Diurnal Variation in Neuroendocrine Response to Stress in Rats: Plasma ACTH, β-Endorphin, β-LPH, Corticosterone, Prolactin and Pituitary Cyclic AMP Responses

1986 ◽  
Vol 43 (3) ◽  
pp. 383-390 ◽  
Author(s):  
Jean Kant ◽  
Edward H. Mougey ◽  
James L. Meyerhoff
Keyword(s):  
Cyclic Amp ◽  
Diurnal Variation ◽  
Plasma Acth ◽  
Neuroendocrine Response ◽  
Response To Stress

scholarly journals Pharmacological augmentation of endocannabinoid signaling reduces the neuroendocrine response to stress

2018 ◽  
Vol 87 ◽  
pp. 131-140 ◽  
Author(s):  
Pablo Nicolás Surkin ◽  
Sofia Ludmila Gallino ◽  
Valeria Luce ◽  
Fernando Correa ◽  
Javier Fernandez-Solari ◽  
...  
Keyword(s):  
Neuroendocrine Response ◽  
Response To Stress

Reduction of Adrenocortiocotropic Hormone (ACTH) and Cortisol in Drug Addicts Treated by Acupuncture and Electrical Stimulation (AES)

1978 ◽  
Vol 06 (01) ◽  
pp. 61-66 ◽  
Author(s):  
H. L. WEN ◽  
W. K. K. HO ◽  
H. K. WONG ◽  
Z. D. MEHAL ◽  
Y. H. NG ◽  
...  
Keyword(s):  
Electrical Stimulation ◽  
Cyclic Amp ◽  
Drug Addicts ◽  
Plasma Acth ◽  
Heroin Addicts ◽  
Cortisol Levels ◽  
The Brain

Forty-two heroin addicts and 31 normal persons were examined for the effect of acupuncture and electrical stimulation (AES) on plasma ACTH, cortisol and cyclic-AMP levels. Both ACTH and cortisol levels were reduced significantly in the addicts after treatment whereas no such significant reduction was observed in the normals. Plasma cyclic-AMP level was not affected in either group. Taken together, results from the present study suggest that the mechanism of AES in the treatment of addiction may have a neuroendocrinological basis. This hypothesis is particularly attractive in view of the isolation of opiate-like peptides from the brain.

Comparison of the effects of CRF and stress on levels of pituitary cyclic AMP and plasma ACTH in vivo

Peptides ◽  
1986 ◽  
Vol 7 (6) ◽  
pp. 1153-1158 ◽  
Author(s):  
G.Jean Kant ◽  
Marvin A. Oleshansky ◽  
Donna D. Walczak ◽  
Edward H. Mougey ◽  
James L. Meyerhoff
Keyword(s):  
Cyclic Amp ◽  
Plasma Acth

The neuroendocrine response to stress under the effect of drugs: Negative synergy between amphetamine and stressors

2016 ◽  
Vol 63 ◽  
pp. 94-101 ◽  
Author(s):  
Almudena Gómez-Román ◽  
Juan A. Ortega-Sánchez ◽  
David Rotllant ◽  
Humberto Gagliano ◽  
Xavier Belda ◽  
...  
Keyword(s):  
Neuroendocrine Response ◽  
Response To Stress

Subsensitive pituitary cyclic AMP response to stress following adrenalectomy is not caused by loss of adrenal epinephrine

Life Sciences ◽  
1985 ◽  
Vol 36 (25) ◽  
pp. 2421-2428 ◽  
Author(s):  
G. Jean Kant ◽  
Carl J. Nielsen ◽  
Marvin A. Oleshansky ◽  
Edward H. Mougey ◽  
Lee L. Pennington ◽  
...  
Keyword(s):  
Cyclic Amp ◽  
Response To Stress

INHIBITION BY DEXAMETHASONE OF ADRENOCORTICOTROPHIN AND CORTISOL RELEASE INDUCED BY INTRAVENOUS INFUSION OF ATP AND DIBUTYRYL CYCLIC AMP IN PIGLETS

1974 ◽  
Vol 60 (1) ◽  
pp. 65-73 ◽  
Author(s):  
D. B. COOK ◽  
G. V. GILL ◽  
I. M. D. JACKSON ◽  
G. A. SMART
Keyword(s):  
Cyclic Amp ◽  
Intravenous Infusion ◽  
Similar Pattern ◽  
Plasma Cortisol ◽  
Dibutyryl Cyclic Amp ◽  
Plasma Acth ◽  
Intravenous Infusions ◽  
Consistent Increase ◽  
Cortisol Release ◽  
Corticosteroid Response

SUMMARY The effect of intravenous infusions of ATP and dibutyryl cyclic AMP (DB cyclic AMP) on adrenocorticotrophin (ACTH) and corticosteroid release was investigated in piglets. A consistent increase of both plasma ACTH and plasma cortisol was observed in response to infusions of 600 mg ATP/h. These responses were abolished by pretreating the animals with dexamethasone. A similar pattern of response was observed with DB cyclic AMP infused intravenously. No response occurred when 100 mg DB cyclic AMP were infused in 1 h, but there was a marked plasma corticosteroid response to an infusion of 600 mg DB cyclic AMP in 1 h. Surprisingly, this response was also abolished by pretreatment with dexamethasone.

