Abstract 2463: Suppression of hepatocyte nuclear factor 4α by nuclear factor κB in hepatoma cells

2014 ◽  
Author(s):  
Bei-Fang Ning ◽  
Xin Zhang ◽  
Wei-Fen Xie
Keyword(s):  
Nuclear Factor Κb ◽  
Hepatoma Cells ◽  
Nuclear Factor ◽  
Hepatocyte Nuclear Factor ◽  
Hepatocyte Nuclear Factor 4Α

scholarly journals Hepatocyte nuclear factor 4α and cancer-related cell signaling pathways: a promising insight into cancer treatment

2021 ◽  
Vol 53 (1) ◽  
pp. 8-18
Author(s):  
Duo-Duo Lv ◽  
Ling-Yun Zhou ◽  
Hong Tang
Keyword(s):  
Signaling Pathways ◽  
Transforming Growth Factor ◽  
Critical Factor ◽  
Transforming Growth Factor Β ◽  
Nuclear Factor Κb ◽  
Nuclear Factor ◽  
Hepatocyte Nuclear Factor ◽  
Cellular Processes ◽  
Hepatocyte Nuclear Factor 4Α ◽  
Transcription 3

AbstractHepatocyte nuclear factor 4α (HNF4α), a member of the nuclear receptor superfamily, is described as a protein that binds to the promoters of specific genes. It controls the expression of functional genes and is also involved in the regulation of numerous cellular processes. A large number of studies have demonstrated that HNF4α is involved in many human malignancies. Abnormal expression of HNF4α is emerging as a critical factor in cancer cell proliferation, apoptosis, invasion, dedifferentiation, and metastasis. In this review, we present emerging insights into the roles of HNF4α in the occurrence, progression, and treatment of cancer; reveal various mechanisms of HNF4α in cancer (e.g., the Wnt/β-catenin, nuclear factor-κB, signal transducer and activator of transcription 3, and transforming growth factor β signaling pathways); and highlight potential clinical uses of HNF4α as a biomarker and therapeutic target for cancer.

Hepatocyte nuclear factor 4α-nuclear factor-κB feedback circuit modulates liver cancer progression

Hepatology ◽  
2014 ◽  
Vol 60 (5) ◽  
pp. 1607-1619 ◽  
Author(s):  
Bei-Fang Ning ◽  
Jin Ding ◽  
Jiao Liu ◽  
Chuan Yin ◽  
Wen-Ping Xu ◽  
...  
Keyword(s):  
Liver Cancer ◽  
Cancer Progression ◽  
Nuclear Factor Κb ◽  
Nuclear Factor ◽  
Feedback Circuit ◽  
Hepatocyte Nuclear Factor ◽  
Hepatocyte Nuclear Factor 4Α
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