Improvement of Episodic Memory in Persons with Mild Cognitive Impairment and Healthy Older Adults: Evidence from a Cognitive Intervention Program

ABSTRACT Background: To date, there is a controversy on effects of cognitive intervention to maintain or improve hippocampal function for older adults with mild cognitive impairment (MCI). Objective: The main objective of this study was to exam effects of virtual reality-based spatial cognitive training (VR-SCT) using VR on hippocampal function of older adults with MCI. Method: Fifty-six older adults with MCI were randomly allocated to the experimental group (EG) that received the VR-SCT or the waitlist control group (CG) for a total of 24 sessions. To investigate effects of the VR-SCT on spatial cognition and episodic memory, the Weschsler Adult Intelligence Scale-Revised Block Design Test (WAIS-BDT) and the Seoul Verbal Learning Test (SVLT) were used. Results: During the sessions, the training performances gradually increased (p < .001). After the intervention, the EG showed significant greater improvements in the WAIS-BDT (p < .001, η2 = .667) and recall of the SVLT (p < .05, η2 =.094) compared to the CG but in recognition of the SVLT (p > .05, η2 =.001). Conclusion: These results suggest that the VR-SCT might be clinically beneficial to enhance spatial cognition and episodic memory of older adults with MCI.

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P1-301: fMRI activation changes during successful episodic memory encoding and recognition in amnestic mild cognitive impairment relative to cognitively healthy older adults

Alzheimer s & Dementia ◽

10.1016/j.jalz.2008.05.892 ◽

2008 ◽

Vol 4 ◽

pp. T307-T307

Author(s):

Mehul A. Trivedi ◽

Christopher M. Murphy ◽

Celine Goetz ◽

Raj C. Shah ◽

John D.E. Gabrieli ◽

...

Keyword(s):

Older Adults ◽

Cognitive Impairment ◽

Mild Cognitive Impairment ◽

Episodic Memory ◽

Amnestic Mild Cognitive Impairment ◽

Memory Encoding ◽

Healthy Older Adults

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Association between tea consumption and cognitive function in cognitively healthy older adults and older adults with mild cognitive impairment

General Psychiatry ◽

10.1136/gpsych-2021-100512 ◽

2021 ◽

Vol 34 (4) ◽

pp. e100512

Author(s):

Hua Xu ◽

Alexandra J Fiocco ◽

Xiaohua Liu ◽

Tao Wang ◽

Guanjun Li ◽

...

Keyword(s):

Older Adults ◽

Working Memory ◽

Cognitive Impairment ◽

Mild Cognitive Impairment ◽

Cognitive Function ◽

Episodic Memory ◽

Cognitive Performance ◽

Tea Consumption ◽

Healthy Older Adults ◽

Global Cognitive Function

BackgroundProspective studies suggest that tea consumption may decrease the risk for cognitive impairment in late life. However, little research has examined the association between tea consumption and cognitive performance across multiple domains. In addition, no research has examined the benefit of tea consumption on cognitive performance among older adults with existing impairment.AimsThe current study examined the association between tea consumption and performance on tasks of global cognitive function, episodic memory and executive function in cognitively healthy (CH) older adults and older adults with mild cognitive impairment (MCI).MethodsThe analytical sample included 1849 community-dwelling older adults from the Shanghai Brain Aging Study (65.6% female, mean age of 69.50 (8.02) years). Following ascertainment of cognitive function, 816 were categorised as MCI. In addition to completion of a demographics questionnaire, participants reported their tea consumption and completed a battery of tests to measure global cognitive function, episodic memory and working memory.ResultsIndependent analyses of covariance revealed a significant association between tea consumption and measures of episodic memory; however, these associations were restricted to CH older adults but not older adults with MCI. Tea consumption was not associated with working memory performance.ConclusionsThe current study suggests that the benefit of tea consumption is restricted to cognitively healthy older adults and does not extend to older adults with MCI.

