Abstract 5299: Machine learning approach to personalized medicine in breast cancer patients: Development of data-driven, personalized, causal modeling through identification and understanding of optimal treatments for predicting better disease outcomes

Author(s):  
Henry Kaplan ◽  
Anna Berry ◽  
Kristine Rinn ◽  
Erin Ellis ◽  
George Birchfield ◽  
...  
2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Pratyusha Rakshit ◽  
Onintze Zaballa ◽  
Aritz Pérez ◽  
Elisa Gómez-Inhiesto ◽  
Maria T. Acaiturri-Ayesta ◽  
...  

AbstractThis paper presents a novel machine learning approach to perform an early prediction of the healthcare cost of breast cancer patients. The learning phase of our prediction method considers the following two steps: (1) in the first step, the patients are clustered taking into account the sequences of actions undergoing similar clinical activities and ensuring similar healthcare costs, and (2) a Markov chain is then learned for each group to describe the action-sequences of the patients in the cluster. A two step procedure is undertaken in the prediction phase: (1) first, the healthcare cost of a new patient’s treatment is estimated based on the average healthcare cost of its k-nearest neighbors in each group, and (2) finally, an aggregate measure of the healthcare cost estimated by each group is used as the final predicted cost. Experiments undertaken reveal a mean absolute percentage error as small as 6%, even when half of the clinical records of a patient is available, substantiating the early prediction capability of the proposed method. Comparative analysis substantiates the superiority of the proposed algorithm over the state-of-the-art techniques.


2021 ◽  
Vol 161 ◽  
pp. S921-S922
Author(s):  
E. Rodríguez-Tomàs ◽  
G. Baiges-Gaya ◽  
J. Acosta ◽  
L. Torres ◽  
H. Castañé ◽  
...  

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