scholarly journals A Novel Engineered Small Protein for Positron Emission Tomography Imaging of Human Programmed Death Ligand-1: Validation in Mouse Models and Human Cancer Tissues

2018 ◽  
Vol 25 (6) ◽  
pp. 1774-1785 ◽  
Author(s):  
Arutselvan Natarajan ◽  
Chirag B. Patel ◽  
Sindhuja Ramakrishnan ◽  
Paramjyot S. Panesar ◽  
Steven R. Long ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Mouse Models ◽  
Human Cancer ◽  
Positron Emission Tomography Imaging ◽  
Emission Tomography ◽  
Programmed Death Ligand 1 ◽  
Tomography Imaging ◽  
Positron Emission ◽  
Programmed Death ◽  
Cancer Tissues

A desferrioxamine B squaramide ester for the incorporation of zirconium-89 into antibodies

2016 ◽  
Vol 52 (80) ◽  
pp. 11889-11892 ◽  
Author(s):  
Stacey E. Rudd ◽  
Peter Roselt ◽  
Carleen Cullinane ◽  
Rodney J. Hicks ◽  
Paul S. Donnelly
Keyword(s):  
Breast Cancer ◽  
Positron Emission Tomography ◽  
Mouse Models ◽  
Positron Emission Tomography Imaging ◽  
Emission Tomography ◽  
Tomography Imaging ◽  
Ester Derivative ◽  
Desferrioxamine B ◽  
Positron Emission

A squaramide ester derivative of desferrioxamine B is used to attach zirconium-89 to the antibody trastuzumab and the new conjugate is used for positron emission tomography imaging in mouse models of breast cancer.

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