scholarly journals Gastrointestinal Tract Dysbiosis Enhances Distal Tumor Progression through Suppression of Leukocyte Trafficking

2019 ◽  
Vol 79 (23) ◽  
pp. 5999-6009 ◽  
Author(s):  
Samir V. Jenkins ◽  
Michael S. Robeson ◽  
Robert J. Griffin ◽  
Charles M. Quick ◽  
Eric R. Siegel ◽  
...  
Cells ◽  
2019 ◽  
Vol 8 (6) ◽  
pp. 613 ◽  
Author(s):  
Reynders ◽  
Abboud ◽  
Baragli ◽  
Noman ◽  
Rogister ◽  
...  

First thought to orchestrate exclusively leukocyte trafficking, chemokines are now acknowledged for their multiple roles in the regulation of cell proliferation, differentiation, and survival. Dysregulation of their normal functions contributes to various pathologies, including inflammatory diseases and cancer. The two chemokine receptor 3 variants CXCR3-A and CXCR3-B, together with their cognate chemokines (CXCL11, CXCL10, CXCL9, CXCL4, and CXCL4L1), are involved in the control but also in the development of many tumors. CXCR3-A drives the infiltration of leukocytes to the tumor bed to modulate tumor progression (paracrine axis). Conversely, tumor-driven changes in the expression of the CXCR3 variants and their ligands promote cancer progression (autocrine axis). This review summarizes the anti- and pro-tumoral activities of the CXCR3 variants and their associated chemokines with a focus on the understanding of their distinct biological roles in the tumor microenvironment.


2020 ◽  
Author(s):  
B Uhl ◽  
C Braun ◽  
F Haring ◽  
J Dominik ◽  
L Mittmann ◽  
...  

2015 ◽  
Vol 47 (2) ◽  
pp. 142-150 ◽  
Author(s):  
Haruna Takeda ◽  
Zhubo Wei ◽  
Hideto Koso ◽  
Alistair G Rust ◽  
Christopher Chin Kuan Yew ◽  
...  

2021 ◽  
Vol 11 (4) ◽  
pp. 79-84
Author(s):  
Ivan Reva ◽  
Tatsuo Yamamoto ◽  
Dmitriy Zvyagintsev ◽  
Iliya Kalinin ◽  
Stanislav Ichenko ◽  
...  

A study of the diagnostic value of tissue eosinophil infiltration in the structure of polyps of the human gastrointestinal tract and surrounding tissues was carried out. We investigated intestinal biopsies from 189 patients aged 40–90 years with polyps, cancer, metastases. This retrospective study allows us to note the possibility of using eosinophils in the development of criteria for early malignancy and a promising outcome of neoplasms in the mucous membrane. Eosinophils are important players in intercellular interactions within the polyp structure and the tissues around it. The complete absence of eosinophils in the tissue of malignant polyps indicates the malignancy of the neoplasm. We revealed relationship between apoptosis and eosinophilic infiltration; both of them affect the outcome and prognosis of polyp development. Apoptosis induction by eosinophils and programmed cambium necrosis in tumor progression need to be further researched.


2021 ◽  
Author(s):  
B Uhl ◽  
C Braun ◽  
F Haring ◽  
J Dominik ◽  
B Smiljanov ◽  
...  

1985 ◽  
Vol 6 (2) ◽  
pp. 52-58 ◽  
Author(s):  
Susan T. Bagley

AbstractThe genus Klebsiella is seemingly ubiquitous in terms of its habitat associations. Klebsiella is a common opportunistic pathogen for humans and other animals, as well as being resident or transient flora (particularly in the gastrointestinal tract). Other habitats include sewage, drinking water, soils, surface waters, industrial effluents, and vegetation. Until recently, almost all these Klebsiella have been identified as one species, ie, K. pneumoniae. However, phenotypic and genotypic studies have shown that “K. pneumoniae” actually consists of at least four species, all with distinct characteristics and habitats. General habitat associations of Klebsiella species are as follows: K. pneumoniae—humans, animals, sewage, and polluted waters and soils; K. oxytoca—frequent association with most habitats; K. terrigena— unpolluted surface waters and soils, drinking water, and vegetation; K. planticola—sewage, polluted surface waters, soils, and vegetation; and K. ozaenae/K. rhinoscleromatis—infrequently detected (primarily with humans).


2001 ◽  
Vol 120 (5) ◽  
pp. A695-A695
Author(s):  
M RUEHL ◽  
I SCHOENFELDER ◽  
R FARNDALE ◽  
G KNIGHT ◽  
R SOMASUNDARAM ◽  
...  

2001 ◽  
Vol 120 (5) ◽  
pp. A573-A573
Author(s):  
J SHODA ◽  
T ASANO ◽  
T KAWAMOTO ◽  
Y MATSUZAKI ◽  
N TANAKA ◽  
...  

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