Abstract P3-06-28: Use of the MiCK drug-induced apoptosis assay improves clinical outcomes in recurrent breast cancer (BRCA)

2012 ◽  
Author(s):  
L Bosserman ◽  
K Rogers ◽  
D Davidson ◽  
P Whitworth ◽  
M Karimi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Clinical Outcomes ◽  
Recurrent Breast Cancer ◽  
Drug Induced ◽  
Apoptosis Assay ◽  
Recurrent Breast ◽  
Induced Apoptosis

scholarly journals Benign dermoscopic parallel ridge pattern in plantar hyperpigmentation due to capecitabine

2015 ◽  
pp. 79-81
Author(s):  
Linda Tognetti ◽  
Michele Fimiani ◽  
Pietro Rubegni
Keyword(s):  
Breast Cancer ◽  
Adjuvant Chemotherapy ◽  
Outpatient Clinic ◽  
Recurrent Breast Cancer ◽  
Eccrine Gland ◽  
Drug Induced ◽  
The Past ◽  
Ridge Pattern ◽  
History Of ◽  
Recurrent Breast

We report the case of a 37-year-old woman (phototype II) who presented at our outpatient clinic with a two-month history of hyperpigmented plantar macules. Medical history revealed that the patient had taken capecitabine in the past three months as adjuvant chemotherapy for recurrent breast cancer. Dermoscopic examination of the plantar macules showed parallel ridge pattern with pigmentation in the furrows without obliteration of eccrine gland apertures. Besides in acral melanoma, parallel ridge pattern can also be observed in benign plantar lesions, such as congenital or acquired acral nevi, subcorneal hemorrhage, dye-related pigmentation and drug-induced hyperpigmentation, especially in patients with phototypes III-VI. The few reported cases of capecitabine-induced hyperpigmentation have been associated with hand and foot syndrome in patients with phototypes IV-V and palmar as well as plantar involvement.

scholarly journals Application of a Drug-Induced Apoptosis Assay to Identify Treatment Strategies in Recurrent or Metastatic Breast Cancer

PLoS ONE ◽  
2015 ◽  
Vol 10 (5) ◽  
pp. e0122609 ◽  
Author(s):  
Linda Bosserman ◽  
Karl Rogers ◽  
Carl Willis ◽  
Dirk Davidson ◽  
Pat Whitworth ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Metastatic Breast Cancer ◽  
Treatment Strategies ◽  
Metastatic Breast ◽  
Drug Induced ◽  
Apoptosis Assay ◽  
Induced Apoptosis

ER, PR & HER2 Receptor status in recurrent breast cancer: Its relation to age & time of recurrence

2020 ◽  
Vol 22 (1) ◽  
pp. 16-20
Author(s):  
Abu Khaled Muhammad Iqbal ◽  
Nasima Akhter ◽  
Hasan Shahrear Ahmed ◽  
Md Rassell ◽  
AMM Yahia ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Treatment Approach ◽  
Recurrent Breast Cancer ◽  
Breast Cancer Patients ◽  
Her2 Receptor ◽  
Younger Patients ◽  
Receptor Status ◽  
Increased Risk ◽  
Neoplastic Lesions ◽  
Recurrent Breast

Background: Malignant neoplastic lesions of the breast are one of the main causes of cancer death among women. In tumor cells the expression status of Estrogen receptor (ER), progesterone receptor (PR), and c-ERBB2 (HER2/neu) are therapeutically and prognostically important markers affecting the treatment approach, management and prognosis of breast carcinoma. Objective: To explore the relation of receptor status in recurrent breast cancer to age and time of recurrence. Methods: This study was conducted in National Institute of Cancer Research and Hospital (NICRH) and included 81 female patients between 20 to 75 years with recurrent breast cancer. Detection of receptor status of ER +ve/-ve, PR +ve/-ve, Her-2+ve/-ve was based on the immunohistochemistry staining of tissue samples of malignant neoplastic lesions prepared from tissue biopsies of patients with recurrent breast cancer. All the information were recorded through the pre-structured data collection sheet and analyzed. Results: This study showed that most of the recurrent breast cancer patients were Triple negative breast cancer (TNBC) (39.5%) and among them most of them were younger patients. Younger patients with TNBC had increased risk of recurrence. Most of the recurrence occurred within 1-2 years. Conclusion: It can be concluded that the assessment of the expression of these biornarkers in recurrent tumors provides reliable information for the treatment approach of locoregional tumors. Journal of Surgical Sciences (2018) Vol. 22 (1): 16-20

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