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Test-retest reliability of fMRI verbal episodic memory paradigms in healthy older adults and in persons with mild cognitive impairment

Human Brain Mapping ◽

10.1002/hbm.20827 ◽

2009 ◽

Vol 30 (12) ◽

pp. 4033-4047 ◽

Cited By ~ 41

Author(s):

Francis Clément ◽

Sylvie Belleville

Keyword(s):

Older Adults ◽

Cognitive Impairment ◽

Mild Cognitive Impairment ◽

Episodic Memory ◽

Retest Reliability ◽

Healthy Older Adults ◽

Test Retest Reliability ◽

Verbal Episodic Memory

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IC-P1-062: fMRI activation changes during successful episodic memory encoding and recognition in amnestic mild cognitive impairment relative to cognitively healthy older adults

Alzheimer s & Dementia ◽

10.1016/j.jalz.2008.05.2504 ◽

2008 ◽

Vol 4 ◽

pp. T33-T33

Author(s):

Mehul A. Trivedi ◽

Christopher M. Murphy ◽

Celine Goetz ◽

Raj C. Shah ◽

John D.E. Gabrieli ◽

...

Keyword(s):

Older Adults ◽

Cognitive Impairment ◽

Mild Cognitive Impairment ◽

Episodic Memory ◽

Amnestic Mild Cognitive Impairment ◽

Memory Encoding ◽

Healthy Older Adults

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Multi-Component Intervention Program on Habitual Physical Activity Parameters and Cognitive Function in Patients with Mild Cognitive Impairment: A Randomized Controlled Trial

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph18126240 ◽

2021 ◽

Vol 18 (12) ◽

pp. 6240

Author(s):

Min-Ki Jeong ◽

Kyung-Won Park ◽

Je-Kwang Ryu ◽

Gwon-Min Kim ◽

Hyun-Hun Jung ◽

...

Keyword(s):

Physical Activity ◽

Cognitive Impairment ◽

Mild Cognitive Impairment ◽

Cognitive Function ◽

Intervention Program ◽

Vigorous Physical Activity ◽

Cognitive Intervention ◽

Habitual Physical Activity ◽

Disease Assessment ◽

Digit Symbol Substitution Test

Age-related dementia refers to a state in which someone experiences multiple cognitive function impairment due to degenerative brain disease, and which causes difficulties in their daily life or social life. Dementia is the most common and serious obstacle in later life. Early intervention in the case of patients who are in the mild cognitive impairment (MCI) stage among the high-risk group can maintain and improve their cognitive function. The purpose of the current trial is aimed at investigating the association between a multi-component (exercise with cognitive) intervention program and habitual physical activity parameters on cognitive functions in MCI patients. Neuropsychological cognitive and depression assessments were performed by neuropsychologists according to normalized methods, including the Korean mini-mental State examination (K-MMSE) and modified Alzheimer’s disease assessment scale-cognitive subscale (ADAS-Cog) and cognitive assessment tool (attention, processing speed), and the Korean version of the geriatric depression scale (SGDS-K), both at baseline and at a 12 weeks follow-up. The 12-week multi-component intervention improved cognitive function and habitual physical activity parameters in patients with MCI relative to controls. A multi-component intervention program for patients with MCI is considered to be an effective method of dementia prevention by improving global (ADAS-Cog) and frontal (trail-making test, digit symbol substitution test) cognition and habitual physical activity parameters such as moderate to vigorous physical activity and step count. In addition, it is important to encourage habitual physical activities to ensure that exercise intervention strategies are carried out at the duration and intensity required for improving physical and cognitive wellbeing and obtaining health benefits.

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Repetition Priming in Individuals with Amnestic Mild Cognitive Impairment and Alzheimer’s Dementia: a Systematic Review and Meta-Analysis

Neuropsychology Review ◽

10.1007/s11065-021-09504-5 ◽

2021 ◽

Author(s):

Liselotte De Wit ◽

Vitoria Piai ◽

Pilar Thangwaritorn ◽

Brynn Johnson ◽

Deirdre O’Shea ◽

...

