Polymorphisms in the Vitamin D Receptor Gene and the Androgen Receptor Gene and the Risk of Benign Prostatic Hyperplasia

2000 ◽  
Vol 37 (2) ◽  
pp. 234-238 ◽  
Author(s):  
J. Teun Bousema ◽  
Marion J.G. Bussemakers ◽  
Kjeld P. van Houwelingen ◽  
Frans M.J. Debruyne ◽  
André L.M. Verbeek ◽  
...  
2014 ◽  
Vol 41 (10) ◽  
pp. 6713-6717 ◽  
Author(s):  
Xian-Tao Zeng ◽  
Qi-Sheng Yao ◽  
Hong Weng ◽  
Sheng Li ◽  
Jing-Yu Huang ◽  
...  

2006 ◽  
Vol 118 (12) ◽  
pp. 3140-3146 ◽  
Author(s):  
Martha L. Slattery ◽  
Carol Sweeney ◽  
Maureen Murtaugh ◽  
Khe-Ni Ma ◽  
Bette J. Caan ◽  
...  

1999 ◽  
Vol 162 (1) ◽  
pp. 269-270
Author(s):  
E. Giovannucci ◽  
E.A. Platz ◽  
M.J. Stampfer ◽  
A. Chan ◽  
K. Krithivas ◽  
...  

2015 ◽  
Vol 2015 ◽  
pp. 1-5 ◽  
Author(s):  
Li Ruan ◽  
Jian-guo Zhu ◽  
Cong Pan ◽  
Xing Hua ◽  
Dong-bo Yuan ◽  
...  

Background.The aim of the study was to investigate the association between single nucleotide polymorphism (SNP) of vitamin D receptor (VDR) gene and clinical progress of benign prostatic hyperplasia (BPH) in Chinese men.Methods.The DNA was extracted from blood of 200 BPH patients with operation (progression group) and 200 patients without operation (control group), respectively. The genotypes of VDR gene FokI SNP represented by “F/f” were identified by PCR-restriction fragment length polymorphism. The odds ratio (OR) of having progression of BPH for having the genotype were calculated.Results. Our date indicated that the f alleles of the VDR gene FokI SNP associated with the progression of BPH (P=0.009).Conclusion. For the first time, our study demonstrated that VDR gene FokI SNP may be associated with the risk of BPH progress.


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