Gene Expression of the Na+–Ca2+ Exchanger, SERCA2a and Calsequestrin after Myocardial Ischemia in the Neonatal Rabbit Heart

Neonatology ◽  
2006 ◽  
Vol 90 (3) ◽  
pp. 174-184 ◽  
Author(s):  
Matthias Seehase ◽  
Thomas Quentin ◽  
Elke Wiludda ◽  
Gerhard Hellige ◽  
Thomas Paul ◽  
...  
Keyword(s):  
Gene Expression ◽  
Myocardial Ischemia ◽  
Rabbit Heart

Angiotensin II Type 1 Receptor Blockade Abolishes Specific KATPChannel Gene Expression in Rats with Myocardial Ischemia

2000 ◽  
Vol 32 (12) ◽  
pp. 2239-2247 ◽  
Author(s):  
Masaharu Akao ◽  
Takahiro Sakurai ◽  
Minoru Horie ◽  
Hideo Otani ◽  
Makoto Takano ◽  
...  
Keyword(s):  
Gene Expression ◽  
Angiotensin Ii ◽  
Myocardial Ischemia ◽  
Receptor Blockade

scholarly journals Multitarget Effects of Danqi Pill on Global Gene Expression Changes in Myocardial Ischemia

2018 ◽  
Vol 2018 ◽  
pp. 1-11 ◽  
Author(s):  
Qiyan Wang ◽  
Hui Meng ◽  
Qian Zhang ◽  
Tianjiao Shi ◽  
Xuefeng Zhang ◽  
...  
Keyword(s):  
Gene Expression ◽  
Myocardial Ischemia ◽  
Differentially Expressed Genes ◽  
Sham Group ◽  
Gene Expression Pattern ◽  
Enrichment Analysis ◽  
Global Gene Expression ◽  
Differentially Expressed ◽  
Group Model ◽  
Model Group

Danqi pill (DQP) is a widely prescribed traditional Chinese medicine (TCM) in the treatment of cardiovascular diseases. The objective of this study is to systematically characterize altered gene expression pattern induced by myocardial ischemia (MI) in a rat model and to investigate the effects of DQP on global gene expression. Global mRNA expression was measured. Differentially expressed genes among the sham group, model group, and DQP group were analyzed. The gene ontology enrichment analysis and pathway analysis of differentially expressed genes were carried out. We quantified 10,813 genes. Compared with the sham group, expressions of 339 genes were upregulated and 177 genes were downregulated in the model group. The upregulated genes were enriched in extracellular matrix organization, response to wounding, and defense response pathways. Downregulated genes were enriched in fatty acid metabolism, pyruvate metabolism, PPAR signaling pathways, and so forth. This indicated that energy metabolic disorders occurred in rats with MI. In the DQP group, expressions of genes in the altered pathways were regulated back towards normal levels. DQP reversed expression of 313 of the 516 differentially expressed genes in the model group. This study provides insight into the multitarget mechanism of TCM in the treatment of complex diseases.

Reduction of acute myocardial ischemia in isolated rabbit heart by hyaluronidase

1980 ◽  
Vol 45 (2) ◽  
pp. 485 ◽  
Author(s):  
Michael B. Simson ◽  
Wesley R. Harden ◽  
Clyde H. Barlow ◽  
Bruce Slagle ◽  
Alden H. Harken
Keyword(s):  
Myocardial Ischemia ◽  
Rabbit Heart ◽  
Acute Myocardial Ischemia ◽  
Isolated Rabbit Heart

scholarly journals Analysis of region specific gene expression patterns in the heart and systemic responses after experimental myocardial ischemia

Oncotarget ◽  
2017 ◽  
Vol 8 (37) ◽  
pp. 60809-60825
Author(s):  
Matthias Zimmermann ◽  
Lucian Beer ◽  
Robert Ullrich ◽  
Dominika Lukovic ◽  
Elisabeth Simader ◽  
...  
Keyword(s):  
Gene Expression ◽  
Myocardial Ischemia ◽  
Expression Patterns ◽  
Gene Expression Patterns ◽  
Specific Gene ◽  
Specific Gene Expression ◽  
Experimental Myocardial Ischemia ◽  
Systemic Responses

scholarly journals Myocardial ischemia induces differential regulation of KATP channel gene expression in rat hearts.

1997 ◽  
Vol 100 (12) ◽  
pp. 3053-3059 ◽  
Author(s):  
M Akao ◽  
H Otani ◽  
M Horie ◽  
M Takano ◽  
A Kuniyasu ◽  
...  
Keyword(s):  
Gene Expression ◽  
Myocardial Ischemia ◽  
Katp Channel ◽  
Differential Regulation ◽  
Channel Gene ◽  
Rat Hearts

scholarly journals Complement Gene Expression is Upregulated in the Type 2 Diabetic Heart Following Myocardial Ischemia and Reperfusion

2007 ◽  
Vol 21 (6) ◽  
Author(s):  
Corrine E Walker ◽  
Garrett S Pacheco ◽  
Laura R La Bonte ◽  
Grace Davis‐Gorman ◽  
Gregory L Stahl ◽  
...  
Keyword(s):  
Gene Expression ◽  
Myocardial Ischemia ◽  
Diabetic Heart ◽  
Ischemia And Reperfusion ◽  
Myocardial Ischemia And Reperfusion ◽  
Complement Gene ◽  
Type 2 Diabetic
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