Blocking heat shock protein-90 inhibits the invasive properties and hepatic growth of human colon cancer cells and improves the efficacy of oxaliplatin in p53-deficient colon cancer tumors in vivo

2007 ◽  
Vol 6 (11) ◽  
pp. 2868-2878 ◽  
Author(s):  
Christian Moser ◽  
Sven A. Lang ◽  
Silvia Kainz ◽  
Andreas Gaumann ◽  
Stefan Fichtner-Feigl ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Heat Shock ◽  
Heat Shock Protein ◽  
Cancer Cells ◽  
Heat Shock Protein 90 ◽  
Human Colon ◽  
Colon Cancer Cells ◽  
Human Colon Cancer ◽  
Human Colon Cancer Cells

scholarly journals The Heat Shock Protein 70 is a Novel Target for Nobiletin in Human Colon Cancer Cells

2016 ◽  
Vol 30 (S1) ◽  
Author(s):  
Zili Gao ◽  
Jinkai Zheng ◽  
Xian Wu ◽  
Kalina Dimova ◽  
Stylianos Scordilis ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Heat Shock ◽  
Heat Shock Protein ◽  
Cancer Cells ◽  
Heat Shock Protein 70 ◽  
Human Colon ◽  
Colon Cancer Cells ◽  
Human Colon Cancer ◽  
Novel Target ◽  
Human Colon Cancer Cells

Inhibition of Heat-shock Protein 27 Reduces 5-Fluorouracil-acquired Resistance in Human Colon Cancer Cells

2021 ◽  
Vol 41 (3) ◽  
pp. 1283-1290
Author(s):  
YUSUKE ASADA ◽  
MASASHI TSURUTA ◽  
KOJI OKABAYASHI ◽  
KOHEI SHIGETA ◽  
TAKASHI ISHIDA ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Heat Shock ◽  
Heat Shock Protein ◽  
Cancer Cells ◽  
Acquired Resistance ◽  
Human Colon ◽  
Heat Shock Protein 27 ◽  
Colon Cancer Cells ◽  
Human Colon Cancer ◽  
Human Colon Cancer Cells

scholarly journals In Vitro and in Vivo antitumor activity and the mechanism of siphonodictyal B in human colon cancer cells

2019 ◽  
Vol 8 (12) ◽  
pp. 5662-5672 ◽  
Author(s):  
Sonoko Chikamatsu ◽  
Ken Saijo ◽  
Hiroo Imai ◽  
Koichi Narita ◽  
Yoshifumi Kawamura ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Antitumor Activity ◽  
Cancer Cells ◽  
Human Colon ◽  
Colon Cancer Cells ◽  
Human Colon Cancer ◽  
In Vivo Antitumor Activity ◽  
Human Colon Cancer Cells

scholarly journals Identification of a thymidylate synthase ribonucleoprotein complex in human colon cancer cells.

1994 ◽  
Vol 14 (1) ◽  
pp. 207-213 ◽  
Author(s):  
E Chu ◽  
D M Voeller ◽  
K L Jones ◽  
T Takechi ◽  
G F Maley ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cancer Cells ◽  
Thymidylate Synthase ◽  
Translational Regulation ◽  
Direct Interaction ◽  
Human Colon ◽  
Colon Cancer Cells ◽  
Human Colon Cancer ◽  
Human Colon Cancer Cells

Translation of thymidylate synthase (TS) mRNA is controlled by its own protein product, TS, in an autoregulatory manner. Direct binding of TS protein to two different cis-acting elements on the TS mRNA is associated with this translational regulation. In this study, an immunoprecipitation-reverse transcription-PCR technique was used to identify a TS ribonucleoprotein (RNP) complex in cultured human colon cancer cells. Using antibodies specific for TS protein, we show that TS is complexed in vivo with its own TS RNA. Furthermore, evidence demonstrating a direct interaction between the mRNA of the nuclear oncogene c-myc and TS protein is presented.

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