Abstract B007: OKI-179 is a novel, oral, class I specific histone deacetylase inhibitor in phase 1 clinical trials

2019 ◽  
Author(s):  
Jennifer R Diamond ◽  
Jodi A Kagihara ◽  
Xuedong Liu ◽  
Gilad Gordon ◽  
Amy M Heim ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Histone Deacetylase ◽  
Histone Deacetylase Inhibitor ◽  
Phase 1 ◽  
Class I ◽  
Deacetylase Inhibitor

scholarly journals Class I histone deacetylase inhibitor MS-275 attenuates vasoconstriction and inflammation in angiotensin II-induced hypertension

PLoS ONE ◽  
2019 ◽  
Vol 14 (3) ◽  
pp. e0213186 ◽  
Author(s):  
Yuhee Ryu ◽  
Hae Jin Kee ◽  
Simei Sun ◽  
Young Mi Seok ◽  
Sin Young Choi ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Histone Deacetylase ◽  
Histone Deacetylase Inhibitor ◽  
Class I ◽  
Deacetylase Inhibitor ◽  
Induced Hypertension

scholarly journals Total Synthesis and Biological Mode of Action of Largazole: A Potent Class I Histone Deacetylase Inhibitor

2008 ◽  
Vol 130 (33) ◽  
pp. 11219-11222 ◽  
Author(s):  
Albert Bowers ◽  
Nathan West ◽  
Jack Taunton ◽  
Stuart L. Schreiber ◽  
James E. Bradner ◽  
...  
Keyword(s):  
Total Synthesis ◽  
Histone Deacetylase ◽  
Mode Of Action ◽  
Histone Deacetylase Inhibitor ◽  
Class I ◽  
Deacetylase Inhibitor

Discovery of a Potent Class I Selective Ketone Histone Deacetylase Inhibitor with Antitumor Activity in Vivo and Optimized Pharmacokinetic Properties

2009 ◽  
Vol 52 (11) ◽  
pp. 3453-3456 ◽  
Author(s):  
Olaf Kinzel ◽  
Laura Llauger-Bufi ◽  
Giovanna Pescatore ◽  
Michael Rowley ◽  
Carsten Schultz-Fademrecht ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
Histone Deacetylase ◽  
Histone Deacetylase Inhibitor ◽  
Class I ◽  
Deacetylase Inhibitor ◽  
Pharmacokinetic Properties

scholarly journals Phase 1 study of oral abexinostat, a histone deacetylase inhibitor, in combination with doxorubicin in patients with metastatic sarcoma

Cancer ◽  
2014 ◽  
Vol 121 (8) ◽  
pp. 1223-1230 ◽  
Author(s):  
Edwin Choy ◽  
Yael Flamand ◽  
Sriram Balasubramanian ◽  
James E. Butrynski ◽  
David C. Harmon ◽  
...  
Keyword(s):  
Histone Deacetylase ◽  
Histone Deacetylase Inhibitor ◽  
Phase 1 ◽  
Phase 1 Study ◽  
Deacetylase Inhibitor ◽  
Metastatic Sarcoma

Preclinical development of the class I selective histone deacetylase inhibitor OKI-179 for the treatment of solid tumors

2021 ◽  
pp. molcanther.0455.2021
Author(s):  
Jennifer R. Diamond ◽  
Todd M. Pitts ◽  
Dana Ungermannova ◽  
Christopher G Nasveschuk ◽  
Gan Zhang ◽  
...  
Keyword(s):  
Solid Tumors ◽  
Histone Deacetylase ◽  
Histone Deacetylase Inhibitor ◽  
Class I ◽  
Preclinical Development ◽  
Deacetylase Inhibitor
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