mpa.0000297810.50526.d6 ◽

2007 ◽

Vol 35 (4) ◽

pp. 434-435

Author(s):

Z. Wang ◽

W. Song ◽

A. Aboukameel ◽

G. Wang ◽

S. Wang ◽

...

Keyword(s):

Pancreatic Cancer ◽

Small Molecule ◽