Abstract B27: Interaction of mammographic breast density with menopausal status and postmenopausal hormone use in relation to the risk of aggressive breast cancer subtypes

Author(s):  
Lusine Yaghjyan ◽  
Rulla Tamimi ◽  
Kimberly Bertrand ◽  
Christopher G. Scott ◽  
Matthew R. Jensen ◽  
...  
2019 ◽  
Vol 30 (10) ◽  
pp. 1103-1111 ◽  
Author(s):  
Lusine Yaghjyan ◽  
Ashwini K. Esnakula ◽  
Christopher G. Scott ◽  
Akemi T. Wijayabahu ◽  
Matthew R. Jensen ◽  
...  

2018 ◽  
Vol 29 (8) ◽  
pp. 751-758
Author(s):  
Lusine Yaghjyan ◽  
Graham Colditz ◽  
Heather Eliassen ◽  
Bernard Rosner ◽  
Aleksandra Gasparova ◽  
...  

2010 ◽  
Vol 8 (10) ◽  
pp. 1157-1165 ◽  
Author(s):  
Renee W. Pinsky ◽  
Mark A. Helvie

Mammographic breast density has been studied for more than 30 years. Greater breast density not only is related to decreased sensitivity of mammograms because of a masking effect but also is a major independent risk factor for breast cancer. This article defines breast density and reviews literature on quantification of mammographic density that is key to future clinical and research protocols. Important influences on breast density are addressed, including age, menopausal status, exogenous hormones, and genetics of density. Young women with dense breasts benefit from digital mammographic technique. The potential use of supplemental MRI and ultrasound screening techniques in high-risk women and women with dense breasts is explored, as are potential risk reduction strategies.


2016 ◽  
Vol 157 (1) ◽  
pp. 179-189 ◽  
Author(s):  
Roberto Agresti ◽  
Elisabetta Meneghini ◽  
Paolo Baili ◽  
Pamela Minicozzi ◽  
Alberto Turco ◽  
...  

2018 ◽  
Vol 12 ◽  
pp. 117822341877197 ◽  
Author(s):  
Afsaneh Alikhassi ◽  
Seyedeh Nooshin Miratashi Yazdi ◽  
Hedieh Akbari ◽  
Sona Akbari Kia ◽  
Masoud Baikpour

Objective: Breast cancer is the most common malignancy in the female population, and imaging studies play a critical role for its early detection. Mammographic breast density (MBD) is one of the markers used to predict the risk stratification of breast cancer in patients. We aimed to assess the correlations among MBD, ultrasound breast composition (USBC), fibroglandular tissue (FGT), and the amount of background parenchymal enhancement (BPE) in magnetic resonance imaging, after considering the subjects’ menopausal status. Methods: In this retrospective cross-sectional study, the medical records’ archives in a tertiary referral hospital were reviewed. Data including age, menopausal status, their mammograms, and ultrasound assessments were extracted from their records. All of their imaging studies were reviewed, and MBD, USBC, FGT, and BPE were determined, recorded, and entered into SPSS software for analysis. Results: A total of 121 women (mean age = 42.7 ± 11.0 years) were included, of which 35 out of 115 (30.4%) had reached menopause. Using the Jonckheere-Terpstra test for evaluating the trends among above mentioned 4 radiologic characteristics in the total sample population, a significant positive relation was found between each of these paired variables: (1) USBC-MBD ( P = .006), (2) FGT-MBD ( P = .001), (3) USBC-BPE ( P = .046), (4) USBC-FGT ( P = .036), and (5) BPE-FGT ( P < .001). These trends were not found to be significant among premenopausal subjects. Conclusions: Considering the trends between different measures of breast density in the 3 radiologic modalities, these factors can be used interchangeably in certain settings.


2016 ◽  
Vol 34 (15_suppl) ◽  
pp. e12067-e12067
Author(s):  
Hitesh Shivalingappa ◽  
Mahvish Muzaffar ◽  
Kathryn Verbanac ◽  
Nasreen A. Vohra

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