Abstract A102: First‐in‐man, first‐in‐class, pharmacokinetic and pharmacodynamic phase I clinical trial of a human monoclonal antibody CNTO888 to CC‐chemokine ligand 2 (CCL2) / monocyte chemoattractant protein (MCP‐1) in patients with advanced solid tumors

Advanced Solid Tumors ◽

Chemokine Ligand ◽

Cc Chemokine Ligand 2 ◽

Pre-final analysis of first-in-human, first-in-class, phase I clinical trial of CNTO 888, a human monoclonal antibody to the CC-chemokine ligand 2 (CCL2) in patients (pts) with advanced solid tumors.

Journal of Clinical Oncology ◽

10.1200/jco.2010.28.15_suppl.2548 ◽

2010 ◽

Vol 28 (15_suppl) ◽

pp. 2548-2548 ◽

Cited By ~ 1

Author(s):

M. D. Forster ◽

A. Patnaik ◽

S. K. Sandhu ◽

K. Papadopoulos ◽

B. J. Tromp ◽

...

Keyword(s):

Clinical Trial ◽

Monoclonal Antibody ◽

Phase I ◽

Solid Tumors ◽

Final Analysis ◽

Advanced Solid Tumors ◽

Chemokine Ligand ◽

Cc Chemokine Ligand 2 ◽

A first-in-human, first-in-class, phase I study of carlumab (CNTO 888), a human monoclonal antibody against CC-chemokine ligand 2 in patients with solid tumors

Cancer Chemotherapy and Pharmacology ◽

10.1007/s00280-013-2099-8 ◽

2013 ◽

Vol 71 (4) ◽

pp. 1041-1050 ◽

Cited By ~ 120

Author(s):

Shahneen K. Sandhu ◽

Kyri Papadopoulos ◽

Peter C. Fong ◽

Amita Patnaik ◽

Christina Messiou ◽

...

Keyword(s):

Monoclonal Antibody ◽

Phase I ◽

Solid Tumors ◽

Phase I Study ◽

Cc Chemokine ◽

Chemokine Ligand ◽

Cc Chemokine Ligand 2 ◽

Phase 2 study of carlumab (CNTO 888), a human monoclonal antibody against CC-chemokine ligand 2 (CCL2), in metastatic castration-resistant prostate cancer

Investigational New Drugs ◽

10.1007/s10637-012-9869-8 ◽

2012 ◽

Vol 31 (3) ◽

pp. 760-768 ◽

Cited By ~ 143

Author(s):

Kenneth J. Pienta ◽

Jean-Pascal Machiels ◽

Dirk Schrijvers ◽

Boris Alekseev ◽

Mikhail Shkolnik ◽

...

Keyword(s):

Prostate Cancer ◽

Monoclonal Antibody ◽

Phase 2 ◽

Castration Resistant Prostate Cancer ◽

Castration Resistant ◽

Phase 2 Study ◽

Chemokine Ligand ◽

Cc Chemokine Ligand 2 ◽

Monocyte chemoattractant protein-1/CC chemokine ligand 2 enhances apoptotic cell removal by macrophages through Rac1 activation

Biochemical and Biophysical Research Communications ◽

10.1016/j.bbrc.2010.07.141 ◽

2010 ◽

Vol 399 (4) ◽

pp. 677-682 ◽

Cited By ~ 29

Author(s):

Takeshi Tanaka ◽

Mayumi Terada ◽

Koya Ariyoshi ◽

Konosuke Morimoto

Keyword(s):

Apoptotic Cell ◽

Cc Chemokine ◽

Chemokine Ligand ◽

Cc Chemokine Ligand 2 ◽

Critical Role of Monocyte Chemoattractant Protein-1/CC Chemokine Ligand 2 in the Pathogenesis of Ischemic Cardiomyopathy

Circulation ◽

10.1161/circulationaha.106.646091 ◽

2007 ◽

Vol 115 (5) ◽

pp. 584-592 ◽

Cited By ~ 166

Author(s):

Nikolaos G. Frangogiannis ◽

Oliver Dewald ◽

Ying Xia ◽

Guofeng Ren ◽

Sandra Haudek ◽

...

