Abstract 732: Targeting the Bcl-2/BH3 protein-protein interaction: Identification, design, and synthesis of new selective inhibitors of the Mcl-1/BH3 interaction

2010 ◽  
Author(s):  
Daniele Pernazza ◽  
Harshani R. Lawrence ◽  
Kenichiro Doi ◽  
Shen-Shu Sung ◽  
Wayne C. Guida ◽  
...  
Keyword(s):  
Protein Interaction ◽  
Selective Inhibitors ◽  
Protein Protein Interaction ◽  
Design And Synthesis

Design and synthesis of protein–protein interaction mimics as Plasmodium falciparum cysteine protease, falcipain-2 inhibitors

2011 ◽  
Vol 46 (6) ◽  
pp. 2083-2090 ◽  
Author(s):  
Luca Rizzi ◽  
Srividhya Sundararaman ◽  
Katarina Cendic ◽  
Nadia Vaiana ◽  
Reshma Korde ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
Protein Interaction ◽  
Cysteine Protease ◽  
Protein Protein Interaction ◽  
Design And Synthesis

scholarly journals Structure-Based Design and Synthesis of Potent Cyclic Peptides Inhibiting the YAP–TEAD Protein–Protein Interaction

2014 ◽  
Vol 5 (9) ◽  
pp. 993-998 ◽  
Author(s):  
Zhisen Zhang ◽  
Zhaohu Lin ◽  
Zheng Zhou ◽  
Hong C. Shen ◽  
S. Frank Yan ◽  
...  
Keyword(s):  
Protein Interaction ◽  
Cyclic Peptides ◽  
Protein Protein Interaction ◽  
Design And Synthesis

An efficient transient assays system using Agrobacterium-mediated transformation of onion (Allium cepa) epidermal cells

2020 ◽  
Vol 80 (03) ◽  
Author(s):  
Yu-Miao Zhang ◽  
Jun Wang ◽  
Tao Wu
Keyword(s):  
Subcellular Localization ◽  
Protein Interaction ◽  
Protein Interactions ◽  
Epidermal Cells ◽  
Cyclin Dependent Kinase ◽  
Protein Subcellular Localization ◽  
Protein Protein Interactions ◽  
Efficient System ◽  
Protein Protein Interaction ◽  
Onion Epidermal Cells

In this study, the Agrobacterium infection medium, infection duration, detergent, and cell density were optimized. The sorghum-based infection medium (SbIM), 10-20 min infection time, addition of 0.01% Silwet L-77, and Agrobacterium optical density at 600 nm (OD600), improved the competence of onion epidermal cells to support Agrobacterium infection at >90% efficiency. Cyclin-dependent kinase D-2 (CDKD-2) and cytochrome c-type biogenesis protein (CYCH), protein-protein interactions were localized. The optimized procedure is a quick and efficient system for examining protein subcellular localization and protein-protein interaction.

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