Abstract PD2-01: Exploring CDK4/6 inhibitor therapy response and drug resistance development at the single cell level in metastatic breast cancer CTCs

2020 ◽  
Author(s):  
Andreas Trumpp ◽  
Lisa Becker ◽  
Michael Fletcher ◽  
Roberto Würth ◽  
Anand Thippeswamy ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Drug Resistance ◽  
Metastatic Breast Cancer ◽  
Single Cell ◽  
Metastatic Breast ◽  
Therapy Response ◽  
Inhibitor Therapy ◽  
Single Cell Level ◽  
Cell Level ◽  
Resistance Development

scholarly journals Heterogeneity of PIK3CA mutational status at the single cell level in circulating tumor cells from metastatic breast cancer patients

2014 ◽  
Vol 9 (4) ◽  
pp. 749-757 ◽  
Author(s):  
Marta Pestrin ◽  
Francesca Salvianti ◽  
Francesca Galardi ◽  
Francesca De Luca ◽  
Natalie Turner ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Metastatic Breast Cancer ◽  
Single Cell ◽  
Cancer Patients ◽  
Tumor Cells ◽  
Metastatic Breast ◽  
Single Cell Level ◽  
Breast Cancer Patients ◽  
Cell Level ◽  
Mutational Status

HTAPP_Acquisition and allocation of fresh metastatic breast cancer samples v1

2021 ◽  
Author(s):  
Karla Helvie ◽  
Laura DelloStritto ◽  
Lori Marini ◽  
Nelly Oliver ◽  
Miraj Patel ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Metastatic Breast Cancer ◽  
Single Cell ◽  
Rna Sequencing ◽  
Cancer Genomics ◽  
Metastatic Breast ◽  
Standard Operating Procedure ◽  
Quality Data ◽  
Sample Collection ◽  
Spatial Profiling

This standard operating procedure was established by the Center for Cancer Genomics at Dana-Farber Cancer Institute, the Brigham and Women's Hospital and the Klarman Cell Observatory at the Broad Institute, to standardize the collection of fresh metastatic breast cancer biopsies and their allocation to various bulk and single cell assays, including whole exome and bulk RNA-sequencing, single-cell RNA sequencing, and spatial profiling of RNA and protein. The use of a well defined workflow has allowed us to generate high quality data from these different assays, by implementing efficient modes of communication, minimizing the time elapsed from sample collection to preservation or processing, and ensuring optimal transportation conditions. Visual Abstract

scholarly journals Molecular Biomarkers for Prediction of Targeted Therapy Response in Metastatic Breast Cancer: Trick or Treat?

2017 ◽  
Vol 18 (1) ◽  
pp. 85 ◽  
Author(s):  
Angela Toss ◽  
Marta Venturelli ◽  
Chiara Peterle ◽  
Federico Piacentini ◽  
Stefano Cascinu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Metastatic Breast Cancer ◽  
Targeted Therapy ◽  
Metastatic Breast ◽  
Therapy Response ◽  
Molecular Biomarkers

scholarly journals Single-Cell Mobility Analysis of Metastatic Breast Cancer Cells

2018 ◽  
Vol 5 (12) ◽  
pp. 1801158 ◽  
Author(s):  
Jialang Zhuang ◽  
Yongjian Wu ◽  
Liang Chen ◽  
Siping Liang ◽  
Minhao Wu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Metastatic Breast Cancer ◽  
Single Cell ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Metastatic Breast ◽  
Mobility Analysis ◽  
Cell Mobility

scholarly journals Single-cell analysis reveals a stem-cell program in human metastatic breast cancer cells

Nature ◽  
2015 ◽  
Vol 526 (7571) ◽  
pp. 131-135 ◽  
Author(s):  
Devon A. Lawson ◽  
Nirav R. Bhakta ◽  
Kai Kessenbrock ◽  
Karin D. Prummel ◽  
Ying Yu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Stem Cell ◽  
Metastatic Breast Cancer ◽  
Single Cell ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Single Cell Analysis ◽  
Metastatic Breast ◽  
Cell Analysis
Sign in / Sign up

Export Citation Format

Share Document