Keyword(s):

Ischemic Cardiomyopathy ◽

Critical Role ◽

Cc Chemokine ◽

Chemokine Ligand ◽

Cc Chemokine Ligand 2 ◽

The Effect of Monocyte Chemoattractant Protein-1/CC Chemokine Ligand 2 on Aqueous Humor Outflow Facility

Investigative Opthalmology & Visual Science ◽

10.1167/iovs.12-10376 ◽

2012 ◽

Vol 53 (10) ◽

pp. 6702 ◽

Cited By ~ 6

Author(s):

Naoko Tsuboi ◽

Toshihiro Inoue ◽

Motofumi Kawai ◽

Miyuki Inoue-Mochita ◽

Tomokazu Fujimoto ◽

...

Keyword(s):

Aqueous Humor ◽

Outflow Facility ◽

Cc Chemokine ◽

Aqueous Humor Outflow ◽

Chemokine Ligand ◽

Cc Chemokine Ligand 2 ◽

IL-17–Mediated Monocyte Migration Occurs Partially through CC Chemokine Ligand 2/Monocyte Chemoattractant Protein-1 Induction

The Journal of Immunology ◽

10.4049/jimmunol.0901942 ◽

2010 ◽

Vol 184 (8) ◽

pp. 4479-4487 ◽

Cited By ~ 96

Author(s):

Shiva Shahrara ◽

Sarah R. Pickens ◽

Arthur M. Mandelin ◽

William J. Karpus ◽

Qiquan Huang ◽

...

Keyword(s):

Cc Chemokine ◽

Monocyte Migration ◽

Chemokine Ligand ◽

Cc Chemokine Ligand 2 ◽

Saliva fromLutzomyia longipalpisInduces CC Chemokine Ligand 2/Monocyte Chemoattractant Protein-1 Expression and Macrophage Recruitment

The Journal of Immunology ◽

10.4049/jimmunol.175.12.8346 ◽

2005 ◽

Vol 175 (12) ◽

pp. 8346-8353 ◽

Cited By ~ 52

Author(s):

Clarissa R. Teixeira ◽

Maria Jânia Teixeira ◽

Regis B. B. Gomes ◽

Claire S. Santos ◽

Bruno B. Andrade ◽

...

Keyword(s):

Cc Chemokine ◽

Macrophage Recruitment ◽

Chemokine Ligand ◽

Cc Chemokine Ligand 2 ◽

MCP-1/CCL2 (Monocyte Chemoattractant Protein-1/CC Chemokine Ligand-2) Enhance Apoptotic Cells Removal (Efferocytosis) through Activation of Rac1.

10.1164/ajrccm-conference.2009.179.1_meetingabstracts.a3724 ◽

2009 ◽

Author(s):

T Tanaka ◽

M Terada ◽

K Morimoto ◽

K Ariyoshi

Keyword(s):

Apoptotic Cells ◽

Cc Chemokine ◽

Chemokine Ligand ◽

Cc Chemokine Ligand 2 ◽

Monocyte Chemoattractant Protein-1/CC Chemokine Ligand 2 Controls Microtubule-Driven Biogenesis and Leukotriene B4-Synthesizing Function of Macrophage Lipid Bodies Elicited by Innate Immune Response

The Journal of Immunology ◽

10.4049/jimmunol.179.12.8500 ◽

2007 ◽

Vol 179 (12) ◽

pp. 8500-8508 ◽

Cited By ~ 61

Author(s):

Patricia Pacheco ◽

Adriana Vieira-de-Abreu ◽

Rachel N. Gomes ◽

Giselle Barbosa-Lima ◽

Leticia B. Wermelinger ◽

...

Keyword(s):

Immune Response ◽

Leukotriene B4 ◽

Innate Immune ◽

Lipid Bodies ◽

Chemokine Ligand ◽

Cc Chemokine Ligand 2 ◽