Abstract B13: Differential expressions of stress proteins and miRNAs in circulating exosomes in prostate cancer health disparities

2016 ◽  
Author(s):  
Salma Khan ◽  
TessaRae Stiff ◽  
Jennifer Simpson ◽  
James C. Lynch ◽  
Patrick Leaf ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Health Disparities ◽  
Stress Proteins ◽  
Cancer Health Disparities

Psychosocial outcomes in cancer survivors treated at a comprehensive cancer center or a minority-serving institution.

2013 ◽  
Vol 31 (15_suppl) ◽  
pp. e20523-e20523
Author(s):  
Debra L. Friedman ◽  
Maureen Sanderson ◽  
Pamela Hull ◽  
Debra Wujcik ◽  
Dira R Ashworth ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Health Disparities ◽  
Cancer Survivors ◽  
Posttraumatic Growth ◽  
Comprehensive Cancer Center ◽  
Cancer Center ◽  
Cancer Health Disparities ◽  
Mean Values ◽  
Prostate Cancer Survivors ◽  
High School Degree

e20523 Background: Cancer health disparities are well described for incidence, diagnosis and treatment. Little is known about disparities among long-term survivors. Methods: At Vanderbilt-Ingram Cancer Center (VICC), an NCI-designated comprehensive cancer center and Meharry Medical College (MMC), minority serving institutional partner, we evaluated quality of life (QOL) using the FACT-G, FACT-B, FACT-L, and FACT-P; posttraumatic stress disorder (PTSD) using the PTSD Checklist (PCL); and posttraumatic growth (PTG) using the PTG Inventory (PTGI) among breast, lung or prostate cancer survivors. We used linear regression to compare the scale mean values by institution while adjusting for confounding variables. Results: Among 111 breast, 53 lung and 68 prostate cancer survivors, mean age was 62 years, 61% were female, 33% were black, 65% were married, 22% and 67% respectively had a high school degree or some college/higher education, 36% were employed and 94% were insured. MMC survivors were younger (p = 0.0005), more likely to be black (p <0.0001), less likely to be married (p < 0.0001), less educated (p<0.0001) and more likely to be uninsured (p < 0.0001). After adjusting for race, insurance status and educational level, there were no significant differences in cancer-related QOL between VICC and MMC survivors. MMC survivors did score significantly higher than VICC survivors on the PCL (33.9 vs. 28.3; p = 0.01) and the PTGI (75.9 vs. 62.5; p = 0.002). A total of 19 (8.3%) survivors met criteria for PTSD with a score of 50 or more (18.1% MMC, 3.8% VICC, p =0.003). Scores were significantly increased for MMC survivors relative to VICC survivors on all PTG subscales, especially the appreciation for life subscale (p = 0.0005). Conclusions: Cancer health disparities extend into the survivorship period. Although overall QOL did not differ, survivors treated at an underserved institution had significantly higher PTSD than those treated at a comprehensive cancer center. Underserved survivors also exhibited higher degrees of PTG. Further evaluation will identify the most significant sources of stress and resilience in order to design interventions to improve psychosocial wellbeing and decrease disparities.

MP09-13 RACIAL DIFFERENCES IN CIRCULATING MITOCHONDRIA-DERIVED PEPTIDES MAY CONTRIBUTE TO PROSTATE CANCER HEALTH DISPARITIES

2020 ◽  
Vol 203 ◽  
pp. e120-e121
Author(s):  
Adela Ramirez-Torres* ◽  
Allison L. Reagan ◽  
Lauren E. Howard ◽  
Emily Wiggins ◽  
Adriana C. Vidal ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Health Disparities ◽  
Racial Differences ◽  
Cancer Health Disparities

Abstract 5285: Glucocorticoid-mediated upregulation of stress oncoproteins: implications for prostate cancer health disparities

2017 ◽  
Author(s):  
Leanne Woods-Burnham ◽  
Arthur Love ◽  
Christina K. Cajigas-Du Ross ◽  
Laura Stiel ◽  
Evelyn S. Sanchez ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Health Disparities ◽  
Cancer Health Disparities

Abstract 2715: Peroxiredoxin 3: A potential biological determinant of prostate cancer health disparities

2010 ◽  
Author(s):  
Anamika Basu ◽  
Melanie Mediavilla-Varela ◽  
Shannalee Martinez ◽  
Heather Rojas ◽  
Hiya Banergee ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Health Disparities ◽  
Cancer Health Disparities ◽  
Peroxiredoxin 3

Abstract 1118: Stress-induced differential Survivin release in prostate cancer health disparities

2014 ◽  
Author(s):  
Salma Khan ◽  
David Turay ◽  
Jessica Ms Jutzy ◽  
Jonathan R. Aspe ◽  
Tino W. Sanchez ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Health Disparities ◽  
Cancer Health Disparities

scholarly journals The 22Rv1 prostate cancer cell line carries mixed genetic ancestry: Implications for prostate cancer health disparities research using pre-clinical models

The Prostate ◽  
2017 ◽  
Vol 77 (16) ◽  
pp. 1601-1608 ◽  
Author(s):  
Leanne Woods-Burnham ◽  
Anamika Basu ◽  
Christina K. Cajigas-Du Ross ◽  
Arthur Love ◽  
Clayton Yates ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Health Disparities ◽  
Cell Line ◽  
Cancer Cell ◽  
Prostate Cancer Cell ◽  
Cancer Cell Line ◽  
Prostate Cancer Cell Line ◽  
Genetic Ancestry ◽  
Cancer Health Disparities ◽  
Clinical Models
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