scholarly journals Secreted Interleukin-1α Induces a Metastatic Phenotype in Pancreatic Cancer by Sustaining a Constitutive Activation of Nuclear Factor-κB

2009 ◽  
Vol 7 (5) ◽  
pp. 624-633 ◽  
Author(s):  
Davide Melisi ◽  
Jiangong Niu ◽  
Zhe Chang ◽  
Qianghua Xia ◽  
Bailu Peng ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Nuclear Factor Κb ◽  
Nuclear Factor ◽  
Metastatic Phenotype ◽  
Constitutive Activation ◽  
Interleukin 1Α

scholarly journals Macrophages in pancreatic cancer: Starting things off on the wrong track

2013 ◽  
Vol 202 (3) ◽  
pp. 403-405
Author(s):  
Xavier Deschênes-Simard ◽  
Yusuke Mizukami ◽  
Nabeel Bardeesy
Keyword(s):  
Pancreatic Cancer ◽  
Chronic Inflammation ◽  
Acinar Cells ◽  
Nuclear Factor Κb ◽  
Pancreatic Acinar Cells ◽  
Nuclear Factor ◽  
Oncogenic Transformation ◽  
Transcriptional Program ◽  
Cell Biol ◽  
Inflammatory Macrophages

Chronic inflammation drives initiation and progression of many malignancies, including pancreatic cancer. In this issue, Liou et al. (2013. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201301001) report that inflammatory macrophages are major players in the earliest stages of pancreatic cancer. They show that paracrine signals from the macrophages activate the nuclear factor κB transcriptional program in normal pancreatic acinar cells, resulting in acinar–ductal metaplasia, a dedifferentiated state that is poised for oncogenic transformation.

Combination Paclitaxel and Inhibitor of Nuclear Factor κB Activation Improves Therapeutic Outcome for Model Mice With Peritoneal Dissemination of Pancreatic Cancer

Pancreas ◽  
2011 ◽  
Vol 40 (4) ◽  
pp. 600-607 ◽  
Author(s):  
Yuki Fujiwara ◽  
Kenei Furukawa ◽  
Yohta Shimada ◽  
Tomonori Iida ◽  
Hiroaki Shiba ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Peritoneal Dissemination ◽  
Nuclear Factor Κb ◽  
Therapeutic Outcome ◽  
Nuclear Factor

scholarly journals Xanthohumol inhibits angiogenesis by suppressing nuclear factor-κB activation in pancreatic cancer

2017 ◽  
Vol 109 (1) ◽  
pp. 132-140 ◽  
Author(s):  
Kenta Saito ◽  
Yoichi Matsuo ◽  
Hiroyuki Imafuji ◽  
Tomotaka Okubo ◽  
Yuzo Maeda ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Nuclear Factor Κb ◽  
Nuclear Factor

scholarly journals c-Myc–Induced Chemosensitization Is Mediated by Suppression of Cyclin D1 Expression and Nuclear Factor-κB Activity in Pancreatic Cancer Cells

2007 ◽  
Vol 13 (9) ◽  
pp. 2811-2821 ◽  
Author(s):  
Hector Biliran ◽  
Sanjeev Banerjee ◽  
Archana Thakur ◽  
Fazlul H. Sarkar ◽  
Aliccia Bollig ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cyclin D1 ◽  
Cancer Cells ◽  
Nuclear Factor Κb ◽  
Nuclear Factor ◽  
Pancreatic Cancer Cells
Sign in / Sign up

Export Citation Format

Share Document