Abstract LB-179: Pre- and post-diagnosis body mass index, weight change, and prostate cancer-specific mortality among prostate cancer survivors in the US

2019 ◽  
Author(s):  
Alyssa N. Troeschel ◽  
Eric J. Jacobs ◽  
W. Dana Flanders ◽  
Victoria L. Stevens ◽  
Terryl J. Hartman ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Body Mass Index ◽  
Cancer Survivors ◽  
Body Mass ◽  
Weight Change ◽  
Prostate Cancer Survivors ◽  
The Us ◽  
Specific Mortality ◽  
Cancer Specific Mortality ◽  
Index Weight

scholarly journals Body Mass Index, Weight Change, and Risk of Prostate Cancer in the Cancer Prevention Study II Nutrition Cohort

2006 ◽  
Vol 16 (1) ◽  
pp. 63-69 ◽  
Author(s):  
Carmen Rodriguez ◽  
Stephen J. Freedland ◽  
Anusila Deka ◽  
Eric J. Jacobs ◽  
Marjorie L. McCullough ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Body Mass Index ◽  
Cancer Prevention ◽  
Body Mass ◽  
Weight Change ◽  
Prevention Study ◽  
Index Weight

scholarly journals Fatty Acid Synthase Polymorphisms, Tumor Expression, Body Mass Index, Prostate Cancer Risk, and Survival

2010 ◽  
Vol 28 (25) ◽  
pp. 3958-3964 ◽  
Author(s):  
Paul L. Nguyen ◽  
Jing Ma ◽  
Jorge E. Chavarro ◽  
Matthew L. Freedman ◽  
Rosina Lis ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Body Mass Index ◽  
Fatty Acid ◽  
Body Mass ◽  
Fatty Acid Synthase ◽  
Prostate Cancer Risk ◽  
De Novo Lipogenesis ◽  
Variant Allele ◽  
Specific Mortality ◽  
Tumor Expression

Purpose Fatty acid synthase (FASN) regulates de novo lipogenesis, body weight, and tumor growth. We examined whether common germline single nucleotide polymorphisms (SNPs) in the FASN gene affect prostate cancer (PCa) risk or PCa-specific mortality and whether these effects vary by body mass index (BMI). Methods In a prospective nested case-control study of 1,331 white patients with PCa and 1,267 age-matched controls, we examined associations of five common SNPs within FASN (and 5 kb upstream/downstream, R2 > 0.8) with PCa incidence and, among patients, PCa-specific death and tested for an interaction with BMI. Survival analyses were repeated for tumor FASN expression (n = 909). Results Four of the five SNPs were associated with lethal PCa. SNP rs1127678 was significantly related to higher BMI and interacted with BMI for both PCa risk (Pinteraction = .004) and PCa mortality (Pinteraction = .056). Among overweight men (BMI ≥ 25 kg/m2), but not leaner men, the homozygous variant allele carried a relative risk of advanced PCa of 2.49 (95% CI, 1.00 to 6.23) compared with lean men with the wild type. Overweight patients carrying the variant allele had a 2.04 (95% CI, 1.31 to 3.17) times higher risk of PCa mortality. Similarly, overweight patients with elevated tumor FASN expression had a 2.73 (95% CI, 1.05 to 7.08) times higher risk of lethal PCa (Pinteraction = .02). Conclusion FASN germline polymorphisms were significantly associated with risk of lethal PCa. Significant interactions of BMI with FASN polymorphisms and FASN tumor expression suggest FASN as a potential link between obesity and poor PCa outcome and raise the possibility that FASN inhibition could reduce PCa-specific mortality, particularly in overweight men.

scholarly journals Body Mass Index, Weight Change, and Clinical Progression in Mild Cognitive Impairment and Alzheimer Disease

2014 ◽  
Vol 28 (1) ◽  
pp. 36-43 ◽  
Author(s):  
Lilah M. Besser ◽  
Dawn P. Gill ◽  
Sarah E. Monsell ◽  
Willa Brenowitz ◽  
Dana H. Meranus ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Alzheimer Disease ◽  
Body Mass ◽  
Weight Change ◽  
Clinical Progression ◽  
Index Weight

scholarly journals Body Mass Index and Weight Change in Men with Prostate Cancer: Progression and Mortality.

2015 ◽  
Vol 44 (suppl_1) ◽  
pp. i141-i142
Author(s):  
S. E. Bonn ◽  
F. Wiklund ◽  
A. Sjölander ◽  
R. Szulkin ◽  
P. Stattin ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Body Mass Index ◽  
Body Mass ◽  
Cancer Progression ◽  
Weight Change ◽  
Prostate Cancer Progression
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