Abstract 3270: Gene expression profiling of breast tumors from African American and Caucasian women: Are molecular differences meaningful

2014 ◽  
Author(s):  
Allyson L. Valente ◽  
Craig D. Shriver ◽  
Rachel E. Ellsworth
Keyword(s):  
Gene Expression ◽  
African American ◽  
Gene Expression Profiling ◽  
Expression Profiling ◽  
Breast Tumors ◽  
Caucasian Women

scholarly journals Gene expression profiling of triple-negative breast tumors with different expression of secreted protein acidic and cysteine rich (SPARC)

2018 ◽  
Vol 7 (2) ◽  
pp. BMT09
Author(s):  
Paulo R de Alcantara Filho ◽  
Flavia R Mangone ◽  
Ana C Pavanelli ◽  
Simone A de Bessa Garcia ◽  
Suely Nonogaki ◽  
...  
Keyword(s):  
Gene Expression ◽  
Gene Expression Profiling ◽  
Expression Profiling ◽  
Triple Negative ◽  
Breast Tumors ◽  
Secreted Protein

Abstract 555: Gene expression differences in primary breast tumors from African American and Caucasian women.

2008 ◽  
Author(s):  
Lori A Field ◽  
Brad Love ◽  
Brenda Deyarmin ◽  
Jennifer Kane ◽  
Jeffrey A Hooke ◽  
...  
Keyword(s):  
Gene Expression ◽  
African American ◽  
Breast Tumors ◽  
Caucasian Women

scholarly journals PCR analysis of the effect of photodynamic therapy on breast tumors

2021 ◽  
Vol 10 (12) ◽  
pp. e459101220468
Author(s):  
Isabelle Ferreira ◽  
Glenda Nicioli da Silva ◽  
Juliana Ferreira-Strixino ◽  
Clovis Grecco ◽  
Vanderlei Salvador Bagnato ◽  
...  
Keyword(s):  
Gene Expression ◽  
Cell Death ◽  
Photodynamic Therapy ◽  
Gene Expression Profiling ◽  
Expression Profiling ◽  
Breast Tumor ◽  
Breast Tumors ◽  
Female Rats ◽  
Control Group ◽  
Her 2

Photodynamic therapy (PDT) is a promising therapeutic modality for treating cancer, including breast tumors. The oxidative damage caused by PDT culminates in cell death, induction of immune response, and the resulting destruction of the tumor. This study aimed to evaluate the gene expression profiling of genes BCL-2, BAX, and HER-2 and their proteins after PDT, associating it with the necrosis caused by this therapy under different fluences. Twenty-eight female rats received a single dose of 7,12-dimethylbenz (a) anthracene (DMBA - 80mg/kg), by gavage, for breast tumor induction. After the tumors grew, the animals were divided into four groups: G1 - control group – untreated breast tumor – and G2, G3, and G4 groups treated with PDT using Photogem@ as photosensitizer and interstitial irradiation, with fluences of 50J/cm, 100J/cm, and 150J/cm, respectively. Samples of tumors were harvested for histological examination by RT-qPCR. The RT-qPCR showed that the gene expression profiling of BCL-2, BAX, and HER-2 was not altered after PDT. Hemorrhagic necrosis and qualitatively greater vascular and cellular damage were observed and correlated positively with the fluence. PDT does not seem to induce the modulation of genes related to apoptosis. The results indicate that the type of cell death stimulated by PDT in breast tumor is necrosis.

Sign in / Sign up

Export Citation Format

Share Document