Altered Expression of Lymphocyte Homing Chemokines in the Pathogenesis of IgA Nephropathy

2007 ◽  
pp. 50-55 ◽  
Author(s):  
Marc Buren ◽  
Michifumi Yamashita ◽  
Yusuke Suzuki ◽  
Yasuhiko Tomino ◽  
Steven N. Emancipator
Keyword(s):  
Iga Nephropathy ◽  
Lymphocyte Homing ◽  
Altered Expression

scholarly journals Altered expression of fibrogenic growth factors in IgA nephropathy and focal and segmental glomerulosclerosis

1997 ◽  
Vol 51 (1) ◽  
pp. 195-204 ◽  
Author(s):  
Alicia N. Stein-Oakley ◽  
Julie A. Maguire ◽  
John Dowling ◽  
Greg Perry ◽  
Napier M. Thomson
Keyword(s):  
Growth Factors ◽  
Iga Nephropathy ◽  
Focal And Segmental Glomerulosclerosis ◽  
Altered Expression ◽  
Segmental Glomerulosclerosis

Implication of Peritubular Capillary Loss and Altered Expression of Vascular Endothelial Growth Factor in IgA Nephropathy

2006 ◽  
Vol 102 (1) ◽  
pp. p9-p16 ◽  
Author(s):  
Tamehachi Namikoshi ◽  
Minoru Satoh ◽  
Hideyuki Horike ◽  
Sohachi Fujimoto ◽  
Sayaka Arakawa ◽  
...  
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Iga Nephropathy ◽  
Vascular Endothelial ◽  
Peritubular Capillary ◽  
Altered Expression ◽  
Endothelial Growth Factor

scholarly journals Stress regulates the lymphocyte homing receptor CD62L (L-selectin)

2003 ◽  
Vol 61 (1) ◽  
pp. 20-24 ◽  
Author(s):  
Gisele Gus Manfro ◽  
Carlos Alexandre Netto ◽  
Mark Pollack ◽  
Kelin Maggioni Mezzomo ◽  
Frederic Preffer ◽  
...  
Keyword(s):  
Panic Disorder ◽  
Mononuclear Cells ◽  
Ex Vivo ◽  
Interleukin 2 ◽  
Lymphocyte Homing ◽  
Altered Expression ◽  
Surface Molecules ◽  
Ex Vivo Study ◽  
Previous Clinical Study

Based on a previous study showing that panic disorder patients had increased expression of naïve phenotype lymphocytes (CD45RA+ and CD62L+), increased plasma cortisol, as well as decreased interleukin-2 (IL-2) producion, we hypothesized that changes in the percentage of expression of these lymphocyte surface molecules could be related to the substances released by the hypothalamic-pituitary-adrenal (HPA) axis and possibly associated to panic disorder (cortisol, IL-2, serotonin and epinephrine). In order to study the altered expression, blood mononuclear cells of normal volunteers were stimulated with mitogen, in the presence of dexamethasone, IL-2, serotonin and epinephrin. CD62L is decreased by IL-2 in vitro. Serotonin and epinephrine did not promote changes in the expression of these surface molecules. The results of the ex vivo study are in agreement with a previous clinical study with panic patients. It could be suggested that stress is responsible for certain immunologic dysfunctions and new studies should be conducted.

Interstitial inflammation and the expression of apoptotic modulators in iga nephropathy

Nephrology ◽  
2000 ◽  
Vol 5 (3) ◽  
pp. A114-A114
Author(s):  
Menahem Sa ◽  
Maguire Ja ◽  
Stein‐Oakley A ◽  
Bailey M ◽  
Dowling J ◽  
...  
Keyword(s):  
Iga Nephropathy ◽  
Interstitial Inflammation

Alteration of intestinal epithelial functions by intraepithelial lymphocyte homing

2001 ◽  
Vol 120 (5) ◽  
pp. A191-A191
Author(s):  
T SHIBAHARA ◽  
A YANAKA ◽  
H SUZUKI ◽  
J MADARA
Keyword(s):  
Intraepithelial Lymphocyte ◽  
Intestinal Epithelial ◽  
Lymphocyte Homing

The Oral Intake of Organic Germanium, Ge-132, Elevates α-Tocopherol Levels in the Plas-ma and Modulates Hepatic Gene Expression Profiles to Promote Immune Activation in Mice

2014 ◽  
Vol 84 (3-4) ◽  
pp. 0183-0195 ◽  
Author(s):  
Takashi Nakamura ◽  
Tomoya Takeda ◽  
Yoshihiko Tokuji
Keyword(s):  
Gene Expression ◽  
Immune Activation ◽  
Expression Profiles ◽  
Water Soluble ◽  
Alpha Tocopherol ◽  
Hepatic Gene Expression ◽  
Tocopherol Concentration ◽  
Altered Expression ◽  
Atp Production ◽  
Transfer Protein

The common water-soluble organic germanium compound poly-trans-[(2-carboxyethyl) germasesquioxane] (Ge-132) exhibits activities related to immune responses and antioxidant induction. In this study, we evaluated the antioxidative effect of dietary Ge-132 in the plasma of mice. Male ICR mice (seven mice per group) received an AIN-76 diet with 0.05 % Ge-132; three groups received the Ge-132-containing diet for 0, 1 or 4 days. The plasma alpha-tocopherol (α-tocopherol) concentration increased from 6.85 to 9.60 μg/ml after 4 days of Ge-132 intake (p < 0.05). We evaluated the changes in hepatic gene expression related to antioxidative activity as well as in the entire expression profile after one day of Ge-132 intake, using DNA microarray technology. We identified 1,220 genes with altered expression levels greater than 1.5-fold (increased or decreased) as a result of Ge-132 intake, and α-tocopherol transfer protein (Ttpa) gene expression was increased 1.62-fold. Immune activation was identified as the category with the most changes (containing 60 Gene Ontology (GO) term biological processes (BPs), 41 genes) via functional clustering analysis of altered gene expression. Ge-132 affected genes in clusters related to ATP production (22 GO term BPs, 21 genes), lipid metabolism (4 GO term BPs, 38 genes) and apoptosis (5 GO term BPs). Many GO term BPs containing these categories were significantly affected by the Ge-132 intake. Oral Ge-132 intake may therefore have increased plasma α-tocopherol levels by up-regulating α-tocopherol transfer protein (Ttpa) gene expression.

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