EVALUATION OF A RADIOIMMUNOASSAY FOR PLASMA ADRENOCORTICOTROPHIN

1978 ◽  
Vol 78 (3) ◽  
pp. 309-319 ◽  
Author(s):  
J. MARTON ◽  
E. STARK ◽  
KATALIN MERÉTEY ◽  
D. SCHULSTER
Keyword(s):  
Rabbit Antiserum ◽  
Rat Plasma ◽  
Cross Reactivity ◽  
Activity Measurement ◽  
Plasma Acth ◽  
Rat Pituitary ◽  
Close Relationship ◽  
Response To Stress ◽  
Preliminary Extraction ◽  
Plasma Extraction

A radioimmunoassay for plasma ACTH has been described and evaluated. Rabbit antiserum produced by immunization with Asp25, Ala26, Gly27,]-αh-corticotrophin-(1–28)-octacosa-peptide (a sequence analogue of αh1-28-ACTH) bovine gamma globulin conjugate was used. The antiserum is specific for the NH2-terminal portion of the ACTH molecule and cross-reactivity of human, porcine and rat ACTH in the system has been demonstrated. Reasonable agreement was found between estimates obtained by bioassay and radioimmunoassay of the ACTH content of rat pituitary gland incubation media, indicating a close relationship between the sequence of ACTH recognized by the antibodies and the sequence possessing the steroidogenic activity. Measurement of the amount of ACTH in the plasma required the preliminary extraction and concentration of the hormone. Over a range of concentrations between 3·5 and 3600 pg/ml, extraction recovery was independent of the initial concentration of ACTH in the plasma. Extraction gave rise to no changes in the immunological properties of standard ACTH. The concentration of immunoreactive ACTH in rat plasma was 48 ± 3·6 (s.e.m.) pg/ml in the morning and 106 ± 9·9 pg/ml in the afternoon. Exposure to ether for 5 min and subsequent laparotomy gave rise to a significant increase in the concentration of immunoreactive ACTH in the plasma. The resting level of ACTH and the ACTH response to stress were both significantly higher 1 and 7 days after adrenalectomy. Intravenous injection of a hypothalamic extract elicited a considerable rise in the concentration of immunoreactive ACTH in the plasma, but no response was seen after oral administration of this partially purified extract. The sensitivity, precision and specificity of this ACTH radioimmunoassay make it a useful tool for studying pituitary– adrenal physiology.

Chemical stimulation of the dorsomedial hypothalamus elevates plasma ACTH in conscious rats

2001 ◽  
Vol 280 (1) ◽  
pp. R8-R15 ◽  
Author(s):  
Timothy W. Bailey ◽  
Joseph A. Dimicco
Keyword(s):  
Locomotor Activity ◽  
Cardiovascular Response ◽  
Chemical Stimulation ◽  
Experimental Stress ◽  
Plasma Acth ◽  
Similar Treatment ◽  
Dorsomedial Hypothalamus ◽  
Conscious Rats ◽  
Response To Stress ◽  
Stimulation Of

The hallmark neuroendocrine response to stress is increased plasma ACTH. Inhibition of neurons in the region of the dorsomedial hypothalamus (DMH) attenuates experimental air stress-induced elevation of heart rate (HR), mean arterial pressure (MAP), and plasma ACTH. We hypothesized that, under basal conditions, stimulation of the DMH would mimic the neuroendocrine and cardiovascular response to air stress. We examined the effects of unilateral microinjection (100-nl vol) of bicuculline methiodide (BMI, 10 pmol), kainate (KA, 1 or 3 pmol), and N-methyl-d-aspartate (5 pmol) into the DMH or the paraventicular nucleus (PVN) on HR, MAP, locomotor activity, and plasma ACTH in conscious rats. Chemical stimulation of the DMH with KA or BMI produced increased locomotor activity and effects on HR, MAP, and plasma ACTH that together mimicked the pattern seen in experimental stress. Similar treatment in the PVN produced only small increases in MAP. Thus activation of neurons in the region of the DMH results in increased secretion of ACTH along with other changes typically seen in experimental stress.

Sign in / Sign up

Export Citation Format

Share Document