Keyword(s):

Systematic Review ◽

Older Adults ◽

Cognitive Impairment ◽

Mild Cognitive Impairment ◽

Repetition Priming ◽

Meta Analysis ◽

Healthy Older Adults ◽

Amnestic Mci ◽

Standard Mean Difference ◽

Priming Paradigm

AbstractThe literature on repetition priming in Alzheimer’s disease (AD) is inconsistent, with some findings supporting spared priming while others do not. Several factors may explain these inconsistencies, including AD severity (e.g., dementia vs. Mild Cognitive Impairment; MCI) and priming paradigm-related characteristics. This systematic review and meta-analysis provides a quantitative summary of repetition priming in AD. We examined the between-group standard mean difference comparing repetition priming in AD dementia or amnestic MCI (aMCI; presumably due to AD) to controls. Thirty-two studies were selected, including 590 individuals with AD dementia, 267 individuals with amnestic MCI, and 703 controls. Our results indicated that both individuals with aMCI and AD dementia perform worse on repetition priming tasks than cognitively older adults. Paradigm-related moderators suggested that the effect size between studies comparing the combined aMCI or AD dementia group to cognitively healthy older adults was the highest for paradigms that required participants to produce, rather than identify, primes during the test phase. Our results further suggested that priming in AD is impaired for both conceptual and perceptual priming tasks. Lastly, while our results suggested that priming in AD is impaired for priming tasks that require deep processing, we were unable to draw firm conclusions about whether priming is less impaired in aMCI or AD dementia for paradigms that require shallow processing.

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Five-Year Change in Body Mass Index Predicts Conversion to Mild Cognitive Impairment or Dementia Only in APOE ɛ4 Allele Carriers

Journal of Alzheimer s Disease ◽

10.3233/jad-201360 ◽

2021 ◽

pp. 1-11

Author(s):

Kylie R. Kadey ◽

John L. Woodard ◽

Allison C. Moll ◽

Kristy A. Nielson ◽

J. Carson Smith ◽

...

Keyword(s):

Older Adults ◽

Body Mass Index ◽

Cognitive Impairment ◽

Mild Cognitive Impairment ◽

Body Mass ◽

Carrier Status ◽

Healthy Older Adults ◽

E4 Allele ◽

Lifestyle Risk

Background: Body mass index (BMI) has been identified as an important modifiable lifestyle risk factor for dementia, but less is known about how BMI might interact with Apolipoprotein E ɛ4 (APOE ɛ4) carrier status to predict conversion to mild cognitive impairment (MCI) and dementia. Objective: The aim of this study was to investigate the interaction between APOE ɛ4 status and baseline (bBMI) and five-year BMI change (ΔBMI) on conversion to MCI or dementia in initially cognitively healthy older adults. Methods: The associations between bBMI, ΔBMI, APOE ɛ4 status, and conversion to MCI or dementia were investigated among 1,289 cognitively healthy elders from the National Alzheimer’s Coordinating Center (NACC) database. Results: After five years, significantly more carriers (30.6%) converted to MCI or dementia than noncarriers (17.6%), p < 0.001, OR = 2.06. Neither bBMI (OR = 0.99, 95%CI = 0.96–1.02) nor the bBMI by APOE interaction (OR = 1.02, 95%CI = 0.96–1.08) predicted conversion. Although ΔBMI also did not significantly predict conversion (OR = 0.90, 95%CI = 0.78–1.04), the interaction between ΔBMI and carrier status was significant (OR = 0.72, 95%CI = 0.53–0.98). For carriers only, each one-unit decline in BMI over five years was associated with a 27%increase in the odds of conversion (OR = 0.73, 95%CI = 0.57–0.94). Conclusion: A decline in BMI over five years, but not bBMI, was strongly associated with conversion to MCI or dementia only for APOE ɛ4 carriers. Interventions and behaviors aimed at maintaining body mass may be important for long term cognitive health in older adults at genetic risk for AD.

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