Abstract LB-230: Multiple omics profiling reveals the evolutionary history of metastatic renal cell carcinoma.

Renal cell carcinoma (RCC) is infamous for its unpredictable behavior and metastatic potential. We report a case of a patient with a complex history of multifocal renal cell carcinoma and chronic lymphocytic leukemia (CLL), who subsequently developed a parotid mass. Total parotidectomy revealed this mass to be an additional site of metastasis which had developed 19 years after his initial diagnosis of RCC.

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A FavorAx study of axitinib in favorable risk patients with metastatic renal cell carcinoma.

Journal of Clinical Oncology ◽

10.1200/jco.2018.36.6_suppl.666 ◽

2018 ◽

Vol 36 (6_suppl) ◽

pp. 666-666

Author(s):

Ilya Tsimafeyeu ◽

Pavel Borisov ◽

Ahmed Abdelgafur ◽

Roman Leonenkov ◽

Olga Novikova ◽

...

Keyword(s):

Renal Cell Carcinoma ◽

Adverse Events ◽

Cell Carcinoma ◽

Metastatic Renal Cell Carcinoma ◽

Primary Endpoint ◽

Renal Cell ◽

Response Rate ◽

Objective Response ◽

First Line ◽

History Of

666 Background: Targeted therapy with axitinib resulted in a greater objective response rate and prolonged progression-free survival (PFS) compared to sorafenib in patients with previously treated metastatic renal cell carcinoma (mRCC) in AXIS study. 75% of patients had intermediate and poor IMDC prognosis. In this phase 2 study, we assessed the activity of axitinib in mRCC patients with favourable risk and a history of prior VEGFR-directed therapy. Methods: Patients were required to have clear cell mRCC, favourable risk according to IMDC criteria, and to have received first-line treatment with sunitinib or pazopanib. Prior treatment with other agents was not permitted. The primary endpoint of the study was PFS. Additional endpoints included response rate, safety, and overall survival (OS). Results: A total of 21 patients were enrolled, 62% of whom were male. Median age was 59 years. 11 (52%) patients had 2 and more metastatic sites. 67% and 33% of patients received first-line sunitinib or pazopanib with a median PFS of 17 months (95% CI 14-20). After a median follow-up of 16 months, the median PFS and OS was not yet reached. The current study did achieve its primary endpoint based on the 10-month PFS of 71.4%. 3 (14.3%) patients had confirmed partial responses and 14 (66.7%) had stable disease. No grade 3/4 treatment-related adverse events were observed; the most frequent grade 1/2 treatment-related adverse events were hypertension (57.1%), fatigue (57.1%), GI (33%) and skin (19%) toxicity. 7 patients had dose-escalation of axitinib and 1 patient had dose reduction. Conclusions: The encouraging PFS and favorable safety profile observed in FavorAx study support the administration of axitinib in mRCC patients with favourable IMDC risk and a history of prior sunitinib or pazopanib. Clinical trial information: NCT02700568.

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The Natural History of Metastatic Renal Cell Carcinoma: A Computer Analysis

The Journal of Urology ◽

10.1016/s0022-5347(17)57082-2 ◽

1978 ◽

Vol 120 (2) ◽

pp. 148-152 ◽

Cited By ~ 378

Author(s):

Jean B. Dekernion ◽

Kenneth P. Ramming ◽

Robert B. Smith

Keyword(s):

Renal Cell Carcinoma ◽

Natural History ◽

Cell Carcinoma ◽

Metastatic Renal Cell Carcinoma ◽

Computer Analysis ◽

Renal Cell ◽

History Of

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Metastatic renal cell carcinoma in the head and neck region

International Journal of Otorhinolaryngology and Head and Neck Surgery ◽

10.18203/issn.2454-5929.ijohns20182721 ◽

2018 ◽

Vol 4 (4) ◽

pp. 1092

Author(s):

Sowjanya Gandla ◽

Veena Ramaswamy ◽

Vishal Rao

Keyword(s):

Renal Cell Carcinoma ◽

Cell Carcinoma ◽

Metastatic Renal Cell Carcinoma ◽

Renal Cell ◽

Left Kidney ◽

Neck Region ◽

Temporal Region ◽

Head And Neck Region ◽

History Of ◽

Left Temporal Region

<p>We describe 3 rare cases of metastatic renal cell carcinoma in the head and neck region. Our first case was a 72 years old male presented with profuse bleeding from the left ear. On examination, proliferative, pink, friable mass was present in the left external auditory canal. On eliciting the detailed history, it was found that patient had renal cell carcinoma in the left kidney four years back and underwent left radical nephrectomy. Patient underwent left lateral temporal bone resection with cul-de-sac closure. Histopathological examination of the specimen showed metastatic renal cell carcinoma. Our second case was a 64 years old male presented with complaints of growth in the oral cavity of 1 month duration. On examination, 5×3 cms proliferative growth was present in the hard palate. Biopsy from the growth in the hard palate showed metastatic renal cell carcinoma. Patient gave history of renal cell carcinoma in the past for which he did not receive treatment. Our third case was a 45 years old male who presented to us with a diffuse swelling in the left temporal region of 2 months duration. On examination, 3×2 cms swelling was present in the left temporal region. Patient had history of renal cell carcinoma of left kidney and underwent left nephrectomy one year prior to the presentation of the left temporal swelling. Ultrasonography guided biopsy of the left temporal region showed metastatic renal cell carcinoma.</p>

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Comorbidity and other predictors of survival in veterans with metastatic renal cell carcinoma (RCC).

