scholarly journals Characteristics, Treatment and Outcome of Patients with Non-ST-Elevation Acute Coronary Syndromes and Multivessel Coronary Artery Disease: Observations from PURSUIT (Platelet Glycoprotein IIb/IIIa in Unstable Angina: Receptor Suppression Using Integrelin Therapy)

Cardiology ◽  
2002 ◽  
Vol 98 (4) ◽  
pp. 195-201 ◽  
Author(s):  
Arno Breeman ◽  
Nestor Mercado ◽  
Mattie Lenzen ◽  
Marcel M.J. van den Brand ◽  
Robert A. Harrington ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Unstable Angina ◽  
Acute Coronary Syndromes ◽  
Platelet Glycoprotein ◽  
Multivessel Coronary Artery Disease ◽  
Coronary Syndromes ◽  
St Elevation ◽  
Artery Disease

Epidemiology and pathophysiology of coronary artery disease

2016 ◽  
Author(s):  
Demosthenes G. Katritsis ◽  
Bernard J. Gersh ◽  
A. John Camm
Keyword(s):  
Myocardial Infarction ◽  
Coronary Artery Disease ◽  
Heart Disease ◽  
Coronary Artery ◽  
Unstable Angina ◽  
Acute Coronary Syndromes ◽  
St Elevation Myocardial Infarction ◽  
Coronary Syndromes ◽  
St Elevation ◽  
Artery Disease

This chapter presents the epidemiology and pathophysiology of stable ischaemic heart disease and acute coronary syndromes, i.e. unstable angina/non-ST elevation myocardial infarction and ST elevation myocardial infarction.

Pathophysiology of coronary syndromes

2016 ◽  
Author(s):  
Robert M. Bell
Keyword(s):  
Risk Factors ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Acute Coronary Syndromes ◽  
Vessel Wall ◽  
Inflammatory Process ◽  
Unstable Plaque ◽  
Coronary Syndromes ◽  
St Elevation ◽  
Artery Disease

The pathophysiology of acute coronary syndromes is characterized by an acute mismatch of blood supply to the myocardium to meet the prevailing metabolic need. By far the commonest aetiology of myocardial ischaemia is coronary artery disease . An inflammatory process that evolves over the period of many decades, coronary artery disease is characterized by the deposition of cholesterol and cholesterol laden macrophages within the intima of the vessel wall. This process can be accelerated by a number of cardiovascular risk factors (smoking, hypertension, hyperlipidaemia, hypercholesterolaemia, diabetes), which can culminate in the formation of the unstable plaque responsible for the emergent presentation of ST-elevation myocardial infarction. This chapter reviews the prolonged inflammatory process responsible for atheroma formation, along with rarer, non-atheroma-related causes of acute coronary syndromes.

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