Abstract PS3-28: Three-dimensional H-scan ultrasound imaging for acute detection of breast cancer response to neoadjuvant treatment - Initial results using a preclinical animal model

2021 ◽  
Author(s):  
Haowei Tai ◽  
Shreya Reddy ◽  
Jane Song ◽  
Mawia Khairalseed ◽  
Kenneeth Hoyt
Keyword(s):  
Breast Cancer ◽  
Animal Model ◽  
Ultrasound Imaging ◽  
Neoadjuvant Treatment ◽  
Three Dimensional ◽  
Preclinical Animal Model ◽  
Initial Results

Three-dimensional ultrasound imaging of breast cancer by a real-time intraoperative navigation system

Breast Cancer ◽  
2005 ◽  
Vol 12 (2) ◽  
pp. 122-129 ◽  
Author(s):  
Tomoo Inoue ◽  
Yasuhiro Tamaki ◽  
Yoshinobu Sato ◽  
Masahiko Nakamoto ◽  
Shinichi Tamura ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Real Time ◽  
Ultrasound Imaging ◽  
Navigation System ◽  
Three Dimensional ◽  
Intraoperative Navigation

vHTS and 3D-QSAR for the Identification of Novel Phyto-inhibitors of Farnesyltransferase: Validation of Ascorbic Acid inhibition of Farnesyltransferase in an Animal Model of Breast Cancer

Drug Research ◽  
2021 ◽  
Author(s):  
Damilohun Samuel Metibemu
Keyword(s):  
Breast Cancer ◽  
Animal Model ◽  
Ascorbic Acid ◽  
Curcuma Longa ◽  
Three Dimensional ◽  
3D Qsar ◽  
Qsar Model ◽  
Quantitative Structure Activity Relationship ◽  
Farnesyltransferase Inhibitors ◽  
Hydrogen Bond Interactions

AbstractFarnesyltransferase (FTase) is a zinc enzyme that has been the subject of attention in anti-cancer research over the past. In this study, phytochemicals from Curcuma longa L., Taraxacum officinale, and Spondias mombin plants were screened for their inhibitory potentials on the human farnesyltransferase. A three-dimensional quantitative structure-activity relationship (3D-QSAR) model for the inhibition of farnesyltransferase was generated and the inhibition of farnesyltransferase by the hit, ascorbic acid was validated in an animal model of breast cancer. The lead compound, ascorbic acid makes extensive hydrogen bond interactions with key residues, lys-353, tyr-300, gly-290, leu-290 within the active site of farnesyltransferase. It downregulated the expression of FNTA mRNA in an animal model of breast cancer. The 3D-QSAR generated herein is robust, thoroughly validated, and should be employed in the pipelining of novel farnesyltransferase inhibitors. Ascorbic acid demonstrates its anticancer potentials through the inhibition of farnesyltransferase.

Three-Dimensional H-Scan Ultrasound Imaging of Early Breast Cancer Response to Neoadjuvant Therapy in a Murine Model

2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Haowei Tai ◽  
Jane Song ◽  
Junjie Li ◽  
Shreya Reddy ◽  
Mawia Khairalseed ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Neoadjuvant Therapy ◽  
Early Breast Cancer ◽  
Ultrasound Imaging ◽  
Murine Model ◽  
Three Dimensional
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