Journal of Clinical Oncology ◽

10.1200/jco.2013.31.15_suppl.e15561 ◽

2013 ◽

Vol 31 (15_suppl) ◽

pp. e15561-e15561

Author(s):

Michael Cho ◽

Trent P Wang ◽

Melanie L. Gonzalez ◽

Victor T Chang ◽

Fengming Zhong ◽

...

Keyword(s):

Signal Transduction ◽

Renal Cell Carcinoma ◽

Cell Carcinoma ◽

Metastatic Renal Cell Carcinoma ◽

Renal Cell ◽

Clear Cell ◽

Co Morbidity ◽

Signal Transduction Inhibitors ◽

History Of ◽

Ecog Ps

e15561 Background: Comorbidity as a prognostic marker has been reported in several solid tumors. We examined whether co-morbidity indices predict survival in Veterans with metastatic renal cell carcinoma (RCC) who were treated with signal transduction inhibitors. Methods: In an IRB-approved protocol, we reviewed the records of patients (Pts) diagnosed with RCC at a VA Medical Center from 1/1/2000 to 12/31/2011. Age, ECOG Performance Status (ECOG PS), Hemoglobin (Hgb), Albumin (Alb), Corrected Calcium (CCa), history of Nephrectomy, and histology (clear cell (CC) vs. non clear cell (NCC)) were abstracted. Co-morbidity was assessed with Charlson Comorbidity Index (CCI), and the Kaplan-Feinstein Index (KFI). We developed a survival model with age, ECOG PS, Hgb, Alb, CCa, history of nephrectomy, and histology. Co-morbidity indices were tested by determining if they were independent predictors of survival after inclusion in this model. Cox regression analyses were performed with SAS V9.2. Results: There were 24 Pts;6 (25%) are alive. The Median (M) age when seen at VA was 64 years (54-85). The M Hgb level was 12.1g/dL (6.7-16.5), Alb was 4.1g/dL (2.8-5.0), and CCa was 9.19mg/dL (7.9-12.5). The M CCI was 4.2 (1.4-12.0) and KFI was 2.0 (1-3). The M Survival was 823 days (24-3482). 17(68%) pts had clear cell carcinoma and 18(72%) had nephrectomies Median ECOG PS was one range(0-4). The median number of treatments was 2, range 1-7. Results of univariate analyses with co-morbidity indices were significant for age (p < ,029) and history of nephrectomy p< .068). There were no multivariate predictors of survival. Conclusions: In the univariate analysis, ECOG PS as well as Nephrectomy status were significant predictors for M survival. CCI and KFI did not predict M survival. In distinction to other solid tumor histologies where chemotherapy is used, KFI and CCI in RCC may not be associated with overall survival due to either RCC histology or use of signal transduction inhibitors as treatment. Confirmatory studies should be done in larger populations. This was supported by the New Jersey Commission for Cancer Research.

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Metastatic renal cell carcinoma presenting as a breast mass in a woman with history of primary breast cancer

Journal of the Belgian Society of Radiology ◽

10.5334/jbr-btr.699 ◽

2011 ◽

Vol 94 (6) ◽

pp. 330

Author(s):

C Balliauw ◽

B Termote ◽

A Van Steen ◽

P Moerman ◽

M R Christiaens ◽

...

Keyword(s):

Breast Cancer ◽

Renal Cell Carcinoma ◽

Cell Carcinoma ◽

Metastatic Renal Cell Carcinoma ◽

Renal Cell ◽

Primary Breast Cancer ◽

Breast Mass ◽

History Of

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A Painful Finger: An Unusual Presentation of Von Hippel-Lindau-Associated Advanced Renal Cell Carcinoma

Case Reports in Oncology ◽

10.1159/000506444 ◽

2020 ◽

Vol 13 (1) ◽

pp. 245-248

Author(s):

Pui San Sarah Ho ◽

Li Yin Yip ◽

Mike Nguyen ◽

Weeragoda Wijesinghe ◽

Arvind Sahu

Keyword(s):

Renal Cell Carcinoma ◽

Cell Carcinoma ◽

Metastatic Renal Cell Carcinoma ◽

Renal Cell ◽

Clinical Suspicion ◽

Unusual Presentation ◽

Von Hippel Lindau ◽

Metastatic Lesions ◽

History Of ◽

Rare Situation

Bone is reported to be one of the most common sites of metastasis. Acrometastasis is an extremely rare situation and accounts for approximately 0.1% of all metastatic lesions to the skeleton. Here, we present a case of acrometastasis in a 55-year-old woman who presented with a 3-month history of atraumatic right ring fingertip pain and swelling and was subsequently diagnosed with metastatic renal cell carcinoma. This report highlights the importance of clinical suspicion of malignancy at unusual sites in the setting of non-resolving symptoms.

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