scholarly journals Abstract 2001: Inhibiting voltage-gated sodium channel activity in medullary thyroid cancer using small molecule compounds

2019 ◽  
Author(s):  
Paras Ahuja ◽  
Rachael Guenter ◽  
Jaden Cowan ◽  
Yazen Shihab ◽  
Jason Whitt ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Sodium Channel ◽  
Small Molecule ◽  
Medullary Thyroid Cancer ◽  
Channel Activity ◽  
Voltage Gated Sodium Channel ◽  
Medullary Thyroid ◽  
Voltage Gated

scholarly journals Voltage-gated Sodium Channel Activity Promotes Cysteine Cathepsin-dependent Invasiveness and Colony Growth of Human Cancer Cells

2009 ◽  
Vol 284 (13) ◽  
pp. 8680-8691 ◽  
Author(s):  
Ludovic Gillet ◽  
Sébastien Roger ◽  
Pierre Besson ◽  
Fabien Lecaille ◽  
Jacques Gore ◽  
...  
Keyword(s):  
Sodium Channel ◽  
Cancer Cells ◽  
Human Cancer ◽  
Colony Growth ◽  
Channel Activity ◽  
Voltage Gated Sodium Channel ◽  
Voltage Gated ◽  
Human Cancer Cells ◽  
Cysteine Cathepsin

scholarly journals Nedd4-2 (NEDD4L) controls intracellular Na+-mediated activity of voltage-gated sodium channels in primary cortical neurons

2013 ◽  
Vol 457 (1) ◽  
pp. 27-31 ◽  
Author(s):  
Jenny A. Ekberg ◽  
Natasha A. Boase ◽  
Grigori Rychkov ◽  
Jantina Manning ◽  
Philip Poronnik ◽  
...  
Keyword(s):  
Sodium Channel ◽  
Sodium Channels ◽  
Ubiquitin Ligase ◽  
Cortical Neurons ◽  
Channel Activity ◽  
Primary Cortical Neurons ◽  
Voltage Gated Sodium Channel ◽  
Voltage Gated ◽  
Voltage Gated Sodium Channels ◽  
First Time

The study shows for the first time that the ubiquitin ligase Nedd4-2 regulates voltage-gated sodium channel activity in cortical neurons, specifically in response to elevated intracellular Na+ concentration.

Voltage-gated sodium channel activity promotes prostate cancer metastasis in vivo

2012 ◽  
Vol 323 (1) ◽  
pp. 58-61 ◽  
Author(s):  
Senay Yildirim ◽  
Seyhan Altun ◽  
Hatice Gumushan ◽  
Anup Patel ◽  
Mustafa B.A. Djamgoz
Keyword(s):  
Prostate Cancer ◽  
Sodium Channel ◽  
Cancer Metastasis ◽  
Channel Activity ◽  
Voltage Gated Sodium Channel ◽  
Voltage Gated ◽  
Prostate Cancer Metastasis

scholarly journals Pharmacologic Characterization of AMG8379, a Potent and Selective Small Molecule Sulfonamide Antagonist of the Voltage-Gated Sodium Channel NaV1.7

2017 ◽  
Vol 362 (1) ◽  
pp. 146-160 ◽  
Author(s):  
Thomas J. Kornecook ◽  
Ruoyuan Yin ◽  
Stephen Altmann ◽  
Xuhai Be ◽  
Virginia Berry ◽  
...  
Keyword(s):  
Sodium Channel ◽  
Small Molecule ◽  
Voltage Gated Sodium Channel ◽  
Voltage Gated

Abstract #1101 The Value of Calcitonin Calcium Stimulation Test Levels as Predictors of Medullary Thyroid Cancer.

2018 ◽  
Vol 24 ◽  
pp. 273-274
Author(s):  
Corin Badiu ◽  
Mara Baet ◽  
Ruxandra Dobrescu ◽  
Andra Caragheorgheopol ◽  
Corneci Cristina
Keyword(s):  
Thyroid Cancer ◽  
Medullary Thyroid Cancer ◽  
Stimulation Test ◽  
Medullary Thyroid ◽  
Calcium Stimulation
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